Abstract
Glomerular filteration rate (GFR) as determined by endogenous creatinine clearance (Cr Cl) and fractional excretion of sodium (FeNa%) as a parameter of tubular function were studied in 5 healthy newborn babies (20 term, 30 preterms with gestational age (GA) varying from 30 weeks to 36 weeks) on the first day, in the first week and second week of life. The mean values of GFR and Fena% in term babies on the first day were 18·20±1.0 ml/min/1·73 m2 and 2·86±0·2% in comparison to those of preteerm babies where the mean values were 16·40±2·3 ml/min/1·73 m2 and 3·42±0·15% respectively. The values steadily improved over a period of two weeks in both the groups, but no statistically significant improvement was noted at 5% level of significance using student's ‘T’ test, neither was there statistically significant difference in glomerular and tubular function between term and preterms of various gestationa ages.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
MaCdonald MS, Emer JL. The late intrauterine and postnatal development of human renal glomeruli.J Anat 1959;93: 331–341
Spitzer A, Brandis M. Functional and morphological maturation of superficial nephronsJ Clin Invest 1974;53: 279–283
Edelman CM Jr, Spitzer A. The maturing kidney.J Pediatr 1969;75: 509–512
Dubowitz LMS, Dubowitz V, Goldbergl. Clinical assessment of gestation in newborn infants.J Pediatr 1970;77: 1–10
Arant BS Jr. The effect of FeNa% and extracellular volume expansion on glomerulotubular balance in the developing canine kindey.Pediatr Res 1976;10: 436–440
Brod DJ, Sirota JM. The renal clearance of endogenous creatinine in man.J Clin Invest 1948;27: 645–650
Leake RD, Trygstad C. Glomerular filtration during the period of adaptation to extrauterine life.Pediatr Res 1977;11: 954–962
Siegel SR, Oh W. Renal function as a marker of human fetal maturation.Acta Pediatr Scand 1976;65: 481–485
Arant BS Jr. Developmental patterns of renal functional maturation compared in the human neonate.J Pediatr 1978;92: 705–712
Guignard JP, Torrado A, Conha OD, Gavtier E. Glomerular filtration rate in the first three weeks of life.J Pediatr 1975;87: 268–272
Aperia A, Broberger O. Postnatal development of renal functions in preterm and full term infants.Acta Pediatr Scand 1981;70: 183–187
Garlos H, Espinel. The fractional excretion of sodium test. Use in differential diagnosis of acute renal failure.JAMA 1976; 236–241
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nair, P.A.K., Mohan, V.M. & Karan, S. Study of neonatal kidney functions in preterm and term babies. Indian J Pediatr 54, 59–63 (1987). https://doi.org/10.1007/BF02751240
Issue Date:
DOI: https://doi.org/10.1007/BF02751240