Abstract
Plasma chromium levels were determined in 243 healthy subjects. The study group consisted of 134 men and 109 women, ages 19–71 yr, all residing in Barcelona in northeastern Spain. The study was designed to assess the reference levels for plasma chromium and to investigate its relationships to age and sex. The assays were performed by means of a graphite-furnace atomic absorption spectrometer. The mean plasma chromium concentration was 3.01 ±1.45 nmol/L, ranging from 0.6 to 6 nmol/L. The upper reference values in the 0.95 percentile for this population was 5 nmol/L. No significant differences were observed with respect to the subjects’ sex.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
B. W. Morris, A. Blumsohn, S. MacNei, and T. A. Gray, The trace element chromiuma role in glucose homeostasis,Am. J. Clin. Nutr. 55(5), 989–981 (1992).
R. A. Anderson, Chromium, glucose tolerance, and diabetes,Biol. Trace Element Res. 32, 19–24 (1992).
S. A. Katz and H. Salem, The toxicology of chromium with respect to its chemical speciation: a review,J. Appl. Toxicol. 13(3), 217–224 (1993).
S. I. Vishniakov, S. A. Levantovskii, and G. F. Ryzhkova, The biological action of chromium in relation to its valency,Biol. Nauki (Byelarus)9, 105–108 (1992).
F. Baruthio, Toxic effects of chromium and its compounds,Biol. Trace Element Res. 32, 145–153 (1992).
M. Torra, J. To-Figueras, M. Brunet, M. Rodamilans, and J. Corbella, Total and metallothionein-bound cadmium in the liver and the kidney of a population in Barcelona (Spain),Bull. Environ. Contamin. Toxicol. 53(4), 509–515 (1994).
M. Rodamilans, M. Torra, J. To-Figueras, J. Corbella, B. López, C. Sánche, et al., Effect of the reduction of petrol lead on blood lead levels of the population of Barcelona, (Spain),Bull. Environ. Contamin. Toxicol. 56(5), 717–721 (1996).
M. Torra. M. Rodamilans, F. Montera, C. Farré, and J. Corbella, Estudio de la exposición actual al plomo en la población de Barcelona: evolución cronológica entre 1984 y 1995,Med. Clin. 108, 601–603 (1997).
J. M. Llobet, S. Granero, A. Torres, M. Schuhmacher, and J. L. Domingo, Biological monitoring of environmental pollution and exposure to metal in Tarragona, Spain. III. Blood levels,Trace Element Electrol. 15(2), 76–80 (1998).
P. Saavedra, F. L. Arrieta, A. Jorge, C. Mateos, M. C. Martinez-Para, M. V. Aguilar, et al., Effect of diabetes mellitus non-insulin-dependent on chromium content in plasma and on its urinary excretion,Metal Ions Biol. Med. 4, 535–537 (1996).
P. Chappuis, J. Poupon, J. F. Deschamps, P. J. Guillausseau, and F. Rousselet, Physiological chromium determination in serum by Zeeman graphite furnace atomic absorption spectrometry. A serious challenge,Biol. Trace Element Res. 32, 85–91 (1992).
S. Davies, J. McLaren Howard, A. Hunnisett, and M. Howard. Age-related decreases in chromium levels in 51665 hair, sweat, and serum samples from 40872 patients-implications for the prevention of cardiovascular disease and type II diabetes mellitus,Metabolism 46(5), 469–473 (1997).
W. Mertz, Confirmation: chromium levels in serum, hair and sweat decline with age,Nutr. Rev. 55(10), 373–375 (1997).
D. J. Paustenbach, J. M. Panko, M. M. Fredrick, B. L. Finley, and D. M. Proctor, Urinary chromium as a biological marker of environmental exposure: what are the limitations?Regul. Toxicol. Pharmacol. 26 (1Pt2): S23-S34 (1997).
D. Brune, A. Aitio, G. Nordberg, O. Vesterberg, and L. Gerhardsson, Normal concentrations of chromium in serum and urine -a TRACY project,Scand. J. Work Environ. Health 19, 39–44 (1993).
A. S. Abraham, B. A. Brooks, and U. Eylath, The effects of chromium supplementation on serum glucose and lipids in patients with and without non-insulin-dependent diabetes,Metabolism 41(7), 768–771 (1992).
J. Versieck, L. Vanballenberghe, A. De Kesel, and J. Iloste, Certification of a secondgeneration biological reference material (freeze-dried human serum) for trace element determination,Anal. Chim. Acta 204, 63–75 (1988).
V. A. Granadillo, L. Parra de Machado, and R. A. Romero, Determination of total chromium in whole blood, blood components, bone, and urine by fast furnace program electrothermal atomization AAS and using neither analyte isoformation nor background correction,Anal. Chem. 66(21), 3624–3631 (1994).
J. M. Christensen, E. Holst, J. P. Bonde, and L. Knudsen, Determination of chromium in blood and serum: evaluation of quality control procedures and estimation of reference values in Danish subjects,Sci. Total Environ. 123(1), 11–25 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Torra, M., Rodamilans, M., Corbella, J. et al. Blood chromium determination in assessing reference values in an unexposed mediterranean population. Biol Trace Elem Res 70, 183–189 (1999). https://doi.org/10.1007/BF02783859
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02783859