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Inhibitory effects of flavonoids on several venom hyaluronidases

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Abstract

In vitro studies showed that the flavonoid aglycones apigenin, luteolin and kaempferol inhibited the hyaluronidase activity of five different venoms dose-dependently. They were also able to delay the venom action when injected into mice. Naringenin, catechin and flavonoid glycosides had no effect. The flavonoids with unsubstituted hydroxyl groups at C-positions 5, 7 and 4′, a double bond between carbons 2 and 3, as well as a ketone group at position 4, exhibited potent inhibitory actions on the venom hyaluronidases.

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Authors and Affiliations

  1. Laboratory of Flavonoid Research, Department of Biochemistry, Faculty of Medicine, National University of Singapore, Kent Ridge Crescent, 0511, Singapore

    U. R. Kuppusamy & N. P. Das

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  1. U. R. Kuppusamy
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  2. N. P. Das
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Kuppusamy, U.R., Das, N.P. Inhibitory effects of flavonoids on several venom hyaluronidases. Experientia 47, 1196–1200 (1991). https://doi.org/10.1007/BF01918384

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  • DOI: https://doi.org/10.1007/BF01918384

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