Summary
The diagnostic usefulness of serum amylase isozyme measurement was investigated in 17 cases of definite chronic pancreatitis and 13 cases of suspected chronic pancreatitis, a total of 30 cases.
Six types of serum isoamylase patterns were distinguished according to the character of the two main amylase activities at the fractions of fast-y globulin and pre-γ globulin.
The amylase activity at the fast-γ fraction rises in acute exacerbation, and falls in cases of chronic calcifying pancreatitis and in cases with a marked decrease in pancreatic exocrine function. Especially, a fall in fast-γ amylase activity excellently reflects a decrease in pancreatic enzyme production. The measurement of amylase activity at the fast-γ fraction therefore appears to be a useful method for assessing pancreatic damage. The significance of a frequent rise in pre-γ amylase activity in chronic pancreatitis remains unknown.
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Wakabayashi, A. Serum amylase isozyme changes in chronic pancreatitis and their clincal significance. Gastroenterol Jpn 11, 196–202 (1976). https://doi.org/10.1007/BF02777704
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DOI: https://doi.org/10.1007/BF02777704