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Toxic effects of chromium and its compounds

  • Part 1: Chromium
  • Section 2: Chromium in Human Diseases
  • Published:
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Abstract

Chromium was discovered in 1797 by Vauquelin. Numerous industrial applications raised chromium to a very important economic element. At the same time, with the development of its uses, the adverse effects of chromium compounds in human health were being defined. Trivalent chromium is an essential trace element in humans and in animals. Chromium as pure metal has no adverse effect. Little toxic effect is attributed to trivalent chromium when present in very large quantities. Both acute and chronic toxicity of chromium are mainly caused by hexavalent compounds. The most important toxic effects, after contact, inhalation, or ingestion of hexavalent chromium compounds are the following: dermatitis, allergic and eczematous skin reactions, skin and mucous membrane ulcerations, perforation of the nasal septum, allergic asthmatic reactions, bronchial carcinomas, gastro-enteritis, hepatocellular deficiency, and renal oligo anuric deficiency. Prevention of occupational risks, biological monitoring of workers, and treatment of poisoning are also reported.

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References

  1. K. Schwarz and W. Mertz,Arch. Biochem. Biophys. 72, 515 (1957).

    Article  PubMed  CAS  Google Scholar 

  2. H. Brieger,Z. Exp. Pathol. Ther. 21, 393 (1920).

    Article  CAS  Google Scholar 

  3. J.M. Haguenoer and D. Furon,Toxicologie et Hygiène industrielles, tome 2, Technique et Documentation, Paris, 1982, p. 275.

    Google Scholar 

  4. S. Langard and T. Norseth,Handbook on the Toxicology of Metals, 2d ed. L. Friberg, G.F. Nordberg, and V. Voui, eds., Elsevier Science Publishers, B.V., 1986, p. 185.

  5. L. Polak,Chromium: Metabolism and Toxicity, D. Burrows, ed., CRC Press., Boca Raton, FL 1983, p. 5.

    Google Scholar 

  6. D. Burrows,Chromium: Metabolism and Toxicity, D. Burrows, ed., CRC Press, Boca Raton, FL, 1983, p. 137.

    Google Scholar 

  7. WHO,Chromium, Environmental Health Criteria 61, World Health Organization, Geneva, 1988, pp. 1–197.

    Google Scholar 

  8. IARC,Monograph on the Chromium and Chromium Compounds, vol. 23, International Agency for Research on Cancer, Lyon, 1980, p. 205.

    Google Scholar 

  9. R.M. Stern,Arch. Environ. Health 38, 148 (1983).

    PubMed  CAS  Google Scholar 

  10. T. Norseth,Br. J. Ind. Med. 43, 649 (1986).

    PubMed  CAS  Google Scholar 

  11. S. Langard,Am. J. Ind. Med. 17, 189 (1990).

    Article  PubMed  CAS  Google Scholar 

  12. A. Johansson, A. Wiernick, C. Jarstrand, and P. Camner,Environ. Res. 39, 372 (1986).

    Article  PubMed  CAS  Google Scholar 

  13. D. Persson, R. Osterberg, and G. Bjursell,Acta Pharmacol. Toxicol. 59, suppl. VII, 260 (1986).

    CAS  Google Scholar 

  14. A. Leonard and R.R. Lauwerys,Mutat. Res. 76, 227 (1980).

    PubMed  CAS  Google Scholar 

  15. A.G. Levis and F. Majone,Br. J. Cancer 44, 219 (1981).

    PubMed  CAS  Google Scholar 

  16. E. Nieboer and S.L. Show,Chromium in the Natural and Human Environment, J.O. Nriagu and E., Nieboer, eds., John Wiley and Sons, New York, 1988, p. 399.

    Google Scholar 

  17. Z. Elias, O. Poirot, O. Schneider, M.C. Danière, F. Terzetti, J.C. Guedenet, and C. Cavelier,Mutat. Res. 169, 159 (1986).

    Article  PubMed  CAS  Google Scholar 

  18. Z. Elias, O. Poirot, H. Pezerat, H. Suquet, O. Schneider, M.C. Danière, F. Terzetti, F. Baruthio, M. Fournier, and C. Cavelier,Carcinogenesis,10, 2043. (1989).

    Article  PubMed  CAS  Google Scholar 

  19. A.B. Bigaliev, M.N. Turebaev, R.K. Bigalieva, and M.S. Elemesova,Genetika,13, 545 (1977).

    PubMed  CAS  Google Scholar 

  20. T. Nagaya, N. Ishikawa, and H. Hata,Br. J. Ind. Med. 46, 48 (1989).

    PubMed  CAS  Google Scholar 

  21. R. Kishi, T. Tarumi, E. Uchino, and H. Miyake,Am. J. Ind. Med. 11, 67 (1987).

    Article  PubMed  CAS  Google Scholar 

  22. N.A. Dalager, T.J. Mason, J.F. Fraumein, R. Hoover, and W.W. Payne,J. Occup. Med. 22, 25 (1980).

    Article  PubMed  CAS  Google Scholar 

  23. A. Borghetti, A. Mutti, and A. Cavatorta,Med. Lav. 68, 355 (1977).

    PubMed  CAS  Google Scholar 

  24. D.R. Williams and B.W. Halstead,Clin. Toxicol. 19, 1081 (1982).

    Article  CAS  Google Scholar 

  25. S.K. Tandon and J.S. Gaur,Clin. Toxicol. 11, 257 (1977).

    PubMed  CAS  Google Scholar 

  26. J. Angerer, W. Amin, R. Heinrich-Ramm, D. Szadkowski, and G. Lehnert,Int. Arch. Occup. Environ. Health 59, 503 (1987).

    Article  PubMed  CAS  Google Scholar 

  27. A. Mutti, A. Cavatorta, C. Pedroni, A. Borghi, C. Giaroli, and I. Franchini,Int. Arch. Occup. Environ. Health 43, 123 (1979).

    Article  PubMed  CAS  Google Scholar 

  28. A. Tossavainen, M. Nurminen, P. Mutanen, and S. Tola,Br. J. Ind. Med. 37, 285 (1980).

    PubMed  CAS  Google Scholar 

  29. I. Franchini, A. Mutti, A. Cavatorta, A. Corradi, A. Cosi, G. Olivetti and A. Borghetti,Contr. Nephrol. 10, 98 (1978).

    CAS  Google Scholar 

  30. H. Welinder, M. Littorin, B. Gullberg and S. Skerfving,Scand. J. Work Environ. Health 9, 397 (1983).

    PubMed  CAS  Google Scholar 

  31. J. Lewalter, U. Korallus, C. Harzdorf, and H. Weidemann,Int. Arch. Occup. Environ. Health 55, 305 (1985).

    Article  PubMed  CAS  Google Scholar 

  32. H.J. Wiegand, H. Ottenwalder, and H.M. Bolt,Arbeitsmed. Sozialmed. Präventivmed. 20, 1 (1985).

    Google Scholar 

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Authors and Affiliations

  1. Sferete, BP 27-54501, Vandoeuvre, Cedex, France

    François Baruthio

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  1. François Baruthio
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Baruthio, F. Toxic effects of chromium and its compounds. Biol Trace Elem Res 32, 145–153 (1992). https://doi.org/10.1007/BF02784599

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  • DOI: https://doi.org/10.1007/BF02784599

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