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Absorption and metabolism of oral zinc gluconate in humans in fasting state, during, and after a meal

  • Part 2: Trace elements in endocrinology
  • Section 1: General
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Abstract

The absorption and metabolism of zinc in a commercial form for oral use (Rubozinc®, 15 mg zinc as gluconate) were investigated in 10 subjects by a kinetic study of the serum zinc profile after administration of 45 mg zinc under three conditions: after an overnight fast, during a standardized breakfast, and 2 h after this meal. The pharmacokinetic parameters were calculated by a method suitable to the characterization of rebound effects (recycling of the element in the gastrointestinal tract). In fasting state, the parameters were comparable to those previously collected in the same subjects with oral 45 mg zinc as sulfate, except with very significantly higherC max and area under curve (AUC), showing a better bioavailability for zinc in the commercial form. The light meal perturbed the absorption process as evidenced by the significant increases in the lag time (+180%), thet max (+57%), and the lag times for the first two cycles during the meal. However, the parameters returned to normal values 2 h after the meal. TheC max only moderately decreased during the meal (31%) as did the AUC (−28%). An important delay in the absorption of zinc in the commercial form when taken during a meal was therefore demonstrated, but the effect on zinc bioavailability was only moderate.

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Authors and Affiliations

  1. Department of Pharmaceutical Organic Chemistry, Institute of Pharmacy, Free University of Brussels, Campus Plaine 205-5, B-1050, Brussels, Belgium

    Jean Nève

  2. Toxicology and Bioanalytical Chemistry Unit, Institute of Pharmacy, Free University of Brussels, Campus Plaine 205-1, B-1050, Brussels, Belgium

    Michel Hanocq

  3. Department of Rheumatology and Physical Medicine, Saint-Pierre Hospital, Free University of Brussels, rue Haute, 322, B-1000, Brussels, Belgium

    Anne Peretz

  4. Society Sofimath, avenue Louise, 419, B-1050, Brussels, Belgium

    Fakhri Abi Khalil

  5. Labcatal Laboratory, rue Roger Salengro 7, BP 305, F-92541, Montrouge Cédex, France

    Francois Pelen

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  1. Jean Nève
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  2. Michel Hanocq
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  3. Anne Peretz
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  4. Fakhri Abi Khalil
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  5. Francois Pelen
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Nève, J., Hanocq, M., Peretz, A. et al. Absorption and metabolism of oral zinc gluconate in humans in fasting state, during, and after a meal. Biol Trace Elem Res 32, 201–212 (1992). https://doi.org/10.1007/BF02784604

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  • DOI: https://doi.org/10.1007/BF02784604

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