Abstract
The DNA synthesis in the myocardium and liver of 5–7-day-old albino rats after intraperitoneal injection of selective antagonist of μ-opioid receptors A10 (H-Tyr-D-Orn-Phe-Gly-OH) are studied using3H-thymidine autography. In the myocardium, both single (70 µg/kg) and 5-fold (100 µg/kg) administration of A10 significantly increases the intensity of labeling. The 5-fold administration of A10 induces an increase in abolute and relative mass of the heart. In the liver, the number of DNA-synthesizing hepatocytes rises in all experimental series. These data attest to a stimulating effect of μ-agonist on physiological regeneration of the myocardium and liver of albino rats in early postnatal ontogeny.
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Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 2, pp. 212–215, February, 1997
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Goncharova, E.N., Mel’nikova, N.P., Yatsenko, T.V. et al. Effect of tetrapeptide A10, an agonist of μ-opioid receptors, on DNA synthesis in the myocardium and liver of albino rats in early postnatal ontogeny. Bull Exp Biol Med 123, 184–187 (1997). https://doi.org/10.1007/BF02766447
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DOI: https://doi.org/10.1007/BF02766447