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Dringliche Hypophysenchirurgie

Neue Wege in Diagnostik und Therapie

Urgent pituitary surgery

New ways in diagnosis and therapy

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Acta Chirurgica Austriaca Aims and scope Submit manuscript

Zusammenfassung

Eine akute intraselläre Drucksteigerung ist eine lebensbedrohliche Komplikation beim Hypophysentumor. Plötzlicher Kopfschmerz, Ophthalmoplegie und rasch zunehmende Sehverschlechterung sind die klinischen Zeichen. Sie entstehen durch Infarkt und/oder Hämorrhagie in ein Adenom und verlangen rasche operative Entlastung. Je schneller die parasellären Strukturen dekomprimiert werden, desto besser sind die postoperativen Ergebnisse.

Mit der Computertomographie und der neuen mikroneurochirurgischen Technik hat sich die Prognose dieser Erkrankung deutlich verbessert.

An Hand 4 eigener Fälle werden die Klinik, die diagnostischen Maßnahmen, die Operationstechnik und die Ergebnisse dargestellt.

Summary

Acute raise of intrasellar pressure is a life-threatening complication in pituitary tumors. Sudden headache, ophthalmoplegia and impaired visual acuity are the clinical manifestations. It is caused by rapid expansion of pituitary tumor and requires immediately surgical decompression. The faster the parasellar structures are decompressed, the better the postoperative outcomes are. The prognosis of this serious disease has been improved by computertomography and new surgical technique. This is a report of 4 cases of pituitary apoplexy. The diagnostic and therapeutic maneuvres and the outcome are discussed.

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Literatur

  1. Argires, J. P., Nelson, J.: Pituitary apoplexy: Review of the literature and two case reports. South Med. 159, 785 (1966).

    Article  Google Scholar 

  2. Auer, L. M., Clarici, G.: The first 100 transsphenoidally operated pitui tary adenomas in a non specialised centre: Surgical results and tumor recurrence. Neurol. Res. (in press).

  3. Bergland, R. M., Ray, B. S.: The arterial supply of the human optic chiasm. J. Neurosurg. 31, 327 (1969).

    CAS  PubMed  Google Scholar 

  4. Bergland, R. M., Ray, B. S., Torack, R. T.: Anatomical variations in the pituitary gland and adjacent structures in 225 human autopsy cases. J. Neurosurg. 28, 93 (1968).

    CAS  PubMed  Google Scholar 

  5. Bernstein, M., Hegele, R A., Gentili, F., Brothers, M., Holgate, R., Sturtridge, W. C., Deck, J.: Pituitary apoplexy with a triple bolus test. Case report. J. Neurosurg. 61, 586 (1984).

    CAS  PubMed  Google Scholar 

  6. Brougham, M., Heusner, A. P., Adams, R. D.: Acute degenerative changes in adenomas of pituitary body — with special reference to pituitary apoplexy. J. Neurosurg. 7, 421 (1950).

    CAS  PubMed  Google Scholar 

  7. Cardoso, E. R., Peterson, E. W.: Pituitary apoplexy: A review. Neurosurg. 14, 363 (1984).

    Article  CAS  Google Scholar 

  8. Cardoso, E. R., Peterson, E. W.: Pituitary apoplexy and vasospasm. Surg. Neurol. 20, 391 (1983).

    Article  CAS  PubMed  Google Scholar 

  9. Cartlidge, N. E. F., Shaw, D. A.: Intrasellar aneurysm with subarach-noid hemorrhage and hypopituitarysm. J. Neurosurg. 36, 640 (1972).

    CAS  PubMed  Google Scholar 

  10. Challa, V. R., Richards, F., Davis, C. H.: Interventricular hemorrhage from pituitary apoplexy. Surg. Neurol. 16, 360 (1981).

    Article  CAS  PubMed  Google Scholar 

  11. Ciric, I. S., Tarkington, J.: Transsphenoidal microsurgery. Surg. Neurol. 2, 207 (1974).

    CAS  PubMed  Google Scholar 

  12. Clarici, G.: Hypophysenapoplexy, eine dringliche Operationsindikation. Zbl. Neurochir. 47, 149 (1986).

    CAS  Google Scholar 

  13. Clarici, G., Ascher, P. W.: Funktionelle Hypophysektomie mit dem Laser. In: Verhandlungsbericht der Deutschen Gesellschaft für Lasermedizin e. V., März 1984, Graz. Hrsg. E. Keidisch, P. W. Ascher, F. Frank. Erdmann-Brenger, München-Zürich 1985.

    Google Scholar 

  14. Clarici, G., Ascher, P. W., Auer, L.: Hypophysectomy with the laser.

  15. Clarici, G., Auer, L., Tscherne, G., Leb, G., Warnkross, H., Urdl, W.: Das Amenorrhoe-Galaktorrhoe-Syndrom. Österr. Ärzteztg. 34, 1443 (1979).

    Google Scholar 

  16. Conomy, J. P., Ferguson, J. H., Brodkey, J. S., Mitsumoto, H.: Spontaneous infarction in pituitary tumors: Neurologic and therapeutic aspects. Neurology 25, 580 (1975).

    CAS  PubMed  Google Scholar 

  17. Cooperman, D. Malarkey, W. B.: Pituitary apoplexy. Heart & Lung 7, 450 (1978).

    CAS  Google Scholar 

  18. Cusick, J. F., Haughton, V. M., Hagen, T. C.: Radiological assessment of intrasellar prolactin-secreting tumors. Neurosurg. 6, 376 (1980).

    Article  CAS  Google Scholar 

  19. Dawson, B. H., Kothandaram, P.: Acute massive infarction of pituitary adenomas. A study of five patients. J. Neurosurg. 37, 275 (1972).

    CAS  PubMed  Google Scholar 

  20. De Divitiis, E., Spaziante, R., Stella, L.: Empty sella and benign intrasellarcysts. In: Advances and technical standards in neurosurgery, Vol. 8. Springer, Wien-New York 1981.

    Google Scholar 

  21. Dunn, P. J., Donald, R.A., Espiner, E. A.: Regression of acromegaly following pituitary apoplexy. Aust. NZ. J. Med. 5, 369 (1975).

    CAS  Google Scholar 

  22. Ebersold, M. J., Laws, E. R., Schetthauer, B. W., Randall, R. V.: Pituitary apoplexy treated by transsphenoidal surgery. A clinicophthological and immunocytological study. J. Neurosurg, 58, 315 (1983).

    Article  CAS  PubMed  Google Scholar 

  23. Epstein, S., Pimstone, B. L., de Villiers, J. C., Jackson, P. W.: Pituitary — apoplexy in five patients with pituitary tumors. Br. Med. J. 2, 267 (1971).

    CAS  PubMed  Google Scholar 

  24. Findling, J. W., Tyrrel, J. B., Aron, D. C., Fitzgerald, P. A., Wilson, C. B., Forsham, P. H.. Silent pituitary apoplexy: Subclinical infarction of an ACTH-producing pituitary adenoma. J. Clin. Endocrinol Metab. 52, 95 (1981).

    CAS  PubMed  Google Scholar 

  25. Fitz-Patrick, D., Tolis, G., McGarry, E. E., Taylor, S.: Pituitary apoplexy. The importance of scull roentgenograms and Computerized Tomography in diagnosis. JAMA 244, 59 (1980).

    Article  CAS  PubMed  Google Scholar 

  26. Flerko, B.: The hypophysial portal circulation today. Neuroendocrinology 30, 56 (1980).

    CAS  PubMed  Google Scholar 

  27. Fujimoto, M., Yoshino, E., Ueguchi, T., Mizukawa, N., Hirakawa, K.: Fluid blood density level demonstrated by Computerized Tomography in pituitary apoplexy. Report of two cases. J. Neurosurg. 55, 143 (1981).

    CAS  PubMed  Google Scholar 

  28. Gatti, E., Jato, E., Conconi, G.: L’apoplessia ipofisaria. Contributo anatomico-clinico. Folia endocrinol. 25, 480 (1971).

    Google Scholar 

  29. Gebel, P.: Pituitary apoplexy. Review of literature with a report of an unusual case associated with diabetes insipidus. Milit. Med. 127, 753 (1962).

    CAS  Google Scholar 

  30. Goebel, R., Leb, G., Weiss, P., Clarici, G., Warnkross, H., Biffl, H.: Die Wachstumshormonbestimmung mit einem kombinierten Stimulations test der Adenohypophyse. Manch. Med. Wschr. 119, 1450 (1977).

    Google Scholar 

  31. Green, J. D.: The comparative anatomy of the hypophysis, with special reference to its blood supply and innervation. Am. J. Anat. 88, 225 (1951).

    Article  CAS  PubMed  Google Scholar 

  32. Grumme, Th.: Hypophysenadenom mit apoplektischer Blutung. Zbl. Neurochir. 32, 187 (1971).

    CAS  Google Scholar 

  33. Guarnaschelli, J. J., Talalla, A.: Pituitary apoplexy. A case report. Bull. Los Angeles Neurol. Soc. 37, 12 (1972).

    CAS  PubMed  Google Scholar 

  34. Guiot, G., Derome, P.: Surgical problems in pituitary adenomas. In: Advances and technical standards in neurosurgery, Vol. 3. Springer, Wien New York 1976.

    Google Scholar 

  35. Gutin, P. H., Cushard, W. G., Wilson, C. B.: Cushing’s disease with pituitary apoplexy leading to hypopituitarysm, empty sella, and spontaneous fracture of the dorsum sellae. J. Neurosurg. 51, 866 (1979).

    CAS  PubMed  Google Scholar 

  36. Hardy, J.: Transsphenoidal hypophysectomy. J. Neurosurg. 34, 582 (1971).

    CAS  PubMed  Google Scholar 

  37. Hirano, A., Tomiyasu, U., Zimmermann, H. M.: The fine structure of blood vessels in chromophobe adenoma. Acta Neuropathol. (Berlin) 22, 200 (1972).

    Article  CAS  Google Scholar 

  38. Holness, R.O., Ogundimu, F. A., Langille, R. A.: Pituitary apoplexy following closed head trauma. J. Neurosurg. 59, 677 (1983).

    CAS  PubMed  Google Scholar 

  39. Jefferson, M., Rosenthal, F. D.: Spontaneous necrosis in pituitary tumors (pituitary apoplexy). Lancet I, 342 (1959).

    Article  Google Scholar 

  40. Jores, A., Nowakowski, H.: Praktische Endokrinologie. 4 Auflage. Thieme, Stuttgart 1976.

    Google Scholar 

  41. Kalyanaraman, U. P.: Clinically asymptomatic pituitary adenoma manifesting as pituitary apoplexy and fatal thiventricular hemorrhage. Hum. Pathol. 13, 1141 (1982).

    Article  CAS  PubMed  Google Scholar 

  42. Kaplan, B., Day, A. L., Quisling, R., Ballinger, W.: Hemorrhage into pituitary adenomas. Surg. Neurol. 20, 280 (1983).

    Article  CAS  PubMed  Google Scholar 

  43. Kosary, I. Z., Braham, J., Tadmor, R., Goldhammer, Y.: Transsphenoidal surgical approach in pituitary apoplexy. Neurochirurgia 19, 55 (1976).

    CAS  PubMed  Google Scholar 

  44. Labauge, R., Pages, A., Pages, M., Ribstein, J., Richard, J. L.: Necrose hemorragique d’un adenome hypophysaire polyoncose endocrinienne. Rev. Neurol., (Paris) 138, 149 (1982).

    CAS  Google Scholar 

  45. Landolt, A. M.: Ultrastructure of human sella tumors. Acta Neurochic. (Suppl. 22) 1975.

  46. Landolt, A. M.: Progress in pituitary adenoma biology. Results of research and clinical applications. In: Advances and technical standards in neurosurgery, Vol. 5. Springer, Wien-New York 1978.

    Google Scholar 

  47. Landolt, A. M., Strebel, P.: Technique of transsphenoidal operation for pituitary adenomas. In: Advances and technical standards in neurosurfiery, Vol. 7. Springer, Wien-New York 1980.

    Google Scholar 

  48. List, C. F., Williams, J. R., Balyeat, G. W.: Vascular lesions in pituitary adenomas. J. Neurosurg. 9, 177 (1952).

    CAS  PubMed  Google Scholar 

  49. Lawrence, A. M., Gordon, D. L., Hagen, T. C., Schwartz, M. A.: Hypothalamic hypopituitarism after pituitary apoplexy in acromegaly. Arch. intern. med. 137, 1134 (1977).

    Article  CAS  PubMed  Google Scholar 

  50. Laws, E. R., Ebersold, M. J.: Pituitary apoplexy — an endocrine emergency. World J. Surg. 6, 686 (1982).

    Article  PubMed  Google Scholar 

  51. Majchrzak, H., Wencel, T., Dragan, T., Bialas, J.: Acute hemorrhage into pituitary adenoma with SAH and anterior cerebral artery occlusion. Case report. J. Neurosurg. 58, 771 (1983).

    CAS  PubMed  Google Scholar 

  52. Miklyaeva, Y. I.: Pathomorphological changes of hypophysis in apoplexy and in softening of the tissue as a result of hypertensive vascular disease. Probl. endokrinol. (Moscow) 6, 34 (1960).

    Google Scholar 

  53. Mohanty, S., Tandon, P. N., Banerij, A. K., Prakash, B.: Hemorrhage into pituitary adenomas. J. Neurol. Neurosurg. Psychiatr. 40, 987 (1977).

    CAS  PubMed  Google Scholar 

  54. Mohr, G., Hardy, J.: Hemorrhage, necrosis, and apoplexy in pituitary adenomas. Surg. neurol. 18, 181 (1982).

    Article  CAS  PubMed  Google Scholar 

  55. Morello, G., Frera, C.: Visual damage after removal of hypophyseal adenomas: Possible importance of vascular disturbances of the optic nerves and chiasma. Acta Neurochir. 15, 1 (1966).

    Article  CAS  Google Scholar 

  56. Müller, W., Pia, H. W.: Zur Klinik and Atiologie der Massenblutungen in Hypophysenadenomen. Dtsch. Zeitschr. Nervenheilk. 170, 326 (1953).

    Google Scholar 

  57. MülIer-Jensen, A., Lüdecke, D.: Clinical aspects of spontaneous necrosis of pituitary tumors (pituitary apoplexy). J. neurol. 224, 267 (1981).

    Article  Google Scholar 

  58. Nadjmi, M., Piepgras, U., Vogelsang, H.: Kranielle Computertomographie. Ein synoptischer Atlas. Thieme, Stuttgart-New York 1981.

    Google Scholar 

  59. Patel, D. V., Shields, M. C.: Intraventricular hemorrhage in pituitary apoplexy. J. comput. assist. tomogr. 3, 829 (1979).

    CAS  PubMed  Google Scholar 

  60. Pelkonen, R., Kuusisto, A., Salmi, J., Eistola, P., Raitta, Ch., Karonen, S.-L., Aro, A.: Pituitary function after pituitary apoplexy. Am. J. Med. 65, 773 (1978).

    Article  CAS  PubMed  Google Scholar 

  61. Petersen, P., Lindholm, J.: Pituitary apoplexy, the Houssayphenomenon, and accelerated proliferative retinopathy. Am. Med. 79, 385 (1985).

    Article  CAS  Google Scholar 

  62. Post, M. J. D., David, N. J., Glaser, J. S., Safran, A.: Pituitary apoplexy: diagnosis by computed tomography. Radiology 134, 665 (1980).

    CAS  PubMed  Google Scholar 

  63. Raskind, R.: Pituitary apoplexy. JAMA 246, 834 (1981).

    Article  CAS  PubMed  Google Scholar 

  64. Rauhut, F., Clar, H. E.: Blutungen bei Hypophysentumoren and im Chiasmabereich - Eine dringliche Opera tionsindikation. Nervenarzt 53, 584 (1982).

    CAS  PubMed  Google Scholar 

  65. Ray, B. S., Patterson, R. H.: Surgical experience with chromophobe adenomas of the pituitary gland. J. Neurosurg. 34, 726 (1971).

    Article  CAS  PubMed  Google Scholar 

  66. Reid, R. L., Quigley, M. E., Yen, S. C.: Pituitary apoplexy. A review. Arch. Neurol. 42, 712 (1985).

    CAS  PubMed  Google Scholar 

  67. Reichenthal, E., Manor, R. S., Shalit, M. N.: Pituitary apoplexy during carotid angiography. Acta Neurochir. 54, 251 (1980).

    Article  CAS  Google Scholar 

  68. Robinson, J. L., Chir, B.: Sudden blindness with pituitary tumors. J. Neurosurg. 36, 83 (1972).

    CAS  PubMed  Google Scholar 

  69. Rosenbaum, T. J., Houser, O. W., Laws, E. R.: Pituitary apoplexy produring internal carotid artery occlusion. Case report. J. Neurosurg. 47, 599 (1977).

    CAS  PubMed  Google Scholar 

  70. Röttgen, P., Peters, G.: Über “Massenblutungen” in Hypophysenade nome. Zbl. Neurochir. 12, 65 (1952).

    Google Scholar 

  71. Rovit, R. L., Fein, J. M.: Pituitary apoplexy: a review and reappraisal. J. Neurosurg. 37, 280 (1972).

    CAS  PubMed  Google Scholar 

  72. Rushworth, R. G.: Pituitary apoplexy. Med. J. Aust. 1, 251 (1971).

    CAS  PubMed  Google Scholar 

  73. Sakalas, R., David, R. B., Vines, F. S., Becker, D.P.: Pituitary apoplexy in a child. Casereport. J. Neurosurg. 39, 519 (1973).

    Article  CAS  PubMed  Google Scholar 

  74. Sanchis, J., Bordes, M.: Immediate visual deterioration after attempts at radical excision of pituitary adenomas. Acta Neurochir. 38, 251 (1977).

    Article  CAS  Google Scholar 

  75. Scharfetter, F.: Plötzliche Erblindung durch Blutung in eine Hypophysengeschwulst. Schweiz. Arch. Neurol. Neurochir. Psychiatr. 114, 95 (1974).

    CAS  Google Scholar 

  76. Sehechter, J.: Ultrastructural changes in the capillary bed of human pituitary tumors. Am. J. pathol. 67, 109 (1972).

    Google Scholar 

  77. Schneider, G. H.: CT-findings in pituitary adenomas. In: Prolactinomas. An interdisciplinary approach. Eds. L. M. Auer, G. Leb, G. Tscherne, W. Urdl, G. F. Walter, p. 91. Walter de Gruyter, Berlin-New York 1985.

    Google Scholar 

  78. Schneider, G. H., Steiner, H., Ladurner, G., Clarici, G.: CT findings in pituitary tumors with emphasis on pituitary adenomas. In: Neuroimaging. Eds. Gerstenbrand, Grecevic, Aigner. Gustav Fischer, Stuttgart-New York 1985.

    Google Scholar 

  79. Sheehan, H. L.: Post-partum necrosis of the anterior pituitary. J. pathol. bacteriol. 45, 189 (1937).

    Article  CAS  Google Scholar 

  80. Shenkin, H. A.: Relief of ambliopia in pituitary apoplexy by prompt surgical intervention. JAMA 159, 1622 (1955).

    CAS  Google Scholar 

  81. Slavin, M. L., Budabin, M.: Pituitary apoplexy associated with cardiac surgery. Am. J. Ophthalmol. 98, 291 (1984).

    CAS  PubMed  Google Scholar 

  82. Spatz, R., Jordan, H.: Apoplektiforme Blutungen in Hypophysentumoren. Munch. Med. Wschr. 115, 2021 (1973).

    CAS  PubMed  Google Scholar 

  83. Symon, L., Mohanty, S.: Hemorrhage in pituitary tumors. Acta Neurochir. 65, 41 (1982).

    Article  CAS  Google Scholar 

  84. Udvarhelyi, G. B., Walsh, F. B.: Complications involving the optic nerves and chiasm during the early period after neurosurgical operations. J. Neurosurg. 19, 51 (1962).

    CAS  PubMed  Google Scholar 

  85. Uihlein, A., Balfour, W. M., Donovan, P. F.: Acute hemorrhage into pituitary adenomas. J. Neurosurg. 14, 140 (1957).

    CAS  PubMed  Google Scholar 

  86. Urdl, W., Tscherne, G., Auer, L. M., Clarici, G., Leb, G., Warnkross, H.: Pregnancies after treatment of prolactinomas: course and complications. In: Prolactinomas. An interdisciplinary approach. Eds. L. M. Auer, G. Leb, G. Tscherne, W. Urdl, G. F. Walter, p. 417. Walter de Gruyter, Berlin-New York 1985.

    Google Scholar 

  87. Van Wagenen, W. P.: Hemorrhage into a pituitary tumor following trauma. Am. surg. 95, 625 (1932).

    Google Scholar 

  88. Wakai, S., Fukushima, T., Teramoto, A., Sano, K.: Pituitary apoplexy: its incidence and clinical significance. J. Neurosurg. 55, 187 (1981).

    CAS  PubMed  Google Scholar 

  89. Weiss, M. H., Apuzzo, M. L., Heiden, J. S., Kurze, T.: Pituitary apoplexy, therapeutic assessment. Bull. Los Angeles Neurol. Soc. 41, 143 (1976).

    CAS  PubMed  Google Scholar 

  90. Welch, K., Stears, J. C.: Chiasmapexy for the correction of traction on the optic nerves and chiasm associated with their descent into an empty sella turcica. J. Neurosurg. 35, 760 (1971).

    CAS  PubMed  Google Scholar 

  91. Williams, F. W.: Pituitary necrosis in a diabetic during pregnancy: The Houssay phenomenon in men. Diabetes 1, 37 (1952).

    CAS  PubMed  Google Scholar 

  92. Zambrano, D., Amezua, L., Dickmann, G., Franke, E.: Ultrastructure of human pituitary adenomaa. Acta Neurochir. 18, 78 (1968).

    Article  Google Scholar 

  93. Zervas, N. T., Mendelson, G.: Treatment of acute hemorrhage of pituitary tumors. Lancet I, 604 (1975).

    Article  Google Scholar 

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Clarici, G. Dringliche Hypophysenchirurgie. Acta Chir Austriaca 19, 615–625 (1987). https://doi.org/10.1007/BF02745356

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