Abstract
The time course of iodine excretion in adult male rats substantially differs from bromine excretion. Bromine is excreted at a single rate, whereas iodine evinces two excretion rates. Even a strong increase in bromide intake in experimental animals failed to affect the rate of iodine excretion but it lowered the fraction of iodine accumulated increase in bromide intake in experimental animals failed to affect the rate of iodine excretion but it lowered the fraction of iodine accumulated in the thyroid gland by 20% probably by affecting the transport of iodide into the thyroid gland.
Similar content being viewed by others
References
A. G. Rauws, Pharmacokinetics of bromide ion—an overview,Fd. Chem. Toxic. 21, 379–382 (1983).
F. X. Rolaf van Leeuven, B. Sangster,The Toxicology of Bromide Ion, CRC Critical Reviews in Toxicology, vol. 18, pp. 189–213 (1987).
M. Vobecky and A. Babicky, Effect of enhanced bromide intake on the concentration ratio I/Br in the rat thyroid gland,Biol. Trace Element Res,43-45, 509–516 (1994).
B. Singh, D. Dhawan, B. Chand, and P. C. Mangal, Biokinetics of Iodine-131 in rat thyroid following lead and lithium supplementation.Biol. Trace Element Res. 40, 287–293 (1994).
A. G. Rauws and M. J. van Logten, The influence of dietary chloride on bromide excretion in the rat,Toxicology 3, 29–32 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vobecky, M., Babicky, A. & Lener, J. Effect of increased bromide intake on iodine excretion in rats. Biol Trace Elem Res 55, 215–219 (1996). https://doi.org/10.1007/BF02785280
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02785280