Skip to main content
Log in

Current treatment and prognosis of Wilms’ tumor

  • Symposium: Hematology/Oncology—II
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Summary

Thanks to the nationally and internationally organized efforts refinements in the therapy of Wilms’ tumor have allowed restructuring and reduction of therapeutic strategies. A decrease in tumor relapse and long term sequelae are the immediate goals which will no doubt be the result of tailoring chemotherapy and radiation therapy exposure together with improved surgical techniques and outstanding supportive care.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Parkin DM, Stiller CA, Draper NJ. International incidence of childhood cancer.International Agency for Research in Cancer, Lyon; 1988: pp 357.

  2. Breslow NE, Langholz. Childhood cancer incidence, geographical and temporal variations.Int J Cancer 1983; 32: 703.

    Article  PubMed  CAS  Google Scholar 

  3. Breslow N, Beckwith JB, Ciol et al. Age distribution of Wilms' tumor. Report from the National Wilm's tumor study.Cancer Res 1988; 48: 1653–1657.

    PubMed  CAS  Google Scholar 

  4. Gaynow PS, Nachman J, Wolf J. Chemotherapy of Wilms' tumor. In: Pochedly C, Baun ES, eds.Wilms' Tumor, Clinical and Biological Manifestations. Elsevier Science Publishers, 1984.

  5. Fabia J, Thy JD. Occupation of the father at the time of birth of children dying of malignant disease.Br J Q Prev Soc Med 1974; 28: 98–100.

    CAS  Google Scholar 

  6. Breslow NE, Beckwith JB. Epidemiological features of Wilm's tumor, results of the national Wilms' tumor study.J Natl Cancer Inst 1982; 68: 429–436.

    PubMed  CAS  Google Scholar 

  7. Riccardi VM, Sujansky E, Smith AC et al. Chromosomal imbalance in the aniridia-Wilms’ tumor association 11 p interstitial deletion.Pediatrics 1978; 61:604–610.

    PubMed  CAS  Google Scholar 

  8. Kaneko Y, Homma C, Maseki N et al. Correlation of chromosome abnormalities with histological and clinical features in Wilms’ and other childhood renal tumors.Cancer Res 1991; 51: 5937–5942.

    PubMed  CAS  Google Scholar 

  9. Myrianthopolou NC, Chung CS. Congenital malformation in singletons. Epidemiological survey.Brith Defects 1974; 10(11): 1–58.

    Google Scholar 

  10. Teele RL. Ultrasonography of the genitourinary tract.Radiol Clin North Am 1977; 15: 109–128.

    PubMed  CAS  Google Scholar 

  11. Sukarochana K, Tolentino W, Kiesewetter WB. Wilms' tumor and hypertension.J Pediatr Surg 1972; 7: 573–578.

    Article  PubMed  CAS  Google Scholar 

  12. Ramsay NKC, Dehner LP, Coccia F et al. Acute hemmorrhage into Wilms' tumor.J Pediatr 1977; 91:763–765.

    Article  PubMed  CAS  Google Scholar 

  13. Rosenfeld M, Rodgers BM, Talbert L. Wilms' tumor with acute abdominal pain.Arch Surg 1977; 112:1080–1082.

    PubMed  CAS  Google Scholar 

  14. Clayman RV, Sheldon CA, Gonzales R. Wilms' tumor, an approach to vena cava intrussion.Prog Pediatr Surg 1982; 15: 285–305.

    PubMed  CAS  Google Scholar 

  15. Mixter CG. Malignant tumor of the kidney in infancy and childhood.Ann Surg 1932; 96: 1017–1027.

    Article  PubMed  CAS  Google Scholar 

  16. Oberholzer H, Falkson G, De Jager LC. Successful management for inferior vena cava and right atrial nephroblastoma tumor thrombus with preoperative chemotherapy.Med Pediatr Oncol 1992; 20: 61–63.

    Article  PubMed  CAS  Google Scholar 

  17. Longaker M, Harrison M, Adzick S et al. Nephron sparing approach to bilateral Wilms' tumor:In situ orex vivo surgery and radiation therapy.J Pediatr Surg 1990; 25(4): 411–414.

    Article  PubMed  CAS  Google Scholar 

  18. Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms’ tumor.Cancer 1978; 41: 1937–1948.

    Article  PubMed  CAS  Google Scholar 

  19. D'Angio GJ, Tefft M, Breslow N. Radiation therapy of Wilms' tumor-Results according to dose, field, post operative timing and histology.Int J Radiat Oncol Biol Phys 1978; 4:769–780.

    PubMed  Google Scholar 

  20. Green DM, Finklestein JZ, Breslow NE. Remaining problems in the treatment of patients with Wilms’ tumor. Soild tumors in children.Pediatr Clin North Am 1991; 38(2): 475–488.

    PubMed  CAS  Google Scholar 

  21. Oberholzer H, Falkson G, De Jager LC. Successful management of inferior vena cava and right atrial nephroblastoma tumor thrombus with preoperative chemotherapy.Med Pediatr Oncol 1992; 20: 61–63.

    Article  PubMed  CAS  Google Scholar 

  22. Thomas PRM, Tefft M, D’Angio GJ. Relapse pattern in irradiated Second National Wilms' tumor study (NWTS 2) (Abstract).Proc ASCO 1983; 2:69.

    Google Scholar 

  23. Barnard JA, Marshall GS, Neblett WW et al. Noncirrhotic portal fibrosis after Wilms’ tumor therapy.Gastroenterology 1986; 90: 1054–1056.

    PubMed  CAS  Google Scholar 

  24. Bjork O, Eklof O, Willis U. Veno-occulsive disease and peliosis of the liver complicating the course of Wilms’ tumor.Acta Radiol 1985; 26: 589–597.

    CAS  Google Scholar 

  25. The child cure of cancer. A problem for the intermist.Semin Oncol 1982; 9: 142–149.

    Google Scholar 

  26. Kinsella JP, Brasch RC, Ablin AS. Unilateral hypoplasia of the hemithorax causing “pseudo scoliosis” after lung irradiation in a child with Wilms’ tumor.Pediatr Radiol 1985; 15: 340–342.

    Article  PubMed  CAS  Google Scholar 

  27. Smith R, Davidson JK, Flatman GE. Skeletal effects of orthovoltage and megavoltage therapy following treatment of nephroblastoma.Clin Radiol 1982; 33: 601–613.

    Article  PubMed  CAS  Google Scholar 

  28. Green DM, Breslow NE, Li Y et al. The role of surgical excision in the management of relapsed Wilms’ tumor patients with pulmonary metastases: A report of the National Wilms’ tumor study.J Pediatr Surg 1991; 26(6): 728–733.

    Article  PubMed  CAS  Google Scholar 

  29. Welch TR, Mc Adams AJ. Focal glomerulo-sclerosis as a late sequela of Wilms’ tumor.J Pediatr 1986; 108: 105–109.

    Article  PubMed  CAS  Google Scholar 

  30. Lipshultz SE, Colan SD, Sanders S et al. Late cardiac effects of doxorubicin in childhood ALL (Abstract).Blood 1987; 70: 234a.

    Google Scholar 

  31. Steinherz L, Steinherz P, Tan C et al. Cardiac toxicity 4–20 years after completing anthracycline therapy (Abstract).Proc Am Soc Clin Oncol 1989; 8: 296.

    Google Scholar 

  32. Li FP, Yan JC, Sallan S et al. Second neoplasms after Wilms’ tumor in childhood.J Nat Cancer Inst 1983; 71: 1205–1209.

    PubMed  CAS  Google Scholar 

  33. Li FP, Fine W, Jaffe N. Offspring of patients treated for cancer in childhood.J Nat Cancer Inst 1979; 62: 1193–1197.

    PubMed  CAS  Google Scholar 

  34. Li FP, Gimbrere K, Gelber RD. Adverse pregnancy outcome after radiotherapy for childhood Wilms’ tumor.Proc ASCO 1986; 5: 202.

    Google Scholar 

  35. Grundy Paul, Breslow N, Green Daniel et al. Prognostic factors for children with recurrent Wilms’ tumor: Results from the Second and Third National Wilms’ tumor study.J Clin Oncol 1989; 7 (5): 636–647.

    Google Scholar 

  36. D’Angio GJ, Breslow N, Beckwiths et al. Treatment of Wilms’ tumor.Results of the Third National Wilms’ tumor study cancer. 1989; 69: 349–360.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Regueira, O., Warrier, R.P., Yu, L.C. et al. Current treatment and prognosis of Wilms’ tumor. Indian J Pediatr 60, 551–558 (1993). https://doi.org/10.1007/BF02751433

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02751433

Keywords

Navigation