Skip to main content
SpringerLink
Log in

Interleukin-1α-induced changes in chromium-51 absorption, tissue retention, and urinary excretion in rats

  • Original Articles
  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

The effects of interleukin-1 alpha (IL-1α) on chromium-51 absorption, tissue retention, and urinary excretion were studied in adult male Sprague-Dawley rats. Ten rats were deprived of food for 12 h, injected intraperitoneally with mouse recombinant IL-1α (1 Μg/kg of body weight in phosphate-buffered saline [PBS]) or control (0.1% bovine serum albumin [BSA] in PBS). Two hours after dosing with the IL-1α, rats were fed 50 ΜL (200 ΜCi, 0.36 Μg Cr) of51CrCl3 by micropipet. Blood was collected from the tail at 0.25, 0.5, 1, 2, and 4 h. Six hours after dosing with51CrCl3, rats were exsanguinated and blood and tissues were sampled. The IL-lα significantly decreased chromium-51 in blood, urine, and some tissues compared to the control. The decreased absorption, retention, and urinary excretion of chromium-51 from51CrCl3 in this study may be due to IL-1α-mediated increases in the production of prostaglandins and/or decreased production of gastric acid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. Gauldie and H. Baumann, Cytokines and acute phase protein expression, inCytokines and Inflammation, E. S. Kimball, ed., CRC, Boca Raton, FL, pp. 275–305 (1991).

    Google Scholar 

  2. C. A. Dinarello, Biology of interleukin 1,FASEB J. 2, 108–115 (1988).

    PubMed  CAS  Google Scholar 

  3. A. Robert, A. S. Olafsson, C. Lancaster, and W. Zhang, Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying,Life Sci. 48, 123–134 (1991).

    Article  PubMed  CAS  Google Scholar 

  4. A. Uehara, T. Okumura, C. Sekiya, K. Okamura, Y. Takasugi, and M. Namiki, Interleukin-1 inhibits the secretion of gastric acid in rats: possible involvement of prostaglandin,Biochem. Biophys. Res. Commun. 162, 1578–1584 (1989).

    Article  PubMed  CAS  Google Scholar 

  5. W. Mertz, Chromium occurrence and function in biological systems,Physiol. Rev. 49, 163–239 (1969).

    PubMed  CAS  Google Scholar 

  6. S. M. Kamath, B. J. Stoecker, M. L. Davis-Whitenack, M. M. Smith, B. O. Adeleye, and S. Sangiah, Absorption, retention and urinary excretion of chromium-51 in rats pretreated with indomethacin and dosed with dimethylprostaglandin E2, misoprostol or prostacyclin,J. Nutr. 127, 478–482 (1997).

    PubMed  CAS  Google Scholar 

  7. R. J. Cousins, Absorption, transport and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin,Physiol. Rev. 65, 238–309 (1985).

    PubMed  CAS  Google Scholar 

  8. R. J. Cousins and A. S. Leinart, Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin 1,FASEB J. 2, 2884–2890 (1988).

    PubMed  CAS  Google Scholar 

  9. R. F. Kampschmidt, H. F. Upchurch, C. L. Eddington, and L. A. Pulliam, Multiple biological activities of a partially purified leukocytic endogenous mediator,Am. J. Physiol. 224, 530–533 (1973).

    PubMed  CAS  Google Scholar 

  10. L. L. Hopkins, Jr. and K. Schwarz, Chromium (III) binding to serum proteins, specifically siderophilin,Biochim. Biophys. Acta 90, 484–491 (1964).

    PubMed  CAS  Google Scholar 

  11. W. Mertz and E. E. Roginski, Effects of chromium(III) supplementation on growth and survival under stress in rats fed low protein diets,J. Nutr. 97, 531–536 (1969).

    PubMed  CAS  Google Scholar 

  12. J. S. Borel, T. C. Majerus, M. M. Polansky, P. B. Moser, and R. A. Anderson, Chromium intake and urinary chromium excretion of trauma patients,Biol. Trace Element Res. 6, 317–326 (1984).

    Article  Google Scholar 

  13. W. Mertz, Chromium in human nutrition: a review,J. Nutr. 123, 626–633 (1993).

    PubMed  CAS  Google Scholar 

  14. R. A. Anderson, Chromium, inTrace Elements in Human and Animal Nutrition, W. Mertz, ed., Academic, New York, pp. 225–244 (1987).

    Google Scholar 

  15. A. del Rey and H. Besedovsky, Interleukin 1 affects glucose homeostasis,Am. J. Physiol. 253, 794–798 (1987).

    Google Scholar 

  16. J. E. Harkness and J. E. Wagner, The rat, inThe Biology and Medicine of Rabbits and Rodents, 2nd ed., Lea and Febiger, Philadelphia, pp. 43–50 (1983).

    Google Scholar 

  17. SAS Institute Inc.,SAS/STAT User’s Guide, Version 6, SAS Institute, Cary, NC (1996).

    Google Scholar 

  18. R. A. Anderson and A. S. Kozlovsky, Chromium intake, absorption and excretion of subjects consuming self-selected diets,Am. J. Clin. Nutr. 41, 1177–1183 (1985).

    PubMed  CAS  Google Scholar 

  19. M. L. Davis, C. D. Seaborn, and B. J. Stoecker, Effects of over-the-counter drugs on51chromium retention and urinary excretion in rats,Nutr. Res. 15, 201–210 (1995).

    Article  CAS  Google Scholar 

  20. M. L. Davis, M. T. Spicer, B. J. Stoecker, and S. Sangiah, Alteration of51Cr absorption and retention by drugs that affect prostaglandins [Abstract],FASEB J. 6, A1951 (1992).

    Google Scholar 

  21. K. G. Mugridge, M. Perretti, J. L. Wallace, and L. Parente, Possible factors involved in the protective effects of interleukin-1 in aspirin and indomethacin-induced gastric damage, inSide Effects of Anti-inflammatory Drugs, K. D. Rainsford and G. P. Velo, eds., Kluwer, Dordrecht, pp. 135–144 (1992).

    Google Scholar 

  22. C. River, W. Vale, and M. Brown, In the rat, interleukin-1α and Β stimulate adrenocorticotropin and catecholamine release,Endocrinology 125, 3096–3102 (1989).

    Article  Google Scholar 

  23. C. D. Seaborn, N. Z. Cheng, B. Adeleye, F. Owens, and B. J. Stoecker, Chromium and chronic ascorbic acid depletion effects on tissue ascorbate, manganese and14C retention from14C-ascorbate in guinea pigs,Biol. Trace Element Res. 41, 279–294 (1994).

    CAS  Google Scholar 

  24. C. D. Seaborn and B. J. Stoecker, Effects of ascorbic acid depletion and chromium status on retention and urinary excretion of51chromium,Nutr. Res. 12, 1229–1234 (1992).

    Article  CAS  Google Scholar 

  25. N. E. Hubbard and K. L. Erickson, Role of 5′-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function.Cell Immunol. 160, 115–122 (1995).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nutritional Sciences, Oklahoma State University, 74078, Stillwater, OK

    Melissa L. Davis-Whitenack, Bernice Adeleye & Barbara J. Stoecker

Authors
  1. Melissa L. Davis-Whitenack
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bernice Adeleye
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Barbara J. Stoecker
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Davis-Whitenack, M.L., Adeleye, B. & Stoecker, B.J. Interleukin-1α-induced changes in chromium-51 absorption, tissue retention, and urinary excretion in rats. Biol Trace Elem Res 68, 175–180 (1999). https://doi.org/10.1007/BF02784405

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02784405

Index Entries

Search

Navigation