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Single-dose cefodizime as infection prophylaxis in abdominal surgery: A prospective multicenter study

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This prospective pilot study was performed to evaluate the efficacy, safety and tolerability of a single dose of cefodizime as infection prophylaxis in patients undergoing major abdominal surgery. One hundred forty-nine patients received 2 g cefodizime, a third-generation cephalosporin, 30 min before abdominal surgery. The mean operation time was 116±66 min. Eighteen patients received metronidazole additionally. In 8/149 patients (5.4%) the final outcome was considered to be a treatment failure. 94.6% of the patients had no signs of infection. The long half-life of cefodizimes allows a single-dose perioperative prophylaxis even in abdominal surgery lasting 3 to 4 h. Cefodizime can be regarded as a safe antibiotic prophylaxis with few side effects.

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Authors and Affiliations

  1. Klinische Abt. für Infektionen und Chemotherapie, Universitätskinik für Innere Medizin I, Währinger Gürtel 18-20, A-1090, Wien

    F. Thalhammer, F. Traunmüller cand. med., U. Hollenstein Univ.-Doz., H. Burgmann Univ.-Prof. & S. Breyer

  2. Chirurgische Abt., A. ö. Krankenhaus der Elisabethinen, Fadingerstr. 1, A-4010, Linz

    H. J. Böhming

  3. Chirurgische Abt., Krankenhaus Wr. Neustadt, Corvinusring 3-5, A-2700, Wr.Neustadt

    D. Depisch

  4. Abt. für Anästhesie, Krankenhaus der Barmherzigen Brüder, Große Mohrengasse 9, A-1020, Wien

    W. Ilias

  5. Chirurgische Abt., A. ö. Krankenhaus St. Pölten, Propst-Führer-Str. 4, A-3100, St. Pölten

    G. Salem

  6. Chirurgische Abt., A. ö. Krankenhaus Linz, II, Krankenhausstr. 9, A-4020, Linz, Austria

    W. Wayand

Authors
  1. F. Thalhammer
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  2. F. Traunmüller cand. med.
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  3. H. J. Böhming
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  4. D. Depisch
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  5. W. Ilias
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  6. U. Hollenstein Univ.-Doz.
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  7. G. Salem
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  8. W. Wayand
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  9. H. Burgmann Univ.-Prof.
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  10. S. Breyer
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Thalhammer, F., Traunmüller, F., Böhming, H.J. et al. Single-dose cefodizime as infection prophylaxis in abdominal surgery: A prospective multicenter study. Infection 26, 136–138 (1998). https://doi.org/10.1007/BF02767780

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  • DOI: https://doi.org/10.1007/BF02767780

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