Abstract
Comparison of astroglial immunoreactivity in mesencephalon, cerebellum, and hippocampus of 25-d-old rat pups exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through the mother's milk was made using a quantitative immunohistochemical analysis. A glial reaction was detected at the level of serotonergic nuclei and extreme astrogliosis in the hippocampus and cerebellum. A quantitative analysis of reactive astrocytes was performed by using GFAP and S-100 protein as specific markers. The study showed a significant increase in their number, size, number of processes, and density of immunostaining in 2,4-D-exposed animals.
Exposure to 2,4-dichlorophenoxyacetic acid on the first days of life modifies the astroglial cytoarchitecture in parallel to previously described neuronal changes.
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Brusco, A., Saavedra, J.P., García, G. et al. 2,4-dichlorophenoxyacetic acid through lactation induces astrogliosis in rat brain. Molecular and Chemical Neuropathology 30, 175–185 (1997). https://doi.org/10.1007/BF02815096
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DOI: https://doi.org/10.1007/BF02815096