Skip to main content

Advertisement

SpringerLink
Log in

Inhibition of gastric secretion by intraduodenal hypertonic glucose in patients with duodenal ulcer

  • Original Article
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

Intraduodenal instillation of hypertonic glucose significantly inhibited tetragastrin-induced gastric acid and pepsin outputs in man. The secretory volume of gastric juice was markedly decreased, whereas, acid concentration remained unchanged. Pepsin concentration, on the contrary, was reduced significantly. The degree of inhibition of pepsin output, therefore, was greater than that of acid output. No significant difference in the extent of inhibition of acid or pepsin output was observed between control subjects and patients with duodenal ulcer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Halvorsen HC, Middleton MD, Bibler DD, et al: Influence of the vagus nerve on the inhibitory effect of fat in the duodenum. Am J Dig Dis 11: 911–917, 1966

    Article  Google Scholar 

  2. Ward AS: The effect of vagotomy on the inhibition of gastric secretion by intraduodenal fat. Brit J Surg 7: 533–536, 1973

    Article  Google Scholar 

  3. Johnston D and Duthie HL: Effect of acid in the duodenum on histamine-stimulated gastric secretion in man. Gut 5: 573–580, 1964

    Article  PubMed  CAS  Google Scholar 

  4. Ward AS: The effect of vagotomy on the inhibition of gastric secretion by intraduodenal acid. Brit J Surg 61: 698–704, 1974

    Article  PubMed  CAS  Google Scholar 

  5. Ward AS, Wilkins RA, Cockel R, et al: Duodenal inhibition of gastric secretion by osmotic agents in normal subjects and patients with duodenal ulcer. Gut 10:1020–1028, 1969

    Article  PubMed  CAS  Google Scholar 

  6. Shay H, Gershon-Cohen J, Fels SS, et al: Concerning the influence of glucose on the response of the human stomach to test meals. Am J Dig Dis 9: 363–367, 1942

    CAS  Google Scholar 

  7. Anson ML: The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin. J Gen Physiol 22: 79–89, 1938

    Article  CAS  Google Scholar 

  8. Windsor CWO, Cockel R, Lee MJR: Inhibition of gastric secretion in man by intestinal fat infusion. Gut 10:135–142, 1969

    Article  PubMed  CAS  Google Scholar 

  9. Hobsley M and Silen W: Use of an inert marker (phenol red) to improve accuracy in gastric secretion studies. Gut 10: 787–795, 1969

    Article  PubMed  CAS  Google Scholar 

  10. Ward AS: Effect of vagotomy on the gastric secretion in man by intestinal fat infusion. Gut 10: 135–142, 1969

    Article  Google Scholar 

  11. Sircus W: Studies on the mechanism in the duodenum inhibiting gastric secretion. Quart J Exp Physiol 43: 114–133, 1958

    CAS  Google Scholar 

  12. Shay H, Gershon-Cohen J, Fels SS: A self-regulatory duodenal mechanism for gastric acid control and an explanation for pathologic gastric physiology in uncomplicated duodenal ulcer. Am J Dig Dis 9: 124–128, 1942

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. First Department of Surgery, Faculty of Medicine, University of Tokyo, 3-1 Hongo 7, Bunkyo-ku, 113, Tokyo, Japan

    Tadashi Hirata M.D., Masayoshi Tani M.D., Takeo Yamagishi M.D. & Hisaaki Shimazu M.D.

Authors
  1. Tadashi Hirata M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masayoshi Tani M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takeo Yamagishi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hisaaki Shimazu M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hirata, T., Tani, M., Yamagishi, T. et al. Inhibition of gastric secretion by intraduodenal hypertonic glucose in patients with duodenal ulcer. Gastroenterol Jpn 13, 28–32 (1978). https://doi.org/10.1007/BF02774151

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02774151

Key Words

Search

Navigation