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Intracellular distribution of hepatic copper in macular mutant mice

An animal model of Menkes' kinky-hair disease

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Abstract

To evaluate the role of lysosomes in copper-mediated hepatocellular injury, copper was administered, sc, to both normal and macular mutant mice at doses of 4.5, 9.0, and 18 mg Cu/kg, and the subcellular distribution of copper has been investigated in the liver of normal and mutant mice 24h after injection. The amount of copper in all fractions of copper-treated mutant mice was markedly lower than those in copper-treated normal mice, with the exception of microsomal fraction. However, there were no distinct differences in the proportion of copper in subcellular fractions between normal and mutant mice.

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Authors and Affiliations

  1. Department of Environmental and Occupational Health, Kochi Medical School, 783, Kochi, Japan

    Noriyuki Shiraishi, Tetsuya Taguchi & Hideo Kinebuchi

Authors
  1. Noriyuki Shiraishi
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  2. Tetsuya Taguchi
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  3. Hideo Kinebuchi
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Shiraishi, N., Taguchi, T. & Kinebuchi, H. Intracellular distribution of hepatic copper in macular mutant mice. Biol Trace Elem Res 37, 179–186 (1993). https://doi.org/10.1007/BF02783793

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  • DOI: https://doi.org/10.1007/BF02783793

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