Abstract
The antifungal effect of 2-alkylthio-6-amino-and 2-alkylthio-6-formamidobenzothiazoles (22 derivatives in all) onAspergillus niger and variousCandida yeasts was tested. No significant effect was observed withA. niger. With the pathogenic yeast speciesC. albicans andC. guilliermondii, the most efficient derivatives (6-formamido-2-propylthio-, 6-formamido-2-butylthio-, 6-formamido-2-pentylthio-and 6-formamido-2-isopentylthiobenzothiazole) exhibited ED50 values in the range from 2.2 to 21 mg/L and were thus 3–35 times more efficient than 2-mercaptobenzothiazole (Dermacid) that is normally used. 6-Amino-2-pentylthiobenzothiazole was found to be an efficient specific inhibitor of the transformation of the yeast form ofC. albicans to its mycelial one, IC95(M) being 10 mg/L, which was a concentration 25 times lower than MICY+M.
Similar content being viewed by others
References
Drobnica L’.: Adaptation of yeast and bacteria to antimicrobial substances during continuous flow cultivation.Folia Microbiol. 5, 257–263 (1960).
Kuchta T., Bujdáková H., Sidóová E., Neslušanová E.: Antimicrobial effect of benzothiazole derivatives VII. 2-Alkylthio-6-aminobenzothiazoles—antifungal activityin vitro and inhibition of yeast-mycelial conversion.Acta Fac. Rer. Natur. Univ. Comen. (Microbiologia) 17, in press (1989).
Marichal P., Gorrens J., Van Cutsem J., Vanden Bossche H.: Culture media for the study of the effects of azole derivatives on germ tube formation and hyphal growth ofC. albicans.Mykosen 29, 76–81 (1986).
Plempel M., Berg D., Büchel K.-H., Abbink D.: Test methods for antifungal agents—a critical review.Mykosen 30, 28–37 (1987).
Schaude M., Ackerbauer H., Mieth H.: Inhibitory effect of antifungal agents on germ tube formation inCandida albicans.Mykosen 30, 281–287 (1987).
Sidóová E., Odlerová Ž., Volná F., Blöckinger G.: Synthesis and antimicrobial activity of 2-alkylthio-6-aminobenzothiazoles.Chem. Papers 33, 830–836 (1979).
Sidóová E., Odlerová Ž.: 2-Alkylthio-6-formamidobenzothiazoles.Czechosl. Pat. 257 398 (1987).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kuchta, T., Bujdáková, H. & Sidóová, E. Inhibition of yeast-mycelium transformation by 2-alkylthio-6-amino-and 2-alkylthio-6-formamidobenzothiazoles and theirin vitro antifungal activity. Folia Microbiol 34, 504–510 (1989). https://doi.org/10.1007/BF02814461
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02814461