Abstract
To check the proposed hypothesis that the relative content of individual polyunsaturated fatty acids (PUFAs)—substrates and inhibi tors of prostanoid synthesis—in plasma can be regarded as a quantita tive risk factor of blood clotting, a test was conducted on free fatty acids content in blood plasma of healthy people (group 0) and patients with heart ischemia before (group 1) and after (group 2) they were treated for a month with a food additive called “Eiconol,” enriched with PUFA ω3. Different proportions of PUF As have been calculated in all cases, accounting for the contribution of each acid to the process of primary clotting. Comparison of PUFA rations among the three groups showed significant differences of means between groups 0 and 1 and also group 1 and 2 for 6 out of 7 proposed coefficients, which disappeared after “Eiconol” treatment (comparison of groups 0 and 2). The results led to the conclusion that out of the proposed PUFA proportions, the coefficients describing the relative content of arachidonic acid in blood plasma may be the most informative for diagnosis and treatment efficiency in evaluation of heart and vascular diseases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Moncada, S. (1985),J. Pharmacol. 16, suppl., 71–88.
Dyerberg, J., Bang, H. O., Moncada, S., and Vane, J. R. (1978),Lancet 2, 117–119.
Virgolini, I., O’Grady, J., Peskar, B. A., and Sinzinger, H. (1990),Prostaglandins, Leukotriences and Essential Fatty Acids. 40, 227–237.
Mevkh, A. T., Yuscovitch, A. K., Duzgenco, B. S., Lee, E. D., and Lakin, K. M. (1990),Kardiologia 9, 54–57 (in Russian).
Diszfalury, U. and Hammarstrom, S. (1979),FEBS Lett. 10, 291–295.
Needleman, P., Raz, A., Minkes, M. S., Ferrendelli, J. A., and Sprecher, H. (1979),Proc. Natl. Acad. Sci. USA 76, 944–948.
Corey, E. J., Shin, C., and Cashman, J. B. (1983),Proc. Natl. Acad. Sci. USA 80, 3581–3584.
Hagenfeldt, L. (1966),Clin. Chim. Acta. 13, 266–268.
Yuscovich, A. K. (1985),Lab. delo 10, 488–490 (in Russian).
Karagodina, Z. V., Korf, I. I., Lupinovich, V. L., Levacheov, V. L., and Volgarev, M. N. (1993),Bull. Exp. Biol. Med. 11, 499–502 (in Russian).
Fischer, S., Schacky, C., and Siess, W. (1984),Biochem. Biophys. Res. Commun. 120, 907–918.
Nordy, A., Lyngmo, V., Vartun, A., and Svensson, B. (1986),Biochim. Biophys. Acta. 877, 31–36.
Kondo, T., Ogawa, K., Satake, T., Kitazawa, M., Taki, K., Sugiyama, S., and Ozawa, T. (1986),Clin. Cardiol. 9, 413–416.
Nakamura, N., Hamazaki, T., Yamazaki, K., Taki, H., Kobayashi, M., Yazawa, K., and Ibuki, F. (1993),J. Clin. Invest. 92, 1253–1261.
Parent, C. A., Lagarde, M., Venton, D. L., and Le Breton, G. C. (1992),J. B. C. 267, 6541–6547.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mevkh, A.T., Yuskovich, A.K., Duzhenko, V.S. et al. Ratios of substrates and inhibitors of prostaglandin synthesis in blood plasma of atients with heart ischemia. Appl Biochem Biotechnol 61, 199–204 (1996). https://doi.org/10.1007/BF02785702
Issue Date:
DOI: https://doi.org/10.1007/BF02785702