Summary
Comparative clinical trials were conducted by the double-blind technique in a series of 302 cases of gastric ulcer at fifteen medical institutions in order to investigate the clinical course of peptic ulceration and the effect of pharmacotherapy on it, using N-acetyl-L-glutamine aluminum complex (KW) as test drug and basic aluminum sucrose sulfate (UL) as reference drug as well as an inactive placebo of lactose (PL) with the results as follows:
In 12 weeks of treatment with inactive placebo, a higher cure rates were noted in inpatients than in outpatients, and in patients with ulceration in the corpus ventriculi than in those with ulceration at the angulus. The overall evaluation of therapeutic responses indicated that, both KW and UL were significantly superior in efficacy to placebo in 12 weeks of therapy. These two medicaments displayed different modes of efficacy, possibly reflecting their different mechanisms of pharmacologic action. The efficacy of the medicaments was particularly superior in outpatients and patients with peptic ulceration at the gastric angle both of which showed lower rates of response to placebo.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Shiozaki, K. and Hashimoto, M.: Physicochemical properties of N-acetyl-L-glutamine aluminum complex. Yakuzaigaku (Jap.), 32: 56–60, 1972.
2)Takagi, K., Takeuchi, K., Morita, A. and Okabe, S.: Effects of an antiulcer agent, N-acetyl-L-glutamine aluminum complex (KW) on the duodenal and gastric ulcer models in the rat. Jap. J. Pharmacol., 24: 357–361, 1974.
Harada, M. and Yano, S.: Inhibitory effect of N-acetyl-L-glutamine aluminum complex (KW) and related compounds on gastric erosion and motility in stressed animals. Ōyo Yakuri (Jap.), 8: 1–6, 1974.
Yamagata, S., Ishimori, A., Sato, H., Okabe, H., Ishihara, K., Yugawa, N., Masuda, M., Ishihara, M., Sakita, T., Ashizawa, S., Tsuneoka, K., Kaido, I., Wada, T. and Namiki, M.: Clinical evaluation of pharmacotherapy for peptic ulcer with antipepsin agents by double-blind technique—Multicenter clinical study. Tohoku J. exp. Med., 110: 377–404, 1973.
Yamagata, S., Ishimori, A., Miura, Y., Ashizawa, S., Nakano, H., Tsuneoka, K., Saito, Y., Takemoto, T., Kurokawa, K., Masuda, M., Kawai, K., Ida, K., Sato, H. and Taneda, T.: A phase II clinical trial of N-acetyl-L-glutamine aluminum complex (KW) in the treatment of peptic ulcer. Rinsho Seijinbyo (Jap.), 4: 423–427, 1974.
Doll, R., Hill, I.D., Hutton, C. and Underwood, D.J., II: Clinical trial of a triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet, 2: 793–796, 1962.
Horwich, L. and Galloway, R.: Treatment of gastric ulceration with carbenoxolone sodiumclinical and radiological evaluation. Brit. Med. J., 2: 1274–1277, 1965.
Turpie, A.G.G. and Thompson, T.J.: Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects. Gut, 5: 591–594, 1965.
Ottenjann, R. and Rösch, W.: Therapie des Ulcus ventriculi mit Carbenoxolone-Natrium-Ergebnisse eines Doppelblindversuchs. Med. Klin., 65: 74–77, 1970.
Brown, P., Salmon, P.R. and Read, A.E.: Doubleblind trial of carbenoxolone sodium capsules in duodenal ulcer therapy, based on endoscopic diagnosis and follow-up. Brit. Med. J., 3: 661–664, 1972.
Hollander, D. and Harlan, J.: Antacids vs. placebos in peptic ulcer therapy-A controlled double-blined investigation. J. Amer. Med. Assoc, 226: 1181–1185, 1973.
Engqvist, A., Feilitzen, F.V., Pyk, E. and Reichard, H.: Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer. Gut. 14: 711–715, 1973.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamagata, S., Ishimori, A., Satō, H. et al. Clinical course of peptic ulcer and the effect of pharmacotherapy. Gastroenterol Jpn 10, 323–341 (1975). https://doi.org/10.1007/BF02776363
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02776363