Skip to main content
SpringerLink
Log in

Passage of serum albumin into the stomach

Its detection by paper electrophoresis of gastric juice in protein-losing gastropathies and gastric cancer

  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Conclusions

The presence of serum albumin in the gastric lumen can be readily diagnosed by paper electrophoresis of the gastric juice. While small amounts of albumin are present in the gastric juice under normal conditions, a massive leakage of serum albumin into the stomach occurs often in gastric cancer, Menetrier's disease, and in some cases of gastric atrophy. Paper electrophoresis of the gastric juice has definite clinical significance for the detection of these conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Citrin, Y., Sterling, K., andHalsted, J. A. The mechanism of hypoproteinemia associated with giant hypertrophy of the gastric mucosa.New Engl. J. Med. 257:906, 1957.

    PubMed  Google Scholar 

  2. Schwartz, M., andJarnum, S. Gastrointestinal protein loss in idiopathic (hypercatabolic) hypoproteinaemia.Lancet 1:327, 1959.

    Article  PubMed  Google Scholar 

  3. Schwartz, M., andThomsen, B. Idiopathic and hypercatabolic hypoproteinemia.Brit. Med. J. 1:14, 1957.

    Google Scholar 

  4. Gordon, R. S., Jr. Exudative enteropathy: abnormal permeability of the gastrointestinal tract demonstrable with labelled polyvinylpyrrolidone.Lancet 1:325, 1959.

    Article  PubMed  Google Scholar 

  5. Gordon, R. S., Jr., Bartter, F. C., andWaldmann, T. Idiopathic hypoalbuminemias.Ann. Med. 51:553, 1959.

    Google Scholar 

  6. Young, W. F., Levin, B., Fowler, J. F., andMiles, J. M. Gastrointestinal protein loss in severe malabsorption complicated by idiopathic (hypercatabolic) hypoproteinaemia.Lancet 2:85, 1959.

    Article  PubMed  Google Scholar 

  7. Hsia, D. Y., White, H., andHugh-Jones, K. Idopathic hypoproteinemia.Clin. Res. 7:392, 1959.

    Google Scholar 

  8. Holman, H., Nickel, W. F., Jr., andSleisenger, M. H. Hypoproteinemia antedating intestinal lesions, and possibly due to excessive serum protein loss into the intestine.Am. J. Med. 27:963, 1959.

    Article  PubMed  Google Scholar 

  9. Steinfeld, J., Davidson, J., andGordon, R. A mechanism for hypoalbuminemia in patients with ulcerative colitis and regional enteritis.J. Clin. Invest. 36:931, 1957.

    Google Scholar 

  10. Editorial. Protein-losing gastroenteropathy.Lancet 1:351, 1959.

  11. Glass, G. B. J., Stephanson-Liounis, L., Rich, M., andMitchell, S. E. Paper electrophoretic analysis of gastric juice in gastric anacidity, gastric atrophy, and cancer of the stomach. Proc. World Congr. of Gastroenterology, Washington, D. C., 1958, Williams & Wilkins, Baltimore 2, Md., p. 994.

  12. Glass, G. B. J., andIshimori, A. Paper electrophoretic detection of leakage of albumin into the gastric juice in protein-losing gastropathies and gastric cancer.Federation Proc. 19:191, 1960.

    Google Scholar 

  13. Jarnum, S., andSchwartz, M. Hypoalbuminemia in gastric carcinoma.Gastroenterology 38:769, 1960.

    PubMed  Google Scholar 

  14. Glass, G. B. J., Stephanson, L., andRich, M. Paper-electrophoretic analysis of gastric juice.Federation Proc. 15:75, 1956.

    Google Scholar 

  15. Glass, G. B. J., Stephanson, L., andRich, M. Paper-electrophoretic analysis of gastric juice in health and disease and its physiological and clinical significance.Gastroenterologia 86:384, 1956.

    PubMed  Google Scholar 

  16. Rideout, L. A., andPrichard, R. W. Inexpensive stain for paper electrophoresis.Science 121:374, 1955.

    PubMed  Google Scholar 

  17. Köiw, E., andGrönwall, A. Staining of protein-bound carbohydrates after electrophoresis of serum on filter paper.Scand. J. Clin. & Lab. Invest. 4:244, 1952.

    Google Scholar 

  18. Glass, G. B. J. Paper electrophoresis of gastric juice in health and disease. In: Current Concepts in Gastroenterology. Second Postgraduate Course in Gastroenterology, Am. Coll. Phys., New Orleans, 1960 (to be published).

    Google Scholar 

  19. Glass, G. B. J., Stephanson-Liounis, L., Rich, M., andMitthell, S. E. Quantitation of pepsin in gastric juice by paper-electrophoresis.Federation Proc. 17:54, 1958.

    Google Scholar 

  20. Glass, G. B. J., Rich, M., andStephanson, L. Comparative study of mucoproteins of human gastric juice and serum.Gastroenterology 34:598, 1958.

    PubMed  Google Scholar 

  21. Ohara, H., andGlass, G. B. J. (in preparation).

  22. Hitzelberger, A. L., andGlass, G. B. J. Effect of corticosteroids on non-dialyzable substances of the gastric juice.Federation Proc. 19:190, 1960.

    Google Scholar 

  23. Gullberg, R., andOlhagen, B. Electrophoresis of human gastric juice.Nature 184:1848, 1959.

    PubMed  Google Scholar 

  24. Hollander, F., andHorowitz, M. I. Serum albumin (ALB) in canine gastric acetylcholine-mucus (Ach-Mu) and whole stomach aspirates.Federation Proc. 19:181, 1960.

    Google Scholar 

  25. Armstrong, F. B., Margen, S., andTarver, H. Plasma protein. VII. Site of degradation of serum albumin.Proc. Soc. Exper. Biol. Med. 103:592, 1960.

    Google Scholar 

  26. Salomon, E. Deut. med. Wochschr. 1:546, 1903, cited byHenning et al. (Ref. 30).

    Google Scholar 

  27. Wolff, W., andJunghans, P.,Berl. Klin. Wochschr. 2:978, 1911, Cited byHenning et al. (Ref. 30).

    Google Scholar 

  28. Katsch, G. Gastritis serosa und Gastritis mucosa.Klin. Wochschr. 2:1561, 1935.

    Article  Google Scholar 

  29. Norpoth, L., Surmann, T., Wieneken, A., andClösges, J. Erweiterung der Magendiagnostik durch den Nachweis pathologischer Eiweisskörper im Magensaft.Ärzt, Wochschr. 11:150, 1956.

    Google Scholar 

  30. Henning, N., Kinzlmeier, H., andDemling, L. Über die elektrophoretisch darstellbaren Proteine normaler und pathologischer Magensäfte.München. med. Wochschr. 95:423, 1953.

    Google Scholar 

  31. Butz, W. C. Giant hypertrophic gastritis.Gastroenterology 39:183–190, 1960.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From the Gastroenterology Research Laboratory and Department of Medicine, New York Medical College-Metropolitan Medical Center, New York, N. Y.

    George B. Jerzy Glass M.D. & Akira Ishimori M.D.

Authors
  1. George B. Jerzy Glass M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Akira Ishimori M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by Grant-in-Aid A-68 (C7 and 8) from the Institute of Arthritis and Metabolic Diseases, N.I.H., U.S.P.H.S., and Grant E-18B from the American Cancer Society.

The initial phase of this work was performed with the technical assistance of Sallie E. Mitchell, A.B. Gastric juices of 3 patients with Menetrier's disease were kindly forwarded to us by Dr. F. Kern, Jr. of the V.A. Hospital, Denver, Colorado, Dr. H. D. Janowitz of the Mount Sinai Hospital, New York, and Dr. H. Colcher of the Goldwater Memorial Hospital (Columbia Division), New York. We wish here to express to them our appreciation of their interest and courtesy. Seven of the gastric juices of patients who had proved cases of gastric cancer (Table 1) were kindly forwarded to us by Dr. Joseph A. Buckwalter of the Department of Surgery, Iowa State University Medical School, Iowa City. The able assistance of Mrs. Antonina S. Glass in preparing the graphs and of Miss Lillian E. Palliser in editing this manuscript is gratefully acknowledged.

Illustrations so identified are from the forthcoming bookCurrent Gastroenterology, Paul B. Hoeber, Inc., Medical Division of Harper & Brothers, publishers.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Glass, G.B.J., Ishimori, A. Passage of serum albumin into the stomach. Digest Dis Sci 6, 103–133 (1961). https://doi.org/10.1007/BF02231798

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02231798

Keywords

Search

Navigation