Summary
Although rare, mucinous cystadenocarcinoma of the pancreas is an established pathological entity. However, its characteristic features on diagnostic imaging have not yet been defined. Based upon clinicopathological studies on 5 cases, two subgroups of mucinous cystadenocarcinoma of the pancreas are proposed: the endophytic and the exophytic types.
The former consist of large well-demarcated cystic tumors with numerous inward-growing cauliflower-like excrescences in mucinous material, which were characteristically demonstrated either by CT or ultrasonography. Tumors of this subtype were visualized as hypervascular masses in the capillary phase of angiography. Areas of malignant tissue were well-demarcated without capsular invasion, and tumors were free from lymph node or distant metastasis.
Though cystic, the exophytic subtype had negligible inward-growing papillary projections. Corresponding to their macroscopic features, these tumors were demonstrated as cystic lesions lacking papillary projections on ultrasonography or CT. No tumor stains could be demonstrated by angiography. Despite of their smaller size than the former subtype, cancerous growth penetrated through the cyst wall and metastasized to lymph nodes, causing poorer prognosis than in the former.
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References
Becker WF, et al: Cystadenoma and cystadenocarcinoma of the pancreas. Ann Surg 161: 845, 1965
Cubilla AL, et al: Malignant Neoplasms. Tumor of the exocrine pancreas, p 109, edited by Cubilla AL and Fitzgerald PJ, Armed Forces Institute of Pathology, Washington, D.C., 1984
Chen J, et al: Morphological study of 391 cases of exocrine pancreatic tumors with special reference to the classification of exocrine pancreatic carcinoma, Pathol 146: 17, 1985
Okumura S, et al: Japanese resistration of pancreatic canceranalysis of 3080 cases during 3 years-. The Biliary Tract & Pancreas 6: 1051, 1985 (Jpn)
Compagno J, et al: Mucinous cystic neoplasm of the pancreas with overt and latent malignancy (cystadenoma and cystadenocarcinoma). Am J Clin Pathol 69: 573, 1978
Hodgkinson DJ, et al: A clinicopathologic study of 21 cases of pancreatic cystadenocarcinoma. Ann Surg 188: 679, 1978
Compagno J, et al: Microcystic adenoma of the pancreas (Glycogen-rich cystadenoma)-clinicopathologic study of 34 cases-. Am J Clin Pathol 69: 289, 1978
Hodgkinson DJ, et al: Pancreatic cystadenomaa clinicopathologic study of 45 cases-. Arch Surg 113: 512, 1978
Itai Y, et al: Computed tomography of cystadenoma and cystadenocarcinoma of the pancreas. Radiology 145: 419, 1982
Freeny PC, et al: Cystic neoplasms of the pancreas New angiographic and ultrasonographic findings. Am J Roentgenol 131: 795, 1978
Friedman AC, et al: Cystic neoplasms of the pancreas — Radiological-Pathological correlation —. Radiology 149: 45, 1983
Abrams RM, et al: Angiographic studies of benign and malignant cystadenoma of the pancreas. Radiology 89: 1028, 1967.
Uflacker R, et al: Angiography in cystadenoma and cystadenocarcinoma of the pancreas. Acta Radiologica Diagnosis 21: 189, 1978
Cullen PK, et al: A clinicopathological study of cystadenocarcinoma of the pancreas. Surg Gynecol Obstet 117: 189, 1963
Warren KW, et al: Cystadenocarcinoma of the pancreas. Surg Gynecol Obstet 127: 734, 1968
Hyde GL, et al: Mucinous cystic neoplasm of the pancreas with latent malignancy. The American Surgeon 50: 225, 1984
Taft DA, et al: Cystic neoplasms of the pancreas. Am J Surg 142: 30, 1981
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Fukumoto, T., Kasahara, K., Hirota, N. et al. Clinicopathological study on cystadenocarcinoma of the pancreas. Gastroenterol Jpn 22, 63–73 (1987). https://doi.org/10.1007/BF02806336
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DOI: https://doi.org/10.1007/BF02806336