Skip to main content

Advertisement

Log in

Serum glycoproteins in the liver diseases III. desialylated glycoproteins in the acute hepatitis

  • Original Article
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

Circulating desialylated glycoprotein level in acute hepatitis was studied by using the competitive binding assay reported by us. Statistically significant differences of the level among acute hepatitis in the peak of illness, fulminating hepatitis and normal subjects were observed. The desialylated glycoprotein level in acute hepatitis was elevated associating with S-GPT and serum bilirubin levels, and it returned to the normal range before S-GPT and serum bilirubin were normalized. The desialylated glycoprotein in a fulminant hepatitis was increasing associated with bilirubin even when S-GPT was decreasing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Morell, A.G., Irvine, R.A., Sternlieb, I., Scheinberg, I.H. and Ashwell, G.: Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo. J. Biol. Chem., 243: 155–159, 1968.

    PubMed  CAS  Google Scholar 

  2. Van Den Hamer, C.J.A., Morell, A.G. and Scheinberg, I.H.: Physical and chemical studies on ceruloplasmin. IX. The role of galactosyl residues in the clearance of ceruloplasmin from the circulation. J. Biol. Chem., 245: 4397–4402, 1970.

    Google Scholar 

  3. Gregoriadis, G., Morell, A.G., Sternlieb, I. and Scheinberg, I.H.: Catabolism of desialylated ceruloplasmin in the liver. J. Biol. Chem., 245: 5833–5837, 1970.

    PubMed  CAS  Google Scholar 

  4. Marshall, J.S., Green, A.M., Pensky, J., Williams, A.Z. and Carlson, D.M.: Measurement of circulating desialylated glycoproteins and correlation with hepatocellular damage. J. Clin. Invest., 54: 555–562, 1974.

    Article  PubMed  CAS  Google Scholar 

  5. Arima, T., Motoyama, Y., Yamamoto, T., Nagata, K. and Kondo, T.: Serum glycoproteins in the liver diseases. I. Studies on sialic acid-free glycoproteinsimproved competitive binding assay of desialylated glycoprotein by plasma membrane of rat liver. Gastroent. Jap. 11: 300–306, 1976.

    CAS  Google Scholar 

  6. Spiro, R.G.: Glycoproteins. Ann. Rev. Biochem., 39: 599–638, 1970.

    Article  PubMed  CAS  Google Scholar 

  7. Morell, A.G., Gregoriadis, G. and Scheinberg, I.H.: The role of sialic acid in determining the survival of glycoproteins in the circulation. J. Biol. Chem., 246: 1461–1467, 1971.

    PubMed  CAS  Google Scholar 

  8. Pricer, W.E. and Ashwell, G.: The binding of desialylated glycoproteins by plasma membranes of rat liver. J. Biol. Chem., 246: 4825–4833, 1971.

    PubMed  CAS  Google Scholar 

  9. Van Lenten, L. and Ashwell, G.: The binding of desialylated glycoproteins by plasma membrane of rat liver. J. Biol. Chem., 247: 4633–4640, 1972.

    PubMed  Google Scholar 

  10. Kawasaki, T. and Ashwell, G.: Chemical and physical properties of an hepatic membrane protein that specifically binds asialoglycoproteins. J. Biol. Chem., 251: 1296–1302, 1976.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arima, T., Motoyama, Y., Yamamoto, T. et al. Serum glycoproteins in the liver diseases III. desialylated glycoproteins in the acute hepatitis. Gastroenterol Jpn 12, 39–42 (1977). https://doi.org/10.1007/BF02773623

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02773623

Key Words

Navigation