Abstract
Time-response effects of experimental surgery on zinc (Zn) and metallothionein (MT) homeostasis were investigated in female rats up to 24 h. Hepatic Zn content increased at 20 and 24 h postsurgery, whereas serum Zn levels decreased. Hepatic MT increased significantly by 9 h postsurgery and peaked at up to twofold of control at 12 h after surgery. Following the peak at 12 h, hepatic MT content decreased with time but did not reach control levels at the end of this study. When MT isoforms were evaluated, MT-II levels were elevated to the highest extent by 12 h after surgery, whereas MT-I levels started to decrease after 3 h postsurgery but then increased by 20 h. The early increases in MT content are probably mediated by nonmetallic mediators released during the postsurgical inflammatory process, favoring the plasma/tissue mobilization of Zn. This process might be part of the overall mechanisms occurring in the inflammation.
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References
B. L. Vallee and D. S. Auld,FEBS Lett. 257, 138 (1989).
B. L. Vallee and D. S. Auld,Biochemistry 29, 5647 (1990).
F. Y. H. Wu and C. W. Wu,Ann. Rev. Nutr. 7, 251 (1987).
B. L. Vallee and K. H. Falchuck,Physiol. Rev. 73, 79 (1993).
M. C. Powanda,Am. J. Nutr. 30, 1254 (1977).
U. Srinivas, J. H. Braconier, B. Jeppsson, M. Abdulla, B. Akesson, and P. A. Ockerman,Scand. J. Clin. Invest. 48, 495 (1988).
M. C. Powanda, G. L. Cockerell, and R. S. Pekarek,Am. J. Physiol. 255, 399 (1973).
A. M. Rofe, J. C. Phylcox, D. R. Haynes, M. W. Whitehouse, and P. Coyle,Biol. Trace Element Res. 34, 237 (1992).
D. Breuile, F. Rose, M. Arnal, M. Melin, and C. Obled,Clin. Sci. 86, 663 (1994).
A. Shenkin,Nutrition 11, 100 (1995).
J. C. Phylcox, P. Coyle, A. Michalska, K. H. Choo, and A. M. Rofe,Biochem. J. 308, 543 (1995).
F. O. Brady and B. Helvig,Am. J. Physiol. 247, E318 (1984).
R. A. DiSilvestro and R. J. Cousins,Life Sci. 35, 2113 (1984).
D. H. Hamer,Ann. Rev. Biochem. 55, 913 (1986).
K. L. Huber and R. J. Cousins,J. Nutr. 118, 1570 (1988).
J. J. Schroeder and R. J. Cousins,Proc. Natl. Acad. Sci. USA 87, 3137 (1990).
P. Coyle, J. C. Phylcox, and A. M. Rofe,J. Nutr. 123, 1464 (1993).
P. Coyle, J. C. Phylcox, and A. M. Rofe,Inflamm. Res. 44, 475 (1995).
A. Okada, Y. Takagi, R. Nezu, and S. Lee,Jpn. J. Surg. 20, 635 (1990).
F. O. Brady,Life Sci. 28, 1647 (1981).
K. Sakamoto, H. Arakawa, S. Mita, T. Ishiko, S. Ikei, H. Egami, et al.,Citokine 6, 181 (1994).
R. B. Mateo, J. S. Reichner, and J. E. Albina,Am. J. Physiol. 266, R1840 (1994).
H. Ueo, H. Inoue, M. Honda, I. Uchida, M. Nishimura, S. Arinaga, et al.,J. Am. Coll. Surg. 179, 326 (1994).
S. Meret and R. Henkin,Clin. Chem. 17, 369 (1971).
D. L. Eaton and B. F. Toal,Toxicol. Appl. Pharmacol. 66, 134 (1982).
S. Onosaka and M. G. Cherian,Toxicol. Appl. Pharmacol. 63, 270 (1982).
L. Y. Lin and C. C. McCormick,Biol. Trace Element Res. 11, 147 (1986).
J. S. Garvey, R. J. Vander-Mallie, and Ch. C. Chang,Meth. Enzymol. 84, 121 (1992).
N. T. J. Bailey,Statistical Methods in Biology, The English Universities Press, London, 1975, p. 43 (1975).
D. M. Steel and A. S. Whithead,Immun. Today 15, 81 (1994).
M. Werner,Clin. Chim. Acta 25, 299 (1969).
F. O. Brady,Trends Biochem. Sci. 7, 143 (1982).
J. H. R. KÄgi and A. SchÄffer, Perspectives in Biochemistry, vol. I, H. Neurath, ed.,Am. Chem. Soc, Washington, DC, pp. 46–52 (1989).
C. D. Klaassen and L. D. Lehman-McKeeman,Biol. Trace Element Res. 21, 119 (1989).
M. L. Failla and R. J. Cousins,Biochim. Biophys. Acta. 543, 293 (1978).
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Brambila, E., Muñoz-Sánchez, J.L., Albores, A. et al. Early effects of surgery on zinc and metallothionein levels in female rats. Biol Trace Elem Res 70, 173–182 (1999). https://doi.org/10.1007/BF02783858
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DOI: https://doi.org/10.1007/BF02783858