Summary
Thanks to the nationally and internationally organized efforts refinements in the therapy of Wilms’ tumor have allowed restructuring and reduction of therapeutic strategies. A decrease in tumor relapse and long term sequelae are the immediate goals which will no doubt be the result of tailoring chemotherapy and radiation therapy exposure together with improved surgical techniques and outstanding supportive care.
Similar content being viewed by others
References
Parkin DM, Stiller CA, Draper NJ. International incidence of childhood cancer.International Agency for Research in Cancer, Lyon; 1988: pp 357.
Breslow NE, Langholz. Childhood cancer incidence, geographical and temporal variations.Int J Cancer 1983; 32: 703.
Breslow N, Beckwith JB, Ciol et al. Age distribution of Wilms' tumor. Report from the National Wilm's tumor study.Cancer Res 1988; 48: 1653–1657.
Gaynow PS, Nachman J, Wolf J. Chemotherapy of Wilms' tumor. In: Pochedly C, Baun ES, eds.Wilms' Tumor, Clinical and Biological Manifestations. Elsevier Science Publishers, 1984.
Fabia J, Thy JD. Occupation of the father at the time of birth of children dying of malignant disease.Br J Q Prev Soc Med 1974; 28: 98–100.
Breslow NE, Beckwith JB. Epidemiological features of Wilm's tumor, results of the national Wilms' tumor study.J Natl Cancer Inst 1982; 68: 429–436.
Riccardi VM, Sujansky E, Smith AC et al. Chromosomal imbalance in the aniridia-Wilms’ tumor association 11 p interstitial deletion.Pediatrics 1978; 61:604–610.
Kaneko Y, Homma C, Maseki N et al. Correlation of chromosome abnormalities with histological and clinical features in Wilms’ and other childhood renal tumors.Cancer Res 1991; 51: 5937–5942.
Myrianthopolou NC, Chung CS. Congenital malformation in singletons. Epidemiological survey.Brith Defects 1974; 10(11): 1–58.
Teele RL. Ultrasonography of the genitourinary tract.Radiol Clin North Am 1977; 15: 109–128.
Sukarochana K, Tolentino W, Kiesewetter WB. Wilms' tumor and hypertension.J Pediatr Surg 1972; 7: 573–578.
Ramsay NKC, Dehner LP, Coccia F et al. Acute hemmorrhage into Wilms' tumor.J Pediatr 1977; 91:763–765.
Rosenfeld M, Rodgers BM, Talbert L. Wilms' tumor with acute abdominal pain.Arch Surg 1977; 112:1080–1082.
Clayman RV, Sheldon CA, Gonzales R. Wilms' tumor, an approach to vena cava intrussion.Prog Pediatr Surg 1982; 15: 285–305.
Mixter CG. Malignant tumor of the kidney in infancy and childhood.Ann Surg 1932; 96: 1017–1027.
Oberholzer H, Falkson G, De Jager LC. Successful management for inferior vena cava and right atrial nephroblastoma tumor thrombus with preoperative chemotherapy.Med Pediatr Oncol 1992; 20: 61–63.
Longaker M, Harrison M, Adzick S et al. Nephron sparing approach to bilateral Wilms' tumor:In situ orex vivo surgery and radiation therapy.J Pediatr Surg 1990; 25(4): 411–414.
Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms’ tumor.Cancer 1978; 41: 1937–1948.
D'Angio GJ, Tefft M, Breslow N. Radiation therapy of Wilms' tumor-Results according to dose, field, post operative timing and histology.Int J Radiat Oncol Biol Phys 1978; 4:769–780.
Green DM, Finklestein JZ, Breslow NE. Remaining problems in the treatment of patients with Wilms’ tumor. Soild tumors in children.Pediatr Clin North Am 1991; 38(2): 475–488.
Oberholzer H, Falkson G, De Jager LC. Successful management of inferior vena cava and right atrial nephroblastoma tumor thrombus with preoperative chemotherapy.Med Pediatr Oncol 1992; 20: 61–63.
Thomas PRM, Tefft M, D’Angio GJ. Relapse pattern in irradiated Second National Wilms' tumor study (NWTS 2) (Abstract).Proc ASCO 1983; 2:69.
Barnard JA, Marshall GS, Neblett WW et al. Noncirrhotic portal fibrosis after Wilms’ tumor therapy.Gastroenterology 1986; 90: 1054–1056.
Bjork O, Eklof O, Willis U. Veno-occulsive disease and peliosis of the liver complicating the course of Wilms’ tumor.Acta Radiol 1985; 26: 589–597.
The child cure of cancer. A problem for the intermist.Semin Oncol 1982; 9: 142–149.
Kinsella JP, Brasch RC, Ablin AS. Unilateral hypoplasia of the hemithorax causing “pseudo scoliosis” after lung irradiation in a child with Wilms’ tumor.Pediatr Radiol 1985; 15: 340–342.
Smith R, Davidson JK, Flatman GE. Skeletal effects of orthovoltage and megavoltage therapy following treatment of nephroblastoma.Clin Radiol 1982; 33: 601–613.
Green DM, Breslow NE, Li Y et al. The role of surgical excision in the management of relapsed Wilms’ tumor patients with pulmonary metastases: A report of the National Wilms’ tumor study.J Pediatr Surg 1991; 26(6): 728–733.
Welch TR, Mc Adams AJ. Focal glomerulo-sclerosis as a late sequela of Wilms’ tumor.J Pediatr 1986; 108: 105–109.
Lipshultz SE, Colan SD, Sanders S et al. Late cardiac effects of doxorubicin in childhood ALL (Abstract).Blood 1987; 70: 234a.
Steinherz L, Steinherz P, Tan C et al. Cardiac toxicity 4–20 years after completing anthracycline therapy (Abstract).Proc Am Soc Clin Oncol 1989; 8: 296.
Li FP, Yan JC, Sallan S et al. Second neoplasms after Wilms’ tumor in childhood.J Nat Cancer Inst 1983; 71: 1205–1209.
Li FP, Fine W, Jaffe N. Offspring of patients treated for cancer in childhood.J Nat Cancer Inst 1979; 62: 1193–1197.
Li FP, Gimbrere K, Gelber RD. Adverse pregnancy outcome after radiotherapy for childhood Wilms’ tumor.Proc ASCO 1986; 5: 202.
Grundy Paul, Breslow N, Green Daniel et al. Prognostic factors for children with recurrent Wilms’ tumor: Results from the Second and Third National Wilms’ tumor study.J Clin Oncol 1989; 7 (5): 636–647.
D’Angio GJ, Breslow N, Beckwiths et al. Treatment of Wilms’ tumor.Results of the Third National Wilms’ tumor study cancer. 1989; 69: 349–360.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Regueira, O., Warrier, R.P., Yu, L.C. et al. Current treatment and prognosis of Wilms’ tumor. Indian J Pediatr 60, 551–558 (1993). https://doi.org/10.1007/BF02751433
Issue Date:
DOI: https://doi.org/10.1007/BF02751433