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The effect of IL-6 on the des-gamma-carboxy prothrombin synthesis in human hepatoma cells

  • Liver, Pancreas and Biliary Tract
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

Effects of several cytokines on des-gamma-carboxy prothrombin (PIVKA II) synthesis in human hepatoma cells were investigated to know the process of PIVKA II production during a liver allograft rejection. Human recombinant interleukin-6 (IL-6) significantly stimulated the PIVKA II synthesis without any influence on the cell proliferation. The effect was almost completely neutralized by the specific anti-IL-6 antibody. Neither tumor necrosis factor (TNF), interleukin-1 (IL-1) nor interferon-gamma (IFN-gamma) had such a stimulative effect. IL-6 appears to stimulate PIVKA II production, and would be a candidate of factors that enhance the production of PIVKA II during a liver allograft rejection.

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Abbreviations

PFVKA II:

des-gamma-carboxy prothrombin

TNF:

tumor necrosis factor

IL-1:

interleukin-1

IL-6:

interleukin-6

IFN-gamma:

interferon-gamma

ELISA:

enzyme-linked immunosorbent assay

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Authors and Affiliations

  1. Third Departments of Internal Medicine, Asahikawa Medical College, 4-5 Nishikagura, Asahikawa, 078, Hokkaido, Japan

    Minoru Ono, Hironobu Kohda, Tooru Naraki, Hitoyoshi Ohta, Motoyuki Ohhira M.D., Chihiro Sekiya & Masayoshi Namiki

Authors
  1. Minoru Ono
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  2. Hironobu Kohda
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  3. Tooru Naraki
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  4. Hitoyoshi Ohta
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  5. Motoyuki Ohhira M.D.
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  6. Chihiro Sekiya
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  7. Masayoshi Namiki
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Ono, M., Kohda, H., Naraki, T. et al. The effect of IL-6 on the des-gamma-carboxy prothrombin synthesis in human hepatoma cells. Gastroenterol Jpn 27, 745–750 (1992). https://doi.org/10.1007/BF02806527

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  • DOI: https://doi.org/10.1007/BF02806527

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