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Potential carcinogenicity of some transition metal ions

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Abstract

Potential carcinogenicity of some transition metal ions was tested using a direct-current polarography method. The measurements were based on the reduction of tested compounds in an anhydrous solution using α-lipoic acid as the detection compound. The potential carcinogenicity was expressed in terms of the parameter tg α, which is known to directly correlate with the carcinogenicity of tested compounds. For the metal ions tested, tg α was found to decrease in the following sequence: Fe(III) > Pb(II) > V(IV) > Fe(II) > Mn(II) > Cu(II). Zero values of tg α were found for Cd(II) and Mn(III).

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Authors and Affiliations

  1. Cancer Research Institute, Vlárska 7, Bratislava, Slovakia

    I. Dovinová & A. Vachálková

  2. Faculty of Pharmacy, Kuwait University, 13110, Safat, Kuwait

    L. Novotný

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  1. I. Dovinová
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  2. A. Vachálková
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  3. L. Novotný
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Dovinová, I., Vachálková, A. & Novotný, L. Potential carcinogenicity of some transition metal ions. Biol Trace Elem Res 67, 63–73 (1999). https://doi.org/10.1007/BF02784276

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  • DOI: https://doi.org/10.1007/BF02784276

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