Advertisement

Biological Trace Element Research

, Volume 32, Issue 1–3, pp 201–212 | Cite as

Absorption and metabolism of oral zinc gluconate in humans in fasting state, during, and after a meal

  • Jean Nève
  • Michel Hanocq
  • Anne Peretz
  • Fakhri Abi Khalil
  • Francois Pelen
Part 2: Trace elements in endocrinology Section 1: General

Abstract

The absorption and metabolism of zinc in a commercial form for oral use (Rubozinc®, 15 mg zinc as gluconate) were investigated in 10 subjects by a kinetic study of the serum zinc profile after administration of 45 mg zinc under three conditions: after an overnight fast, during a standardized breakfast, and 2 h after this meal. The pharmacokinetic parameters were calculated by a method suitable to the characterization of rebound effects (recycling of the element in the gastrointestinal tract). In fasting state, the parameters were comparable to those previously collected in the same subjects with oral 45 mg zinc as sulfate, except with very significantly higherC max and area under curve (AUC), showing a better bioavailability for zinc in the commercial form. The light meal perturbed the absorption process as evidenced by the significant increases in the lag time (+180%), thet max (+57%), and the lag times for the first two cycles during the meal. However, the parameters returned to normal values 2 h after the meal. TheC max only moderately decreased during the meal (31%) as did the AUC (−28%). An important delay in the absorption of zinc in the commercial form when taken during a meal was therefore demonstrated, but the effect on zinc bioavailability was only moderate.

Index Entries

Zinc gluconate absorption distribution metabolism pharmacokinetics bioavailability cycle recirculation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    K. M. Hambidge, C. E. Casey, and N. F. Krebs,Trace Elements in Human and Animal Nutrition, vol. 2, W. Mertz, ed., Academic, Orlando, FL, 1986, pp. 1–137.Google Scholar
  2. 2.
    A. Favier,Le Zinc en Médecine et en Biologie, A. Favier, J. Arnaud, and H. Faure, eds., Editions Médicales Internationales, Paris, 1987, pp. 3–20.Google Scholar
  3. 3.
    J. Nève and A. Peretz,J. Pharm. Belg. 43, 466 (1988).PubMedGoogle Scholar
  4. 4.
    R. J. Cousins,Physiol. Rev. 65, 238 (1985).PubMedGoogle Scholar
  5. 5.
    A. S. Prasad,Ann. Rev. Nutr. 5, 341 (1985).CrossRefGoogle Scholar
  6. 6.
    H. Ronaghy,Wld. Rev. Nutr. Diet. 54, 237 (1987).Google Scholar
  7. 7.
    B. Dreno, P. Amblard, P. Agache, S. Sirot, and P. Litoux,Acta Derm. Venerol. 69, 541 (1989).PubMedGoogle Scholar
  8. 8.
    C. L. Keen and M. E. Gershin,Ann. Rev. Nutr. 10, 415 (1990).CrossRefGoogle Scholar
  9. 9.
    C. H. Cho,Drug Develop. Rev. 17, 185 (1989).CrossRefGoogle Scholar
  10. 10.
    G. Escolar and O. Bulbena,Drugs Expl. Clin. Res. 15, 83 (1989).Google Scholar
  11. 11.
    G. A. Eby, D. R. Davis, and W. W. Halcomb,Antimicrob. Agents Chemotherap. 25, 20 (1984).Google Scholar
  12. 12.
    G. Hill, J. Brewer, A. S. Prasad, C. Hydrick, and D. Hartmann,Hepatol. 7, 522 (1987).CrossRefGoogle Scholar
  13. 13.
    G. Hill, J. Brewer, J. Juni, A. S. Prasad, and R. D. Dick,Am. J. Med. Sci. 29, 344 (1986).CrossRefGoogle Scholar
  14. 14.
    National Research Council, Recommended Dietary Allowances, 10th ed., National Academy Press, Washington, 1989.Google Scholar
  15. 15.
    P. B. Moser and C. J. Gundeson, (1982),Nutr. Res. 3, 279.CrossRefGoogle Scholar
  16. 16.
    J. J. Keyzer, E. Oosting, B. G. Wolthers, and F. Muskiet,Pharm. Weekbl. 5, 252 (1983).Google Scholar
  17. 17.
    A. Pecoud, P. Conzel, and J. L. Schelling,Clin. Pharmacol. Ther. 17, 469 (1975).PubMedGoogle Scholar
  18. 18.
    F. J. Oelshlegel and G. J. Brewer,Zinc Metabolism, Current Aspects in Health and Disease, G. J. Brewer and A. S. Prasad, eds., Alan R. Liss, New York, 1977, pp. 299–311.Google Scholar
  19. 19.
    J. Nève, M. Hanocq, A. Peretz, F. Abi Khalil, F. Pelen, J. P. Famaey, and J. Fontaine,Eur. J. Drug. Metabl. Pharmacokin, in press (1991).Google Scholar
  20. 20.
    J. C. Smith, J. T. Holbrook, and D. E. Danford,J. Am. Coll. Nutr. 4, 627 (1985).PubMedGoogle Scholar
  21. 21.
    J. Nève, L. Molle, M. Hanocq, P. M. Sinet, and R. Van Geffel,Biol. Trace Elem. Res. 5, 75 (1983).CrossRefGoogle Scholar
  22. 22.
    A. Peretz, J. Nève, and J. P. Famaey,J. Trace Elem. Electrolytes Health Dis. 3, 103 (1989).PubMedGoogle Scholar
  23. 23.
    J. Versieck, L. Vanballenberghe, A. De Kessel, J. Hoste, B. Wallaeys, J. Vandenhaute, N. Baeck, A. Steyaert, J. Byrne, and F. Sunderman,Clin. Chim. Acta 204, 63 (1988).Google Scholar
  24. 24.
    E. Couturier, A. van Onderbergen, D. Bosson, and J. Nève,J. Trace Elem. Electrolytes Health Dis. 2, 245 (1988).PubMedGoogle Scholar
  25. 25.
    F. Abi Khalil, J. Dubois, M. Hanocq, and G. Atassi,Eur. J. Drug Metab. Pharmacokin. 11, 51 (1986).CrossRefGoogle Scholar
  26. 26.
    F. Abi Khalil, M. Hanocq, and J. Dubois,Eur. J. Drug. Metab. Pharmacokin. in press (1991).Google Scholar
  27. 27.
    G. W. Snedecor, and W. G. Cochran,Statistical Methods 7th ed. Iowa State University, Ames, IA, 1980.Google Scholar
  28. 28.
    M. G. Kendall and A. Stewart,The Advanced Theory of Statistics, vol. 2., Griffin and Co., London, 1968.Google Scholar
  29. 29.
    S. S. Southon, S. J. Fairweather-Tait, and T. Hazell,Proc. Nutr. Soc. 47, 27 (1988).PubMedCrossRefGoogle Scholar
  30. 30.
    R. Aamodt, W. Rumble, G. Johnston, E. Markley, and R. Henkin,Am. J. Clin. Nutr. 32, 559 (1979).PubMedGoogle Scholar
  31. 31.
    R. Aamodt, W. Rumble, A. Babcock, D. Foster, and R. Henkin,Metab. 31, 326 (1982).CrossRefGoogle Scholar
  32. 32.
    J. Turnlund, N. Durkin, F. Costa, and S. Margen,J. Nutr. 116, 1239 (1986).PubMedGoogle Scholar
  33. 33.
    M. Wastney and R. Henkin,J. Nutr. 119, 1438 (1989).PubMedGoogle Scholar
  34. 34.
    L. S. Valberg, P. Flanagan, J. Brennan, and M. Chamberlain,Am. J. Clin. Nutr. 41, 37 (1985).PubMedGoogle Scholar
  35. 35.
    J. P. Labaune,Handbook of Pharmacokinetics, Ellis Horwood, Chichester, 1989.Google Scholar
  36. 36.
    J. G. Wagner,Biopharmaceutics and Relevant Pharmacokinetics, Drug Intelligence, Hamilton, IL, 1971.Google Scholar
  37. 37.
    S. A. Barrie, J. V. Wright, J. E. Pissorno, E. Kutter, and P. C. Barron,Agents Actions 21, 223 (1987).PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • Jean Nève
    • 1
  • Michel Hanocq
    • 2
  • Anne Peretz
    • 3
  • Fakhri Abi Khalil
    • 4
  • Francois Pelen
    • 5
  1. 1.Department of Pharmaceutical Organic Chemistry, Institute of PharmacyFree University of BrusselsBrusselsBelgium
  2. 2.Toxicology and Bioanalytical Chemistry Unit, Institute of PharmacyFree University of BrusselsBrusselsBelgium
  3. 3.Department of Rheumatology and Physical Medicine, Saint-Pierre HospitalFree University of BrusselsBrusselsBelgium
  4. 4.Society SofimathBrusselsBelgium
  5. 5.Labcatal LaboratoryMontrouge CédexFrance

Personalised recommendations