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Competition of Mn2+ and Zn2+ with59Fe2+ and59Fe3+ for the plasma membrane receptors from lactating mouse mammary gland

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Abstract

Nonlabeled MnCl2 and ZnSO4 compete with59Fe2+-ascorbate and59Fe 3+2 O3 for transport binding sites situated on the plasma membranes of lactating mouse mammary gland cells. The binding was found to be a process reaching saturation.

The heterologous competition used here ruled out the participation of transferrin and to propose that Fe, Mn, and Zn are transported from blood to milk by a mechanism involving one receptor during lactation. Further experiments are necessary to establish the details of the transport mechanism.

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Authors and Affiliations

  1. Department of Biochemistry, Research Medico-Biological Institute, Medical Academy, 2 Zdrave Str., 1431, Sofia, Bulgaria

    Dimiter A. Moutafchiev & Ljuben M. Sirakov

Authors
  1. Dimiter A. Moutafchiev
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  2. Ljuben M. Sirakov
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Moutafchiev, D.A., Sirakov, L.M. Competition of Mn2+ and Zn2+ with59Fe2+ and59Fe3+ for the plasma membrane receptors from lactating mouse mammary gland. Biol Trace Elem Res 35, 203–211 (1992). https://doi.org/10.1007/BF02783766

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  • DOI: https://doi.org/10.1007/BF02783766

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