Summary
In cases with ulcer disease and gastritis with preserved acidity, electrophoregrams were close to normal.
In gastric cancer with free hydrochloric acid, the central fractions (near the point of application) were increased.
In achylia and mucosal atrophy, the most mobile anodic fractions (pepsin and mucoprotein) and cathodic components were absent and the intensity of central bands was enhanced. In approximately half the patients albumin spots were detected.
In contrast to achylia petients without tumour, massive albumin spots and large contents of cathodic components were often noted in gastric cancer patients.
Electrophoretic analysis of protein products of gastric juice provides a more or less correct indication as to the character of gastric secretion and gives an idea on the production of individual gastric juice components, including, among others, pepsin, mucoprotein, mucoproteoses, and albumin; it also characterizes, to a certain extent, the state of both the glandular apparatus and the surface epithelium of gastric mucosa. The main clinical significance of this method lies in the fact that it makes possible to obtain data indicative of mucosal atrophy and cancer of the stomach.
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Abasov, I.T. Electrophoresis of gastric juice proteins in gastric diseases. Gastroenterol Jpn 4, 273–279 (1969). https://doi.org/10.1007/BF02775799
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DOI: https://doi.org/10.1007/BF02775799