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Influence of methionine-enkephalin analogue (FK-33-824) on the secretion of pancreatic hormones

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Summary

To determine the effects of methionine-enkephalin on secretion of pancreatic hormones, five healthy male adults were intramuscularly given 0.5 mg of FK 33-824, a methionine-enkephalin analog and blood levels of pancreatic hormones were measured at different time intervals.

FK 33-824 significantly lowered basal levels of plasma insulin (IRI) and pancreatic polypeptide and decreased IRI secretion in 75 g-OGTT. It also delayed the elevation of blood sugar level in 75g-OGTT. No change occurred in the basal levels of plasma glucagon, somatostatin and blood sugar. These results imply that methionine-enkephalin in the pancreas and alimentary tract may act as an inhibitor on the secretion of insulin and pancreatic polypeptide and hence relates to the absorption of sugar.

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Authors and Affiliations

  1. 3rd Department of Internal Medicine, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, 812, Higashi-ku, Fukuoka, Japan

    Kensaku Sekiya M.D., Akihiro Funakoshi M.D., Hirotsugu Shinozaki M.D., Hajime Nawata M.D., Ken-ichi Kato M.D. & Hiroshi Ibayashi M.D.

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  1. Kensaku Sekiya M.D.
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  2. Akihiro Funakoshi M.D.
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  3. Hirotsugu Shinozaki M.D.
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  4. Hajime Nawata M.D.
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  5. Ken-ichi Kato M.D.
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  6. Hiroshi Ibayashi M.D.
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Sekiya, K., Funakoshi, A., Shinozaki, H. et al. Influence of methionine-enkephalin analogue (FK-33-824) on the secretion of pancreatic hormones. Gastroenterol Jpn 20, 252–259 (1985). https://doi.org/10.1007/BF02774712

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  • DOI: https://doi.org/10.1007/BF02774712

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