Abstract
Analytical ion microscopy (AIM) was used to determine alterations in the thyroid follicular lumen127I stores of Wistar rats injected with different doses of129I (low specific activity radionuclide). Animals fed a normal iodine diet (10 μg127I/d) were divided into four groups: control group and three treated groups injected ip 24 h before sacrifice with129I at doses of 10 μg (group 1), 30 μg (group 2), and 8500 μg (group 3). AIM was performed on thyroid semithin sections. The mean129I concentration increased with the dose injected from group 1 (0.44±0.03 μg/mg, mean ± SEM) to group 2 (2.05±0.14 μg/mg) and decreased in group 3 (0.57±0.08 μg/mg). When compared to control group (4.14±0.17 μg/mg), the mean127I concentration was not changed in group 1 (4.52±0.07 μg/mg), but altered in the other groups: It was significantly increased (7.14±0.41 μg/mg) in group 2 and slightly decreased (3.11±0.26 μg/mg) in group 3. These results underline the interest of AIM in the study of the effects of various doses of iodide on the thyroid autoregulation by iodide, a trace element actively trapped by this gland.
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Briançon, C., Halpern, S., Jeusset, J. et al. Acute effects of various doses of iodide on thyroid iodine autoregulation. Biol Trace Elem Res 32, 267–273 (1992). https://doi.org/10.1007/BF02784610
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DOI: https://doi.org/10.1007/BF02784610