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Effects of ranitidine on plasma clearance of indocyanine green in patients with liver cirrhosis

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Summary

The effects of ranitidine on plasma clearance of ICG were investigated in 68 cirrhotic patients (9 were positive for HBsAg, 33 were alcoholics and 26 had cryptogenic cirrhosis). The ICG clearance test was performed before and after ranitidine administration.

In 31 patients treated with ranitidine (150 mg perorally), the plasma ICG clearance were 233.6 ± 20.4 m1/min (mean ∓ S.E.) and 239.2 ± 20.5 ml/min before and after ranitidine, respectively. In the 37 treated with intravenous ranitidine 50 mg, the corresponding values were 205.4 ± 17.7 ml/min and 206.4 ± 17.9 ml/min. There was no significant change in the plasma clearance of ICG or the elimination rate constant after ranitidine administration. Even in patients with decompensated liver cirrhosis, no significant change was demonstrated in the plasma ICG clearance after ranitidine.

These results led to the conclusions that ranitidine does not reduce the hepatic blood flow and that it is a safe and useful drug for the treatment of gastrointestinal tract bleeding in patients with liver cirrhosis.

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Authors and Affiliations

  1. First Department of Internal Medicine, School of Medicine, Mie University, 2-174 Edobashi, Tsu, 514, Mie, Japan

    Yoshitane Kosaka M.D. & Yukihiko Tameda M.D.

  2. First Department of Internal Medicine, Yamaguchi University School of Medicine, 755, Ube, Japan

    Kiwamu Okita M.D. & Adayoshi Takemoto M.D.

  3. Iwate Medical University School of Medicine, 020, Morioka, Japan

    Shunichi Sato M.D.

  4. First Department of Mediane, Chiba University School of Medicine, 280, Chiba, Japan

    Kunio Okuda M.D.

  5. First Department of Internal Medicine, The Jikei University School of Medicine, 105, Tokyo, Japan

    Haruo Kameda M.D.

  6. Third Department of Internal Medicine, Osaka City University Medical School, 545, Osaka, Japan

    Sukeo Yamamoto M.D.

  7. First Department of Internal Medicine, Osaka University Medical School, 553, Osaka, Japan

    Takenobu Kamada M.D.

  8. First Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan

    Yasutoshi Muto M.D.

Authors
  1. Yoshitane Kosaka M.D.
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  2. Yukihiko Tameda M.D.
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  3. Kiwamu Okita M.D.
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  4. Adayoshi Takemoto M.D.
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  5. Shunichi Sato M.D.
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  6. Kunio Okuda M.D.
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  7. Haruo Kameda M.D.
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  8. Sukeo Yamamoto M.D.
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  9. Takenobu Kamada M.D.
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  10. Yasutoshi Muto M.D.
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Kosaka, Y., Tameda, Y., Okita, K. et al. Effects of ranitidine on plasma clearance of indocyanine green in patients with liver cirrhosis. Gastroenterol Jpn 22, 737–742 (1987). https://doi.org/10.1007/BF02776747

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  • DOI: https://doi.org/10.1007/BF02776747

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