Summary
The effects of dopamine (DA) on the prostaglandin (PG) E2 content of rat gastric mucosa was investigated. There was a 17.5% increase in gastric mucosal blood flow (BF) after administration of DA (5 μ/kg/min iv). After pretreatment with fusaric acid (FA), an antagonist of dopamine ß hydroxylase, DA increased BF by 27.8%. The PGE2 content in DA and DA + FA groups increased at rates of 45.8% and 42.4%, respectively. The PGE2 content in gastric mucosa after incubation following Basso’s method, increased in the DA, DA + FA and noradrenaline (NA) groups to 3.32±0.40 μg/g, 3.30±0.39 μg/g and 3.37±0.42 μg/g respectively. It is concluded that there are no differences in PGE2 content among the DA, DA + FA and NA groups. The mechanism by which PGE2 content increases after administration of DA is the direct action of DA and/or increasing BF. It is suspected that DA directly affects PGE2 synthesis, however the possibility that DA is metabolized to NA, which secondarily results in increased PGE2 synthesis, cannot be excluded.
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Nagahata, Y., Urakawa, T. & Saitoh, Y. Effect of dopamine on prostaglandin E2 content in gastric mucosa. Gastroenterol Jpn 25, 681–684 (1990). https://doi.org/10.1007/BF02779180
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DOI: https://doi.org/10.1007/BF02779180