Summary
Experimental studies, using albino rabbits, showed that following the sensitization with histamine and homologous liver antigen conspicuous liver injury, closely resembling chronic active hepatitis, which progressed into liver cirrhosis with pseudolobulus formation, could be induced. The splenic weight, obtained after the administration of several hepato-toxic substances, had intimate relation with serum gammaglobulin levels. Furthermore, in a group in which splenectomy was performed after the development of hypergammaglobulinemia, serum gammaglobulin resulted in a rebound increase in comparison with extremely low level of serum gammaglobulin in a group in which splenectomized prior to sensitization.
These results may suggest that (1) autoallergic mechanism must be taken into consideration on the development of chronic liver disorders and the role of the histamine should never be ignored. (2) splenomegaly in chronic liver diseases should not be considered from hemodynamic disturbance alone, but one of the important reacting sites where many factors including antigen antibody reaction are involved.
Similar content being viewed by others
References
Ishii, K. and Suzuki, O.:Role of the spleen in liver diseases-Clinical and experimental study from immunological aspect-. Acta Hepatologica Japanica, 15: 30, 1974 (in Japanese).
Kuniyasu, Y.: Clinical study of hepatoscintigram. Jap. J. Gastroenterol., 63: 538, 1966 (in Japanese).
Sambe, K., Tsuchiya, M. et al.: Diagnostic value of hepatoscintigram. Keio Igaku, 43: 477, 1966 (in Japanese).
Kiryu, Y., Ishii, K. et al.: Allergic factors and mechanism of the development of hypergammaglobulinemia in liver diseases. Acta Hepatologica Japonica, 10: 431, 1969 (in Japanese).
Ishii, K.: Experimental study on the chronicity of liver injuries-with special reference to autoallergic mechanism and the effect of follicular hormone-. Acta Hepatologica Japonica, 13: 270, 1972 (in Japanese).
von Herrath, E.: Die Morphologie des Retothelialen Systems. Verh. Dtsch. ges. Path., 137: 13, 1953.
Duesberg, R. und Gramlich, F.: Die Milz, ein defensives und aggresives Organ. Dtsch. med. Wschr., 89: 153, 1964.
Schneidenbaur, A.: Ein besonderer Fall von hepatitischer Leberzirrhose mit Splenitis, plasmazellulärer Reaktion und Hyperproteinämie. Wiener med. Wschr., 108: 19, 1958.
Ellis, E.F. and Smith, R.T.: The role of the spieen in immunity, with special reference to the post-splenectomy problem in infants. Pediatrics, 37: 111, 1966.
Streicher, H.J., Hartung, H. et al.: Milz/ Leberbeziehungen am Modell der experimentellen Thioacetamid-Cirrhose der Rattenleber. In Die Milz, Springer Verlag, Berlin, Heidelberg, 1970, S. 347.
Gramlich, F., Fischer, J. et al.: Die Milz bei Leberkrankungen. in Die Milz, Springer Verlag, Berlin, Heidelberg, 1970, S. 336.
Westling, H. and Wetterqvist, H.: The sex difference in histamine methylation in the rat. XXII Int. Cong. Physiol. Leyden, No. 691, 1962.
Suzuki, O.: Hyperhistaminemia in liver diseases -Clinical and experimental studies-. Acta Hepatologica Japonica, 14: 370, 1973.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ishii, K., Suzuki, O., Kiryu, Y. et al. Role of the splfen in hepatic disorders. Gastroenterol Jpn 10, 168–173 (1975). https://doi.org/10.1007/BF02774846
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02774846