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Effect of zinc on cadmium influx and toxicity in cultured CHO cells

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Abstract

Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.109Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common transport mechanism. Thus, the antagonism appears to involve a reduction in the influx of cadmium due to the presence of zinc.

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Authors and Affiliations

  1. Department of Biochemistry, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, 21205, Baltimore, Maryland

    P. C. Huang, Betty Smith, Patricia Bohdan & Alice Corrigan

Authors
  1. P. C. Huang
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  2. Betty Smith
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  3. Patricia Bohdan
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  4. Alice Corrigan
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Huang, P.C., Smith, B., Bohdan, P. et al. Effect of zinc on cadmium influx and toxicity in cultured CHO cells. Biol Trace Elem Res 2, 211–220 (1980). https://doi.org/10.1007/BF02785356

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  • DOI: https://doi.org/10.1007/BF02785356

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