Abstract
In this study, experimental hyperthyroidism was established and used to investigate possible alterations in the calcium (Ca), magnesium (Mg), and zinc (Zn) homeostasis by assessing their concentrations in plasma and erythrocytes.
In the L-thyroxine-induced hyperthyroidism condition, the experimental animals show a significant decrease in erythrocyte Ca, Mg, and Zn concentrations, and a significant decrease in plasma Mg concentration. Significant positive correlations were found for Mg and Zn both in plasma and in erythrocytes.
The results suggest that the homeostasis of Ca, Mg, and Zn is altered during experimental hyperthyroidism.
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K. D. Burman, J. M. Monchik, J. M. Earl, and L. Wartofsky, Ionized and total serum calcium and parathyroid hormone in hyperthyroidism,Ann. Intern. Med. 84, 668–671 (1976).
Y. Shibutani, T. Yokota, S. Ijima, A. Fujioka, S. Katsuno, and K. Sakamoto, Plasma and erythrocyte magnesium concentrations in thyroid disease: relation to thyroid function and the duration of illness.Jpn. J. Med. 28, 496–502 (1989).
K. Aihara, Y. Nishi, S. Hatano, M. Kihara, K. Yoshimitsu, and N. Takeichi, Zinc, copper, manganese and selenium metabolism in thyroid disease,Am. J. Clin. Nutr. 40, 26–35 (1984).
H. C. Ford, M. J. Crooke, and C. E. Murphy, Disturbances of calcium and magnesium metabolism occur in most hyperthyroid patients,Clin. Biochem. 22, 373–376 (1989).
E. Dolev, P. A. Deuster, B. Solomon, U. H. Trostmann, L. Wartofsky and K. D. Burman, Alterations in magnesium and zinc metabolism in thyroid disease,Metabolism 37, 61–67 (1988).
N. Dursun, M. Karatay, S. Akar, and G. Biberoglu, The influence of hyperthyroidism on zinc distribution in adult rats,Jpn. J. Physiol. 45, 197–202 (1995).
A. O. Olukoga, R. T. Erasmus, and H. O. Adewoye, Erythrocyte and plasma magnesium status in Nigerians with diabetes mellitus,Ann. Clin. Biochem. 26, 74–77 (1989).
N. M. Shevstova, A. Kozlov, and V. V. Novitskii, Mechanism of hematopoietic disorders in primary experimental hypothyroidism,Patol. Fiziol. Exsp. Ter. 1, 14–16 (1994).
K. C. Das, M. Mukherjee, T. K. Sarkar, R. J. Dash, and G. K. Rastogi, Erythropoiesis and erythropoietin in hypo- and hyperthyroidism,J. Clin. Endocrinol. Metab. 40, 211–220 (1975).
J. G. Daly, R. M. Greenwood, and R. L. Himsworth, Serum calcium concentration in hyperthyroidism at diagnosis and after treatment,Clin. Endocrinol. 19, 397–404 (1983).
R. K. Rude, Magnesium metabolism and deficiency,Endocrinol. Metabol. Clin. N. Am. 22, 377–395 (1993).
K. Yoshida, Y. Kiso, T. Watanabe, K. Kaise, N. Kaise, and Y. Hagaki, Erythrocyte zinc in hyperthyroidism: reflection of integrated thyroid hormone levels over the previous few months,Metabolism 39, 182–186 (1990).
K. Yoshida, Y. Kiso, T. Watanabe, K. Kaise, N. Kaise, and H. Fukazawa, Clinical utility of red blood cell carbonic anhydrase I and zinc concentrations in patients with thyroid diseases,Metabolism 40, 1048–1051 (1991).
N. Taniguchi, N. Ishikawa, and T. Kondo, Inhibitory effect of thyroxine on carbonic anydrase B isozyme biosynthesis in rabbit reticulocyte lysates,Biochem. Biophys. Res. Commun. 85, 952–958 (1978).
Y. Nishi, R. Kawate, and T. Usui, Zinc metabolism in thyroid disease,Postgrad. Med. J. 56, 833–837 (1980).
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Simsek, G., Andican, G., Ünal, E. et al. Calcium, magnesium, and zinc status in experimental hyperthyroidism. Biol Trace Elem Res 57, 131–137 (1997). https://doi.org/10.1007/BF02778196
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DOI: https://doi.org/10.1007/BF02778196