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The concentration of twelve elements in the anterior pituitary from human subjects and rats as measured by particle induced X-ray emission (PIXE)

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Abstract

The concentration of twelve elements—potassium, calcium, manganese, iron, cobalt, nickel, copper, zinc, arsenic, selenium, bromine, and rubidium—in anterior pituitaries from human subjects and rats was measured using Particle Induced X-ray Emission (PIXE). The human material included anterior pituitaries from 37 normal human subjects, 27 males and 10 females, all of whom died from traumatic lesions. Excluded from the investigations were persons with alcohol abuse, regular use of drugs, and babies younger than 1 year.

For selenium, zinc, bromine, and to some extent copper, there was good correlation between the amounts found in anterior pituitaries from rats and human subjects. A significant difference between male and female rat pituitaries was observed for copper, iron, and rubidium, whereas for humans significant difference was only observed for manganese. Anterior pituitaries from human females contained generally more zinc than male glands, but the concentration of zinc in young males was higher than in females. The present study also indicates age related differences in the copper content in anterior pituitaries from human subjects, since pituitaries from humans between 15–45 years contained 25% more copper than those from younger or older persons. The opposite pattern was observed in males. For such elements as Cu, Fe, Mn, and Se, the content in the anterior pituitary from human subjects was 1.6–2 times that stated for other endocrine organs.

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References

  1. H. L. Fevold, F. L. Hisaw, and R. Greep,Am. J. Physiol. 117, 68 (1936).

    CAS  Google Scholar 

  2. P. Petrusz, C. M. Weaver, L. D. Grant, P. Mushak, and M. R. Krigman,Environ. Res. 19, 383 (1979).

    Article  PubMed  CAS  Google Scholar 

  3. H. H. Sandstead, D. N. Orth, K. Abe, and J. Stiel,Clin. Res. 18, 76 (1970).

    Google Scholar 

  4. F. S. LaBella, R. Dular, P. Lemon, S. Vivian, and G. Queen,Nature 245, 330 (1973).

    Article  PubMed  CAS  Google Scholar 

  5. F. Labella, R. Dular, S. Vivian, and G. Queen,Biochem. Biophys. Res. Commun. 52, 786 (1973).

    Article  PubMed  CAS  Google Scholar 

  6. M. Y. Lorenson, D. L. Robson, and L. S. Jacobs,J. Biol. Chem. 258, 8618 (1983).

    PubMed  CAS  Google Scholar 

  7. A. A. Lamperti and R. H. Prinz,Biol. Reprod. 11, 180 (1974).

    Article  PubMed  CAS  Google Scholar 

  8. B. Møller-Madsen and O. Thorlacius-Ussing,Virchows Arch. (Cell Pathol.) 51, 303 (1986).

    Article  Google Scholar 

  9. O. Thorlacius-Ussing, B. Møller-Madsen, and G. Danscher,Exp. Mol. Pathol. 42, 278 (1985).

    Article  PubMed  CAS  Google Scholar 

  10. S. K. Saksena, L. Dahlgren, I. F. Lau, and M. C. Chang,Biology of Reproduction 16, 609 (1977).

    Article  PubMed  CAS  Google Scholar 

  11. G. J. Everson, L. S. Hurley, and J. F. Geiger,J. Nutr. 68, 49 (1959).

    PubMed  CAS  Google Scholar 

  12. A. M. Judd, R. M. MacLeod, and I. S. Login,Brain Res. 294, 190 (1984).

    Article  PubMed  CAS  Google Scholar 

  13. S. K. Mahajan, R. J. Hamburger, W. Flamenbaum, A. S. Prasad, and F. D. McDonald,Lancet ii, 750 (1985).

    Article  Google Scholar 

  14. M. J. Millar, M. I. Fischer, P. V. Elcoate, and C. A. Mawson,Can. J. Biochem. Physiol. 36, 557 (1958).

    PubMed  CAS  Google Scholar 

  15. A. W. Root, G. Duckett, M. Sweetland, and E. O. Reiter,J. Nutr. 109, 958 (1979).

    PubMed  CAS  Google Scholar 

  16. O. Thorlacius-Ussing,Neuroendocrinology 45, 233 (1987).

    PubMed  CAS  Google Scholar 

  17. O. Thorlacius-Ussing and G. Danscher,Toxicol. Appl. Pharmacol. 59, 67 (1985).

    Article  Google Scholar 

  18. O. Thorlacius-Ussing, A. Flyvbjerg, and J. Esmann,Endocrinology 120, 659 (1987).

    Article  PubMed  CAS  Google Scholar 

  19. O. Thorlacius-Ussing, A. Flyvbjerg, and H. Ørskov,Toxicology,48, 167 (1988).

    Article  PubMed  CAS  Google Scholar 

  20. R. I. Henkin,Med. Clin. North Amer. 60, 779 (1976).

    CAS  Google Scholar 

  21. T. W. Clarkson, G. F. Nordberg, and P. R. Sager,Reproductive and Developmental Toxicity of Metals, Plenum, New York and London, 1983, pp. 1–205.

    Google Scholar 

  22. G. R. Merriam, L. L. Nunnelley, J. W. V. Trish, and F. Naftolin,Brain Res. 171, 503 (1979).

    Article  PubMed  CAS  Google Scholar 

  23. M. Y. Lorenson and L. S. Jacobs,Excerpta Med. Int. Congr. Ser. 652, 1050 (1984).

    Google Scholar 

  24. E. L. Kanabrochi, J. Greco, L. A. Graham, E. Kaplan, M. E. Rubnitz, Y. T. Oester, S. Brar, P. S. Gustafson, D. M. Nelson, F. Malinari, C. E. Moore, and J. A. Kanabrochi,Int. J. Nucl. Med. Biol. 3, 73 (1976).

    Article  Google Scholar 

  25. T. B. Johansson, R. Akselsson, and S. A. E. Johansson,Nucl. Instr. Meth. 84, 141 (1970).

    Article  CAS  Google Scholar 

  26. W. Koenig, F. W. Richter, U. Steiner, R. Stock, R. Thielman, and U. Wätjen,Nucl. Instrum. Meth. 142, 225 (1977).

    Article  CAS  Google Scholar 

  27. G. I. Johansson,X-ray Spectrometry 11, 194 (1982).

    Article  CAS  Google Scholar 

  28. N. Hertel,Nucl. Instr. Meth. B 14, 58 (1986).

    Article  Google Scholar 

  29. W. J. Dixon,BMDP Statistical Software, University of California Press, Berkeley, 1983.

    Google Scholar 

  30. S. A. E. Johansson and T. B. Johansson,Nucl. Instr. Meth. 137, 473 (1976).

    Article  CAS  Google Scholar 

  31. N. Hertel and O. Thorlacius-Ussing,Nucl. Instr. Meth. B 22, 149 (1987).

    Article  Google Scholar 

  32. G. W. Iyengar, W. E. Kollmer, and H. J. M. Bowen,The Elemental Composition of Human Tissues and Body Fluids, Verlag Chemie, Weinheim, New York, 1978.

    Google Scholar 

  33. H. J. M. Bowen, inTrace Elements in Biochemistry, H. J. M. Bowen, ed., Academic, London, 1966, pp. 61–84.

    Google Scholar 

  34. E. I. Hamilton, M. J. Minski, and J. J. Cleary,Sci. Total Environ. 1, 341 (1972/1973).

    Article  Google Scholar 

  35. N. Ishinishi, K. Tsuchiya, M. Vahter, and B. Fowler, inHandbook on the Toxicology of Metals, 2nd ed., L. Friberg, G. F. Nordberg, and V. Vouk, eds., Elsevier, Amsterdam 1986, pp. 43–83.

    Google Scholar 

  36. S. K. Mahajan, A. A. Abbasi, A. S. Prasad, P. Rabbani, W. A. Briggs, and F. D. McDonald,Ann. Intern. Med. 97, 357 (1982).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Anatomy (Neurobiology), University of Aarhus, DK-8000, Aarhus C, Denmark

    O. Thorlacius-Ussing

  2. Institute of Forensic Medicine, University of Aarhus, DK-8000, Aarhus C, Denmark

    M. Gregersen

  3. Institute of Physics, University of Aarhus, DK-8000, Aarhus C, Denmark

    N. Hertel

Authors
  1. O. Thorlacius-Ussing
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  2. M. Gregersen
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  3. N. Hertel
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Thorlacius-Ussing, O., Gregersen, M. & Hertel, N. The concentration of twelve elements in the anterior pituitary from human subjects and rats as measured by particle induced X-ray emission (PIXE). Biol Trace Elem Res 16, 189–202 (1988). https://doi.org/10.1007/BF02797135

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  • DOI: https://doi.org/10.1007/BF02797135

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