Abstract
The modification of hyaluronidase by aldehydodextran regulates inhibition of the enzyme by heparin. A 70–90% modification of the surface amino groups of hyaluronidase results in sharp conformational changes and a substantial decrease of its inhibition by heparin, whereas hyaluronidase derivatives with a modification degree of 96–100% are practically uninhibited.
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Maksimenko, A.V., Petrova, M.L., Tishchenko, E.G. et al. Chemical modification of hyaluronidase as a means to regulate its inhibition by heparin. Russ J Bioorg Chem 26, 322–326 (2000). https://doi.org/10.1007/BF02759284
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DOI: https://doi.org/10.1007/BF02759284