Skip to main content
SpringerLink
Log in

Plasma and erythrocyte manganese concentrations

Influence of age and acute myocardial infarction

  • Original Articles
  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

This study was carried out to assess manganese (Mn) status after an acute episode of myocardial infarction. Plasma and erythrocyte Mn concentrations were measured from admission to hospital to day 15 postadmission in 21 patients suffering from acute myocardial infarction and in three control groups. The determination of Mn in these biological fluids was performed by electrothermal atomic absorption spectrometry. Plasma Mn was higher (p<0.01) and erythrocyte Mn was similar in the acute myocardial infarction group compared to healthy age-matched control group. Plasma and erythrocyte Mn remained unchanged during the 2 wk after acute myocardial infarction and were not correlated to enzyme activities. A decrease of erythrocyte Mn with age, expressed in nmol/L, was noted (p<0.02). These results suggest that plasma and erythrocyte Mn do not provide an indication of myocardial damage. Nonetheless, Mn status in elderly merits further attention.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. W. B. Kannel, New perspectives on cardiovascular risk factors,Am. Heart J. 114, 213–219 (1987).

    Article  PubMed  CAS  Google Scholar 

  2. R. A. Riemersma, Epidemiology and the role of antioxidants in preventing coronary heart disease: a brief overview,Proc. Nutr. Soc. 53, 59–65 (1994).

    Article  PubMed  CAS  Google Scholar 

  3. C. L. Keen, B. Lönnerdal and L. S. Hurley, Manganese, inBiochemistry of the Essential Ultratrace Elements, E. Frieden, ed., Plenum, New York, pp. 89–132 (1984).

    Google Scholar 

  4. J. Manthey, M. Stoepper, W. Morgenstern, E. Nüssel, D. Opherk, A. Weintraut, H. Wesch and W. Kubler, Magnesium and trace metals: risk factors for coronary heart disease? Associations between blood levels and angiographic findings.Circulation 64, 722–729 (1981).

    PubMed  CAS  Google Scholar 

  5. M. Kuhn, H. S. Holtmeier, and J. Mertz, Serum manganese and copper levels in myocardial infarction, inTraces Substances in Environmental Health, vol. XII, D. D. Hemphill, ed., University of Missouri, Columbia, pp. 180–184 (1978).

    Google Scholar 

  6. J. Versieck, F. Barbier, A. Speecke and J. Hoste, Influence of myocardial infarction on serum manganese, copper, and zinc concentrations,Clin. Chem. 21, 578–581 (1975).

    PubMed  CAS  Google Scholar 

  7. H. Zumkley, H. Vetter, H. P. Bertram, B. Tank, and W. Wirth, Plasma zinc and magnesium alterations in acute myocardial infarction,Klin. Wochenschr. 58, 1143–1146 (1980).

    Article  PubMed  CAS  Google Scholar 

  8. J. Versieck, L. Vanballenberghe, A. De Kesel, J. Hoste, B. Wallaeys, J. Vandenhaute, N. Baeck, H. Steyaert, A. R. Byrne and F. W. Sunderman, Certification of a second-generation biological reference material (freeze-dried human serum) for trace element determinations,Anal. Chim. Acta 204, 63–75 (1988).

    Article  CAS  Google Scholar 

  9. A. Favier, D. Ruffieux, A. Alcaraz and B. Maljournal, Flameless atomic absorption assay of serum manganese,Clin. Chim. Acta 124, 239–244 (1982).

    Article  PubMed  CAS  Google Scholar 

  10. J. Nève and N. Leclercq, Factors affecting determinations of manganese in serum by atomic absorption spectrometry,Clin. Chem. 37, 723–728 (1991).

    PubMed  Google Scholar 

  11. J. Versieck, F. Barbier, J. Hoste, R. Cornelis and J. De Rutter, Manganese in serum,Talanta 23, 745–745 (1976).

    Article  CAS  Google Scholar 

  12. D. B. Milne, R. L. Sims and N. V. C. Ralston, Manganese content of the cellular components of blood,Clin. Chem. 36, 450–452 (1990).

    PubMed  CAS  Google Scholar 

  13. S. Hatano, Y. Nishi and T. Usui, Erythrocyte manganese concentration in healthy Japanese children, adults, and the elderly, and in cord blood,Am. J. Clin. Nutr. 37, 457–460 (1983).

    PubMed  CAS  Google Scholar 

  14. A. M. Scheuhammer and M. G. Cherian, Binding of manganese in human and rat plasma,Biochim. Biophys. Acta 840, 163–169 (1985).

    PubMed  CAS  Google Scholar 

  15. A. Usui, K. Kato, H. Tsuboi, T. Sone, H. Sassa and T. Abe, Concentration of Mn-superoxide dismutase in serum in acute myocardial infarction,Clin. Chem. 37, 458–461 (1991).

    PubMed  CAS  Google Scholar 

  16. I. Durak, O. Akyol, O. Canbolat and S. Büyükberber, Mn- and Cu,Zn-superoxide dismutase activities during acute myocardial infarction,Clin. Chem. 39, 911–912 (1993).

    PubMed  CAS  Google Scholar 

  17. S. A. Katz, Collection and preparation of biological tissues and fluids for trace element analysis,I.C.P.R. July/August, 13–19 (1985).

    Google Scholar 

  18. B. J. Martin, T. D. B. Lyon and G. S. Fell, Comparison of inorganic elements from autopsy tissue of young and elderly subjects,J. Trace Element Electrolytes Health Dis. 5, 203–211 (1991).

    CAS  Google Scholar 

  19. A. Hunnisett, J. Howard and S. Davies, A new functional test of manganese status,J. Nutr. Med. 1, 209–215 (1990).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Biochimie C, CHUG, BP 217, 38043, Grenoble Cedex 9, France

    Josiane Arnaud & Alain E. Favier

  2. Service de Cardiologie et Urgences cardiologiques, Unité de soins intensifs, CHUG Grenoble, France

    Pierre Bourlard & Bernard Denis

Authors
  1. Josiane Arnaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pierre Bourlard
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bernard Denis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alain E. Favier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arnaud, J., Bourlard, P., Denis, B. et al. Plasma and erythrocyte manganese concentrations. Biol Trace Elem Res 53, 129–136 (1996). https://doi.org/10.1007/BF02784550

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02784550

Index Entries

Search

Navigation