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Renal function in small for gestational age preterm infants

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Abstract

Objective

The objective of this study is to compare glomerular and tubular functions in small for gestational age (SGA) and appropriate for gestational age (AGA) preterm infants.

Study Design

A prospective controlled study was conducted on SGA and AGA infants with gestational ages between 320/7 and 366/7 weeks, who received gentamycin in the first 72 h of life. Glomerular and tubular functions were assessed on days 1 and 5.

Results

Fifty (25 SGA and 25 AGA) infants were included. On day of life 1, SGA group had higher serum sodium, serum urea, and urinary creatinine. On day 5, SGA infants had significant increase in serum creatinine (p = 0.04). Urinary NAG and FeNa were comparable among the two groups on days 1 and 5.

Conclusions

Glomerular functions were compromised in SGA preterm infants. Tubular functions were comparable.

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References

  1. Antolik TL, Cunningham KJ, Alabsi S, Reimer RA. Empirical gentamicin dosing based on serum creatinine levels in premature and term neonates. Am J Health Syst Pharm. 2017;74:466–72. 2.

    Article  CAS  Google Scholar 

  2. Stritzke A, Thomas S, Amin H, Fusch C, Lodha A. Renal consequences of preterm birth. Mol Cell Pediatr. 2017;4:2.

    Article  Google Scholar 

  3. Konje JC, Okaro CI, Bell SC, de Chazal R, Taylor DJ. A cross-sectional study of changes in fetal renal size with gestation in appropriate- and small-for-gestational-age fetuses. Ultrasound Obstet Gynecol. 1997;10:22–6.

    Article  CAS  Google Scholar 

  4. Aly H, Davies J, El-Dib M, Massaro A. Renal function is impaired in small for gestational age premature infants. J Matern Fetal Neonatal Med. 2013;26:388–91.

    Article  CAS  Google Scholar 

  5. Hitron AE, Sun Y, Scarpace SB. Accuracy of empiric gentamicin dosing guidelines in neonates. J Pediatr Pharm Ther. 2010;15:264–73.

    Google Scholar 

  6. Fenton TR. A new growth chart for preterm babies: Babson and Benda’s chart updated with recent data and a new format. BMC Pediatr. 2003;3:13.

    Article  Google Scholar 

  7. Crumby T, Rinehart E, Carby MC, Kuhl D, Talati AJ. Pharmacokinetic comparison of nomogram-based and individualized vancomycin regimens in neonates. Am J Health Syst Pharm. 2009;66:149–53.

    Article  CAS  Google Scholar 

  8. Giapros VI, Cholevas VI, Andronikou SK. Acute effects of gentamicin on urinary electrolyte excretion in neonates. Pediatr Nephrol. 2004;19:322–5.

    Article  Google Scholar 

  9. Giapros V, Papadimitriou P, Challa A, Andronikou S. The effect of intrauterine growth retardation on renal function in the first two months of life. Nephrol Dial Transpl. 2007;1:96–103.

    Google Scholar 

  10. Kellum JA, Lameire N, KDIGO AKI. Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care. 2013;17:204.

    Article  Google Scholar 

  11. Jetton JG, Guillet R, Askenazi DJ, Dill L, Jacobs J, Kent AL, et al. Assessment of worldwide acute kidney injury epidemiology in neonates: design of a retrospective cohort study. Front Pediatr. 2016;4:68.

    Article  Google Scholar 

  12. Zhu J, Xing Y, Wang X-L. [A preliminary study of renal function in small-for-gestational-age infants at early stage after birth]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:389–92.

    PubMed  Google Scholar 

  13. Vehaskari VM, Aviles DH, Manning J. Prenatal programming of adult hypertension in the rat. Kidney Int. 2001;59:238–45.

    Article  CAS  Google Scholar 

  14. Gubhaju L, Sutherland MR, Yoder BA, Zulli A, Bertram JF, Black MJ. Is nephrogenesis affected by preterm birth? Studies in a non-human primate model. Am J Physiol Ren Physiol. 2009;297:F1668–77.

    Article  CAS  Google Scholar 

  15. Harris RC, Cheng H. Telomerase, autophagy and acute kidney injury. Nephron. 2016;134:145–8.

    Article  CAS  Google Scholar 

  16. Puddu M, Fanos V, Podda F, Zaffanello M. The kidney from prenatal to adult life: perinatal programming and reduction of number of nephrons during development. Am J Nephrol. 2009;30:162–70.

    Article  Google Scholar 

  17. Lulic-Botica M, Sheer T, Edwards D, Thomas RL, Natarajan G. Impact of small-for-gestational age (SGA) status on gentamicin pharmacokinetics in neonates. J Clin Pharm. 2014;54:39–45.

    Article  CAS  Google Scholar 

  18. Zanardo V, Giacobbo F, Zambon P, Trevisanuto D, Griffith P, Grella P, et al. Antenatal aminophylline and steroid exposure: effects on glomerular filtration rate and renal sodium excretion in preterm newborns. J Perinat Med. 1990;18:283–8.

    Article  CAS  Google Scholar 

  19. al-Dahan J, Stimmler L, Chantler C, Haycock GB. The effect of antenatal dexamethasone administration on glomerular filtration rate and renal sodium excretion in premature infants. Pedia Nephrol. 1987;1:131–5.

    Article  CAS  Google Scholar 

  20. Go H, Momoi N, Kashiwabara N, Haneda K, Chishiki M, Imamura T, et al. Neonatal and maternal serum creatinine levels during the early postnatal period in preterm and term infants. PLoS ONE. 2018;13:e0196721. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967735/

    Article  Google Scholar 

  21. Iacobelli S, Bonsante F, Ferdinus C, Labenne M, Gouyon J-B. Factors affecting postnatal changes in serum creatinine in preterm infants with gestational age <32 weeks. J Perinatol. 2009;29:232–6.

    Article  CAS  Google Scholar 

  22. Auron A, Mhanna MJ. Serum creatinine in very low birth weight infants during their first days of life. J Perinatol. 2006;26:755–60.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neonatology, Cleveland Clinic Children’s hospital, Cleveland, OH, USA

    Hany Aly & Indrani Bhattacharjee

  2. Department of Pediatrics, Cairo University, Cairo, Egypt

    Zahraa Ez El Din, Reem M. Soliman & May A. K. Abdellatif

  3. Department of Medical Biochemistry, Cairo University, Cairo, Egypt

    Abdelkarim Kamel

  4. Air Forced Army Hospital, Cairo, Egypt

    Hemmat Salah

Authors
  1. Hany Aly
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  2. Zahraa Ez El Din
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  3. Reem M. Soliman
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  4. Indrani Bhattacharjee
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  5. May A. K. Abdellatif
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  6. Abdelkarim Kamel
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  7. Hemmat Salah
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Correspondence to Hany Aly.

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Aly, H., Ez El Din, Z., Soliman, R.M. et al. Renal function in small for gestational age preterm infants. J Perinatol 39, 1263–1267 (2019). https://doi.org/10.1038/s41372-019-0431-9

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  • DOI: https://doi.org/10.1038/s41372-019-0431-9

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