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Some differentiating effects of selenium on the cultured human hepatoma cells and human pulmonary adenocarcinoma cells in vitro

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Abstract

Two human hepatoma cell lines, QGY-7703 and SMMC-7721, and two human pulmonary adenocarcinoma cell lines, LTEP-a-2 and SPC-A-1, were found to respond to 1 μg/mL Na2SeO3, 24 h, in-vitro treatment by decreasing its confluent saturation density. The same treatment was found to cause an increase in the adhesiveness of cells measured as resistance to detachment by trypsin/EDTA. The pathological features of tumors after heterotransplantation of treated and untreated cells were similar, but the size of tumor grown from treated cells was much smaller.

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Authors and Affiliations

  1. Cancer Institute, Chinese Academy of Medical Sciences, Beijing, China

    Ao Pung, Zhao Mei & Shu-Yu Yu

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  1. Ao Pung
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  2. Zhao Mei
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  3. Shu-Yu Yu
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Pung, A., Mei, Z. & Yu, SY. Some differentiating effects of selenium on the cultured human hepatoma cells and human pulmonary adenocarcinoma cells in vitro. Biol Trace Elem Res 14, 19–27 (1987). https://doi.org/10.1007/BF02795593

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  • DOI: https://doi.org/10.1007/BF02795593

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