Skip to main content

Advertisement

SpringerLink
Log in

Investigation of the hepatic excretion mechanism of indocyanine green in patients with liver disease

  • Original Article
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

The purpose of the present paper is to clarify the disturbance of the indocyanine green (ICG) uptakeexcretion mechanism in patients with liver disease. The following parameters were used to indicate the disappearance rate of various dyes from plasma; K for ICG, KAU for198Au colloid and KRB for131I-rose bengal. ICG was administered intravenously using three different continuous infusion rates on all patients. The maximum rate of biliary excretion (Tm) as well as the relative hepatic storage capacity (S) were determined. Tm and S definitely decreased in cases with liver cirrhosis. Tm had no relationship to the degree of liver damage, but S fell in proportion to its dysfunction. Kau and KRB significantly decreased in cases of liver cirrhosis, while chronic aggressive hepatitis revealed a marked decrease of KRB without an equivalent decrease of KAU. The correlation coefficient between K and S was definitely higher than that between K and Tm, and K was more closely correlated with KRB than KAU-From these results, it was reasonable to presume that K was more influenced by the hepatic uptake and storage than by the excretion of ICG in the bile, and indicated the capacity of the liver to handle dyes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Fox, I.J. and Wood, E.H.: Indocyanine green; physical and physiologic properties, Proceedings of the staff Meetings of the Mayo Clinic, 35: 432, 1960.

    Google Scholar 

  2. Caeser, J., Shaldon, S., Chiandussi, L., Cuevara, L. and Sherlock, S.: The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. Clin. Sci., 21: 43, 1961.

    Google Scholar 

  3. Cherrick, G.R., Stein, S.W., Leevy, C.M. and Davidson, C.S.: Indocyanine green: Observations on its physical properties, plasma decay, and hepatic extraction. J. Clin. Invest., 39: 592, 1960.

    PubMed  CAS  Google Scholar 

  4. Hunton, D.B., Bollman, J.L. and Hoffman, H.N.: Studies of hepatic function with indocyanine green. Gastroenterology, 39: 713, 1960.

    PubMed  CAS  Google Scholar 

  5. Hunton, D.B., Bollman, J.L. and Hoffman, H.N.: The plasma removal of indocyanine green and sulfobromophthalein. J. Clin. Invest., 40: 1648, 1961.

    PubMed  CAS  Google Scholar 

  6. Leevy, CM., Stein, S.W., Cherrick, G.R. and Davidson, C.S.: Indocyanine green clearance. A test of liver excretory function. Clin. Res., 7: 290, 1959.

    Google Scholar 

  7. Reemtsma, K., Hottinger, G.C., DeGraff, A.C. and Creech, O.: Studies of hepatic function and blood flow using indocyanine green. Clin. Res., 8: 77, 1960.

    Google Scholar 

  8. Reemtsma, K., Hottinger, G.C., DeGraff, A.C. and Creech, O.: The estimation of hepatic blood flow using indocyanine green. Surg. Gyn. Obst., 110: 353, 1960.

    Google Scholar 

  9. Wheeler, H.E., Cranston, W.I. and Meltzer, J.L: Hepatic uptake and biliary excretion of indocyanine green in the dog. Proc. Soc. Exp. Biol. Med., 99: 11, 1958.

    PubMed  CAS  Google Scholar 

  10. Wiegand, B.D., Ketterer, S.G. and Rapaport, E.: The use of indocyanine green for the evaluation o. hepatic function and blood flow in man, Amer. J. Dig. Dis., 5: 427, 1960.

    Article  PubMed  CAS  Google Scholar 

  11. Nakagawa, S., Takebayashi, J., Hoshida, M., Iwashita, T., Kojo, Y. and Hagiwara, K.: Clinical studies on indocyanine green (ICG) test. J. Kumamoto Med. Soc, 46: 60, 1972.

    Google Scholar 

  12. Nambu, M.: Hepatic clearance of indocyanine green in liver diseases. Jap. J. Gastroenterology, 63: 777, 1966.

    Google Scholar 

  13. Kuchiba, K. and Kondo, T.: Studies on familially observed delay in clearance of plasma indocyanine green, Part I: Evidence for delayed plasma clearance of ICG without liver disease in a consanguineous Japanese kindred. Acta Hepatologica Japo., 15: 223, 1974.

    Google Scholar 

  14. Nambu, M. and Namihisa, T.: Constitutional ICG excretory defect—Investigation of cases reported until December, 1974., Jap. J. Gastroenterology, 72: 1002, 1975.

    Google Scholar 

  15. Wheeler, H.O., Meltzer, J.I. and Bradley, S.E.: Biliary transport and hepatic storage of sulfobromophthalein sodium in the unanesthized dog, in normal man, and in patients with hepatic disease. J. Clin. Invest., 39: 1131, 1960.

    Article  PubMed  CAS  Google Scholar 

  16. Kanai, T.: Compartmental analysis of transport and tolerance test of indocyanine green in normal subjects and in patients with hepatic dysfunction. Jap. J. Gastroenterology, 69: 228, 1972.

    CAS  Google Scholar 

  17. Preisig, R., Williams, R., Sweeting, J. and Bradley, S.E.: Changes in sulfobromophthalein transport and storage by the liver during viral hepatitis in man. Amer. J. Med., 40: 170, 1966.

    Article  PubMed  CAS  Google Scholar 

  18. Raymond, G.D. and Galambos, J.T.: Hepatic storage and excretion of bilirubin in man. Amer. J. Gastroent., 55: 135, 1971.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Third Department of Internal Medicine, Kumamoto University Medical School, 1-1 Honjo 1-chome, 860, Kumamoto City, Japan

    Shoso Nakagawa M.D., Kenji Nagata M.D., Kazufumi Araki M.D. & Hideo Nagashima M.D.

Authors
  1. Shoso Nakagawa M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenji Nagata M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kazufumi Araki M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hideo Nagashima M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakagawa, S., Nagata, K., Araki, K. et al. Investigation of the hepatic excretion mechanism of indocyanine green in patients with liver disease. Gastroenterol Jpn 11, 237–245 (1976). https://doi.org/10.1007/BF02777709

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02777709

Key Words

Search

Navigation