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Effect of long-term parenteral administration of empty andl-Dopa-loaded liposomes on the turnover of dopamine and its metabolites in the striatum of mice with experimental Parkinson’s syndrome

  • General Pathology and Pathological Physiology
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Abstract

It is found that the dose ofl-Dopa required for correction of dopamine metabolism in experimental Parkinson’s syndrome in C57B1/6 mice can be reduced 10-fold when the preparation is incorporated into small unilamellar liposomes (60 nm) composed from egg yolk phosphatidylcholine and cholesterol (7:3). High-performance liquid chromatography shows that a 14-day treatment with bothl-Dopa incorporated into liposomes (5 mg/kg) and freel-Dopa (50 mg/kg) equally increases the content of dopamine and homovanillic acid and their ratio in mouse striatum. The content of dihydroxyphenylacetic acid markedly increases after administration of freel-Dopa.

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Authors and Affiliations

  1. Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, USSR

    V. V. Yurasov, V. G. Kucheryanu, V. S. Kudrin, I. V. Zhigal’tsev, E. V. Nikushkin, Yu. G. Sandalov, A. P. Kaplun & V. I. Shvets

  2. Department of Biotechnology, M. V. Lomonosov Institute of Fine Chemical Technology, Moscow

    A. P. Kaplun & V. I. Shvets

Authors
  1. V. V. Yurasov
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  2. V. G. Kucheryanu
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  3. V. S. Kudrin
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  4. I. V. Zhigal’tsev
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  5. E. V. Nikushkin
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  6. Yu. G. Sandalov
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  7. A. P. Kaplun
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  8. V. I. Shvets
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Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 2, pp. 150–153, February, 1997

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Yurasov, V.V., Kucheryanu, V.G., Kudrin, V.S. et al. Effect of long-term parenteral administration of empty andl-Dopa-loaded liposomes on the turnover of dopamine and its metabolites in the striatum of mice with experimental Parkinson’s syndrome. Bull Exp Biol Med 123, 126–129 (1997). https://doi.org/10.1007/BF02766431

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  • DOI: https://doi.org/10.1007/BF02766431

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