Summary
Mucous barrier was searched by the histochemical method of mucopolysaccharides and by the measurement of precipitated mucus of gastric juice. The neutral polysaccharide stored within the surface epithelial cells must be a source of the mucus of the gastric juice. The storage of the polysaccharide was decreased by a long-term stimulation by histamine, and the precipitated mucus volume was also decreased shortly after the stimulation. Therefore, some kind of the stimulation for the gastric secretion must be avoided for prevention of peptic ulcer. The oral administration of the sulfuric polysaccharide extracted from seaweed prevented the occurrence of experimental ulcer. It may be concluded that the exogeneous polysaccharide can take the place of the endogeneous polysaccharide.
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References
Hollander, F.: The two-component mucous barrier. Its activity in protecting the gastroduodenal mucosa against peptic ulceration. Arch. Int. Med., 93: 107–120, 1954.
Glass, G.B.J.: Gastric mucin and its constituents: Physicochemical characteristics, cellular origin, and physiological significance. Gastroenterology, 23: 636–658, 1953.
Spicer, S.S.: Histochemical differentiation of mam-malian mucopolysaccharides. Ann. N.Y. Acad. Sci., 106: 379–387, 1963.
Mowry, R.W.: The special value of methods that color both acidic and vicinal hydroxyl group in the histochemical study of mucins. With revised direc-tions for the colloidal iron stain, the use of alcian blue G8X and their combinations with the periodic acid-schiff reaction. Ann. N.Y. Acad. Sci., 106: 402–423, 1963.
Lambert, R., Martin, F., Andre, C., et al.: Apical localization of glycoproteins in gastric mucous cells. Amer. J. Digest. Dis., 13: 941–951, 1968.
Lillie, R.D.: Histopathologic technic and practical histochemistry. Blackiston, New York, 1954.
Umehara, S.: Development and healing of the gastric ulcer. From a view point of expermental clamping-cortisone and serosa-searing ulcer in rats. Japan, J. Gastroent., 70: 351–358, 1973.
Marcus, M.M.R. et Watt, J.: L’action et la répartition d’un polysaccharide sulfaté (Polysac-charide C16). Au niveau de la muqueuse gastrique. Arch. Mal. Appar. dig., 54: 457–466, 1965.
Bonfils, S., Dubrasquet, M. et Lambling, A.: L’inhibition de la protéolyse peptique par divers polysaccharides. Rev. franc. Etud. clin, biol., 5: 71–74, 1960.
Menguy, R.: Gastric mucus and the gastric mucous barrier. Amer. J. Surg., 117: 806–812, 1969.
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Iida, F. Mucous barrier and peptic ulcer of the stomach. Gastroenterol Jpn 11, 175–181 (1976). https://doi.org/10.1007/BF02777701
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DOI: https://doi.org/10.1007/BF02777701