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Brain GABAA receptors studied with subunit-specific antibodies

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Abstract

Brain GABAA/benzodiazepine receptors are highly heterogeneous. This heterogeneity is largely derived from the existence of many pentameric combinations of at least 16 different subunits that are differentially expressed in various brain regions and cell types. This molecular heterogeneity leads to binding differences for various ligands, such as GABA agonists and antagonists, benzodiazepine agonists, antagonists, and inverse agonists, steroids, barbiturates, ethanol, and Cl− channel blockers. Different subunit composition also leads to heterogeneity in the properties of the Cl− channel (such as conductance and open time); the allosteric interactions among subunits; and signal transduction efficacy between ligand binding and Cl− channel opening. The study of recombinant receptors expressed in heterologous systems has been very useful for understanding the functional roles of the different GABAA receptor subunits and the relationships between subunit composition, ligand binding, and Cl− channel properties. Nevertheless, little is known about the complete subunit composition of the native GABAA receptors expressed in various brain regions and cell types. Several laboratories, including ours, are using subunit-specific antibodies for dissecting the heterogeneity and subunit composition of native (not reconstituted) brain GABAA receptors and for revealing the cellular and subcellular distribution of these subunits in the nervous system. These studies are also aimed at understanding the ligand-binding, transduction mechanisms, and channel properties of the various brain GABAA receptors in relation to synaptic mechanisms and brain function. These studies could be relevant for the discovery and design of new drugs that are selective for some GABAA receptors and that have fewer side effects.

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References

  1. Baude A., Sequier J. M., McKernan R. M., Olivier K. R., and Somogyi P. (1992)Neuroscience 51, 739–748.

    Article  PubMed  CAS  Google Scholar 

  2. Fritschy J.-M., Benke D., Mertens S., Oertel W. H., Bachi T., and Möhler H. (1992)Proc. Natl. Acad. Sci. USA 89, 6726–6730.

    Article  PubMed  CAS  Google Scholar 

  3. Santi M. R., Vicini S., Eldadah B., and Neale J. (1994)J. Neurochem. 63, 2357–2360.

    Article  PubMed  CAS  Google Scholar 

  4. Nayeem N., Green T. P., Martin I. L., and Barnard E. A. (1994)J. Neurochem. 62, 815–818.

    Article  PubMed  CAS  Google Scholar 

  5. Olsen R. W. and Tobin A. J. (1990)FASEB J. 4, 1469–1480.

    PubMed  CAS  Google Scholar 

  6. Burt D. and Kamatchi G. L. (1991)FASEB J. 5, 2916–2923.

    PubMed  CAS  Google Scholar 

  7. Dunn S. M. J., Bateson A. N., and Martin I. L. (1994)Int. Rev. Neurobiol. 36, 51–96.

    PubMed  CAS  Google Scholar 

  8. Macdonald R. L. and Olsen R. W. (1994)Ann. Rev. Neurosci 17, 569–602.

    PubMed  CAS  Google Scholar 

  9. Lüddens H., Korpi E. R., and Seeburg P. H. (1995)Neuropharmacology 34, 245–254.

    Article  PubMed  Google Scholar 

  10. Laurie D. J., Seeburg P. H., and Wisden W. (1992)J. Neurosci. 12, 1063–1076.

    PubMed  CAS  Google Scholar 

  11. Persohn E., Malherble P., and Richards J. G. (1992)J. Comp. Neurol. 326, 193–216.

    Article  PubMed  CAS  Google Scholar 

  12. Wisden W., Laurie D. J., Monyer H., and Seeburg P. H. (1992)J. Neurosci. 12, 1040–1062.

    PubMed  CAS  Google Scholar 

  13. Miralles C. P., Gutiérrez A., Khan Z. U., Vitorica J., and De Blas A. L. (1994)Mol. Brain Res. 24, 129–139.

    Article  PubMed  CAS  Google Scholar 

  14. Schofield P. R., Darlison M. G., Fujita M., Burt D. R., Stephenson F. A., Rodriguez H., Rhee L. M., Ramachlandran J., Reale V., Glencorse T. A., Seeburg P. H., and Barnard E. A. (1987)Nature 328, 221–227.

    Article  PubMed  CAS  Google Scholar 

  15. Cutting G. R., Lu L., O'hara B. F., Kasch L. M., Montrose Rafidadeh C., Donovan D. M., Shirnada S., Antonarakis S. E., Guggino W. B., Uhl G. R., and Kazazian H. H. (1991)Proc. Natl. Acad. Sci. USA 88, 2673–2677.

    Article  PubMed  CAS  Google Scholar 

  16. Whiting P., McKernan R. M., and Iversen L. L. (1990)Proc. Natl. Acad. Sci. USA 87, 9966–9970.

    Article  PubMed  CAS  Google Scholar 

  17. Kofuji P., Wang J. B., Moss S. J., Huganir R. L., and Burt D. R. (1991)J. Neurochem. 56, 713–715.

    Article  PubMed  CAS  Google Scholar 

  18. Kirkness E. F. and Fraser C. M. (1993)J. Biol. Chem. 268, 4420–4428.

    PubMed  CAS  Google Scholar 

  19. Korpi E. R., Kuner R., Kristo P., Köhler M., Herb A., Lüddens H., and Seeburg P. H. (1994)J. Neurochem. 63, 1167–1170.

    Article  PubMed  CAS  Google Scholar 

  20. Bateson A. N., Lasham A., and Darlison M. G. (1991)J. Neurochem. 56, 1437–1440.

    Article  PubMed  CAS  Google Scholar 

  21. Harvey R. J., Chinchetru M. A., and Darlison M. G. (1994)J. Neurochem. 62, 10–16.

    Article  PubMed  CAS  Google Scholar 

  22. Harvey R. J., Kim H.-C., and Darlison M. G. (1994)FEBS Lett. 331, 211–216.

    Article  Google Scholar 

  23. Vitorica J., Park D., Chin G., and De Blas A. L. (1990)J. Neurochem. 54, 187–194.

    Article  PubMed  CAS  Google Scholar 

  24. Ruano D., Benavides J., Machado A., and Vitorica J. (1995)J. Neurochem. 64, 225–233.

    Google Scholar 

  25. Sieghart W. and Karobath M. (1980)Nature 286, 285–287.

    Article  PubMed  CAS  Google Scholar 

  26. Sieghart W. and Drexler G. (1983)J. Neurochem..41, 47–55.

    Article  PubMed  CAS  Google Scholar 

  27. Eichinger A. and Sieghart W. (1986)J. Neurochem. 46, 173–180.

    Article  PubMed  CAS  Google Scholar 

  28. Lüddens H., Pritchett D. B., Köhler M., Killisch I., Keinänen K., Monyer H., Sprengel R., and Seeburg P. H. (1990)Nature 346, 648–651.

    Article  PubMed  Google Scholar 

  29. Turner D. M., Sapp D. W., and Olsen R. W. (1991)J. Pharmacol. Exp. Ther. 257, 1236–1242.

    PubMed  CAS  Google Scholar 

  30. Uusi Oukari M. (1992)J. Neurochem. 59, 568–574.

    Article  PubMed  CAS  Google Scholar 

  31. Wong G., Sei Y., and Skolnick P. (1992)Mol. Pharmacol. 42, 996–1003.

    PubMed  CAS  Google Scholar 

  32. Khan Z., Fernando L., Escriba P., Busquets X., Mallet J., Miralles C., Filla M., and De Blas A. L. (1993)J. Neurochem. 60, 961–971.

    Article  PubMed  CAS  Google Scholar 

  33. Wieland H. A. and Lüddens H. (1994)J. Med. Chem. 37, 4576–4580.

    Article  PubMed  CAS  Google Scholar 

  34. Khan, Z. U., Gutiérrez A., and De Blas A. L. (1994)J. Neurochem. 63, 371–374.

    Article  PubMed  CAS  Google Scholar 

  35. Khan Z. U., Gutiérrez A., and De Blas A. L. (1996)J. Neurochem. 66, 685–691.

    Article  PubMed  CAS  Google Scholar 

  36. Sigel E., Stephenson F. A., Mamalaki C., and Barnard E. A. (1983)J. Biol. Chem. 258, 6965–6971.

    PubMed  CAS  Google Scholar 

  37. Vitorica J., Park D., Chin G., and De Blas A. L. (1988)J. Neurosci 8, 615–622.

    PubMed  CAS  Google Scholar 

  38. Taguchi J.-I. and Kuriyama K. (1984)Brain Res. 323, 219–226.

    Article  PubMed  CAS  Google Scholar 

  39. Park D., Vitorica J., Tous G., and De Blas A. L. (1991)J. Neurochem. 56, 1962–1971.

    Article  PubMed  CAS  Google Scholar 

  40. Park D. and De Blas A. L. (1991).J. Neurochem. 56, 1972–1979.

    Article  PubMed  CAS  Google Scholar 

  41. Park D. and De Blas A. L. (1991)Brain Res. 550, 279–286.

    Article  PubMed  CAS  Google Scholar 

  42. Häring P., Stähli C., Schoch P., Takács B., Staehelin T., and Möhler H. (1985)Proc. Natl. Acad. Sci. USA 82, 4837–4841.

    Article  PubMed  Google Scholar 

  43. Vitorica J., Park D., and De Blas A. L. (1987)Eur. J. Pharmacol. 136, 451–453.

    Article  PubMed  CAS  Google Scholar 

  44. Sweetnam P. M., Nestler E., Gallombardo P., Brown S., Duman R., Bracha H. S., and Tallman J. (1987)Mol. Brain. Res. 2, 223–233.

    Article  CAS  Google Scholar 

  45. De Blas A. L., Vitorica J., and Friedrich P. (1988)J. Neurosci. 8, 602–614.

    PubMed  Google Scholar 

  46. Richards J. G., Schoch P., Haring P., Takács B., and Möhler H. (1987)J. Neurosci. 7, 1866–1886.

    PubMed  CAS  Google Scholar 

  47. Ewert M., Shivers B., Lüddens H., Möhler H., and Seeburg P. (1990)J. Cell Biol. 110, 2043–2048.

    Article  PubMed  CAS  Google Scholar 

  48. Ewert M., De Blas A. L., Möhler H., and Seeburg P. H. (1992)Brain Res. 569, 57–62.

    Article  PubMed  CAS  Google Scholar 

  49. Fernando L. P., Khan Z. U., McKernan R. M., and De Blas A. L. (1995)J. Neurochem. 64, 1305–1311.

    Article  PubMed  CAS  Google Scholar 

  50. Gutiérrez A., Khan Z. U., and De Blas A. L. (1994)J. Neurosci. 14, 7168–7179.

    PubMed  Google Scholar 

  51. Gutiérrez A., Khan Z. U., Morris S. J., and De Blas A. L. (1994)J. Neurosci. 14, 7469–7477.

    PubMed  Google Scholar 

  52. Gutiérrez A., Khan Z. U., Miralles C. P., and De Blas A. L. (1996)Mol. Brain Res. 35, 91–102.

    Article  PubMed  Google Scholar 

  53. Gutiérrez A., Khan Z. U., and De Blas A. L. (1996)J. Comp. Neurol. 365, 504–510.

    Article  PubMed  Google Scholar 

  54. Khan Z. U., Gutiérrez A., and De Blas A. L. (1994)J. Neurochem. 63, 1466–1476.

    Article  PubMed  CAS  Google Scholar 

  55. Kirkness E. F. and Turner A. J. (1988)Biochem. J. 256, 291–294.

    PubMed  CAS  Google Scholar 

  56. Sato T. N. and Neal J. H. (1989)J. Neurochem. 53, 1089–1095.

    Article  PubMed  CAS  Google Scholar 

  57. Fuch K., Adamiker D., and Sieghart W. (1990)FEBS Lett. 261, 52–54.

    Article  Google Scholar 

  58. Stephenson F. A., Duggan M. J., and Pollard S. (1990)J. Biol. Chem. 265, 21,160–21,165.

    CAS  Google Scholar 

  59. Benke D., Mertens S., Trzeciak A., Gillessen, D., and Möhler H. (1991)J. Biol. Chem. 266, 4478–4483.

    PubMed  CAS  Google Scholar 

  60. Benke D., Mertens S., Trzeciak A., Gillessen D., and Möhler H. (1991)FEBS Lett. 283, 145–149.

    Article  PubMed  CAS  Google Scholar 

  61. Duggan M. J., Pollard S., and Stephenson F. A. (1991)J. Biol. Chem. 266, 24,778–24,784.

    CAS  Google Scholar 

  62. Endo S. and Olsen R. (1992)J. Neurochem. 59, 1444–1451.

    Article  PubMed  CAS  Google Scholar 

  63. Endo S. and Olsen R. W. (1993)J. Neurochem. 60, 1388–1398.

    Article  PubMed  CAS  Google Scholar 

  64. Thompson C. L., Bodewitz G., Stephenson F. A., and Turner T. D. (1992)Neurosci Lett. 144, 53–56.

    Article  PubMed  CAS  Google Scholar 

  65. Mertens S., Benke D., and Möhler H. (1993)J. Biol. Chem. 268, 5965–5973.

    PubMed  CAS  Google Scholar 

  66. Benke D., Fritschy J.-M., Trzeciak A., Bannwarth W., and Möhler H. (1994)J. Biol. Chem. 269, 27,100–27,107.

    CAS  Google Scholar 

  67. Kern W. and Sieghart W. (1994)J. Neurochem. 62, 764–769.

    Article  PubMed  CAS  Google Scholar 

  68. Mossier B., Tögel M., Fuch K., and Sieghart W. (1994)J. Biol. Chem. 269, 25,777–25,782.

    CAS  Google Scholar 

  69. Nadler L. S., Guirguis E. R., and Siegel, R. E. (1994)J. Neurobiol. 25, 1533–1544.

    Article  PubMed  CAS  Google Scholar 

  70. Tögel M., Mossier B., Fuch K., and Sieghart W. (1994)J. Biol. Chem. 269, 12,993–12,998.

    Google Scholar 

  71. Moreno J. I., Piva M. A., Miralles C. P., and De Blas A. L. (1994)J. Comp. Neurol. 350, 260–271.

    Article  PubMed  CAS  Google Scholar 

  72. Fernando L. P., Khan Z. U., and De Blas A. L. (1995)Mol. Brain Res. 28, 94–100.

    Article  PubMed  CAS  Google Scholar 

  73. McKernan R. M., Quirk K., Prince R., Cox P. A., Gillard N. P., Ragan C. I., and Whiting P. (1991)Neuron 7, 667–676.

    Article  PubMed  CAS  Google Scholar 

  74. Moss S. J., Smart T. G., Blackstone C. D., and Huganir R. L. (1992)Science 257, 661–665.

    Article  PubMed  CAS  Google Scholar 

  75. Quirk K., Guillard N. P., Ragan C. I., Whiting P. J., and McKernan R. M. (1994)J. Biol. Chem. 269, 16,020–16,028.

    CAS  Google Scholar 

  76. Quirk K., Gillard N. P., Ragan C. I., Whiting P. J., and McKernan R. M. (1994)Mol. Pharmacol. 45, 1061–1070.

    PubMed  CAS  Google Scholar 

  77. Hughes T. E., Carey R. G., Vitorica J., De Blas A. L., and Karten H. (1989)Vis. Neurosci. 2, 565–581.

    Article  PubMed  CAS  Google Scholar 

  78. Juiz J. M., Helfert R. H., Wenthold R. J., De Blas A. L., and Altschuler R. A. (1989)Brain Res. 504, 173–179.

    Article  PubMed  CAS  Google Scholar 

  79. Somogyi P. (1989) inNeural Mechanisms of Visual Perception (Lam D. K.-T. and Gilbert C. D., eds.), Portfolio, TX, pp. 35–62.

  80. Yazulla S., Studholme K. M., Vitorica J., and De Blas A. L. (1989)J. Comp. Neurol. 280, 15–26.

    Article  PubMed  CAS  Google Scholar 

  81. Meinecke D. L. and Rakic P. (1992).J. Comp. Neurol. 317, 91–101.

    Article  PubMed  CAS  Google Scholar 

  82. Hendry S. H. C., Fuchs J., De Blas A. L., and Jones E. G. (1990)J. Neurosci.,10, 2438–2450.

    PubMed  CAS  Google Scholar 

  83. Hendry S. H. C., Huntsman M.-M., Viñuelas A., Möhler H., De Blas A. L., and Jones E. G. (1994)J. Neurosci. 14, 2383–2401.

    PubMed  CAS  Google Scholar 

  84. Huntley G. W., De Blas A. L., and Jones E. G. (1990)Exp. Brain Res. 82, 519–535.

    Article  PubMed  CAS  Google Scholar 

  85. Spreafico R., De Biasi S., Amadeo A., and De Blas A. L. (1993)Neurosci. Lett. 158, 232–236.

    Article  PubMed  CAS  Google Scholar 

  86. Spreafico R., Mennini T., Danober L., Cagnotto A., Regondi M. C., Miari A., De Blas A. L., Vergnes M., and Avanzini G. (1993)Epilepsy Res. 15, 229–238.

    Article  PubMed  CAS  Google Scholar 

  87. Cobas A., Fairén A., Alvarez-Bolado G., and Sánchez M. P. (1991)Neuroscience 40, 375–397.

    Article  PubMed  CAS  Google Scholar 

  88. Bentvoglio M., Spreafico R., Alvarez-Bolado G., Sánchez M. P., and Fairén A. (1991)Eur. J. Neurosci. 3, 118–125.

    Article  Google Scholar 

  89. Somogyi P., Takagi H., Richards J. G., and Möhler H. (1989)J. Neurosci. 9, 2197–2209.

    PubMed  CAS  Google Scholar 

  90. Nusser Z., Roberts J. D. B., Baude A., Richards J. G., and Somogyi P. (1995)J. Neurosci. 15, 2948–2960.

    PubMed  CAS  Google Scholar 

  91. Fritschy J.-M., Paysan J., Enna A., and Möhler H. (1994)J. Neurosci. 14, 5302–5324.

    PubMed  CAS  Google Scholar 

  92. Zimprich F., Zezula J., Sieghart W., and Lassmann H. (1991)Neurosci. Lett. 127, 125–128.

    Article  PubMed  CAS  Google Scholar 

  93. Araki T., Kiyama H., Maeno H., and Tohyama M. (1993)Mol. Brain Res. 20, 263–266.

    Article  PubMed  CAS  Google Scholar 

  94. Gu Q., Perez-Velazquez J. L., Angelides K. J. and Cynader M. S. (1993)J. Comp. Neurol. 333, 94–108.

    Article  PubMed  CAS  Google Scholar 

  95. Turner J. D., Bodewitz G., Thompson C. L., and Stephenson F. A. (1993)Psychopharmacol. Ser. 11, 29–49.

    PubMed  CAS  Google Scholar 

  96. Paysan J., Bolz J., Möhler H., and Fritschy J.-M. (1994)J. Comp. Neurol. 350, 133–149.

    Article  PubMed  CAS  Google Scholar 

  97. Thompson C. L. and Stephenson F. A. (1994)J. Neurochem. 62, 2037–2044.

    Article  PubMed  CAS  Google Scholar 

  98. Gao B., Fritschy J.-M., Benke D., and Möhler H. (1993)Neuroscience 54, 881–892.

    Article  PubMed  CAS  Google Scholar 

  99. Gao B. and Fritschy J.-M. (1994)Eur. J. Neurosci. 6, 837–853.

    Article  PubMed  CAS  Google Scholar 

  100. Caruncho H. J. and Costa E. (1994)Recep. Chan. 2, 143–153.

    CAS  Google Scholar 

  101. Pollard S., Duggan M. J., and Stephenson F. A. (1991)FEBS Lett. 295, 81–83.

    Article  PubMed  CAS  Google Scholar 

  102. Buchstaller A., Adannike D., Fuch K., and Sieghart W. (1991)FEBS Lett. 287, 27–30.

    Article  PubMed  CAS  Google Scholar 

  103. Machu T., Olsen R., and Browning M. (1993)J. Neurochem. 61, 2034–2040.

    Article  PubMed  CAS  Google Scholar 

  104. Duggan M. J., Pollard S., and Stephenson F. A. (1992)J. Neurochem. 58, 72–77.

    Article  PubMed  CAS  Google Scholar 

  105. Sigel E., Baur R., Trube G., Möhler H., Malherbe P. (1990)Neuron 5, 703–711.

    Article  PubMed  CAS  Google Scholar 

  106. Amin J. and Weiss D. S. (1993)Nature 366, 565–569.

    Article  PubMed  CAS  Google Scholar 

  107. Smith G. B. and Olsen R. W. (1994)J. Biol. Chem. 269, 20,380–20,387.

    CAS  Google Scholar 

  108. Pritchett D. B., Sontheimer H., Shivers B. D., Ymer S., Kettenmann H., Schofield P. R., and Seeburg P. H. (1989)Nature 338, 582–585.

    Article  PubMed  CAS  Google Scholar 

  109. Pritchett D. B. and Seeburg P. H. (1991)Proc. Natl. Acad. Sci. USA 88, 1421–1425.

    Article  PubMed  CAS  Google Scholar 

  110. Verdoorn T. A., Draguhn A., Ymer S., Seeburg P. H., and Sakmann B. (1990)Neuron 4, 919–928.

    Article  PubMed  CAS  Google Scholar 

  111. Korpi E. R. and Lüddens H. (1993)Mol. Pharmacol. 44, 63–68.

    Google Scholar 

  112. Mihic S. J., Whiting P. J., Klein R. L., Wafford K. A., and Harris R. A. (1994)J. Biol. Chem. 269, 32,768–32,773.

    CAS  Google Scholar 

  113. Wong G. and Skolnick P. (1992)Eur. J. Pharmacol. 225, 63–68.

    Article  PubMed  CAS  Google Scholar 

  114. Im H. K., Im W. B., Hamilton B. J., Carter D. B., Vonvoigtlander P. F. (1993)Mol. Pharmacol. 44, 866–870.

    PubMed  CAS  Google Scholar 

  115. Herb A., Wisden W., Lüddens H., Puia G., Vicini S., and Seeburg P. (1992)Proc. Natl. Acad. Sci. USA 89, 1433–1437.

    Article  PubMed  CAS  Google Scholar 

  116. Ymer S., Draguhn A., Wisden W., Werner P., Keinänen K., Schofield P. R., Sprengel R., Pritchett D.B., and Seeburg P.H. (1990)EMBO J. 9, 3261–3267.

    PubMed  CAS  Google Scholar 

  117. Pritchett D. B., Lüddens H., and Seeburg P. (1989)Science 245, 1389–1392.

    Article  PubMed  CAS  Google Scholar 

  118. Zezula J. and Sieghart W. (1991)FEBS Lett. 284, 15–18.

    Article  PubMed  CAS  Google Scholar 

  119. Ruano D., Khan Z., De Blas A. L., Machado A., and Vitorica J. (1994)Eur. J. Pharmacol. 267, 123–128.

    Article  PubMed  CAS  Google Scholar 

  120. Ruano D., Araujo F., Machado A., De Blas A. L., and Vitorica J. (1994)Mol. Brain Res. 25, 225–233.

    Article  PubMed  CAS  Google Scholar 

  121. Pritchett D. B. and Seeburg P. H. (1990)J. Neurochem. 54, 1802–1804.

    Article  PubMed  CAS  Google Scholar 

  122. Wieland H. A., Lüddens H., and Seeburg P. H. (1992)J. Biol. Chem. 267, 1426–1429.

    PubMed  CAS  Google Scholar 

  123. Ebert B., Wafford K. A., Whiting P. J., Krogsguard-Larsen P., and Kemp J. A. (1994)Mol. Pharmacol. 46, 957–963.

    PubMed  CAS  Google Scholar 

  124. Pollard S., Duggan M. J., and Stephenson F. A. (1993)J. Biol. Chem. 268, 3753–3757.

    PubMed  CAS  Google Scholar 

  125. Lüddens H., Killisch I., and Seeburg P. (1991)J. Rec. Res. 11, 535–551.

    Google Scholar 

  126. Verdoorn T. A. (1994)Mol. Pharmacol. 45, 475–480.

    PubMed  CAS  Google Scholar 

  127. Backus K. H., Arigoni M., Drescher U., Scheurer L., Malherbe P., Möhler H., and Benson J. A. (1993)NeuroReport 5, 285–288.

    Article  PubMed  CAS  Google Scholar 

  128. Sigel E., Baur R., Kellenberger S., and Malherbe P. (1992)EMBO J. 11, 2017–2023.

    PubMed  CAS  Google Scholar 

  129. Khan Z. U., Gutiérrez A., Miralles C. P., and De Blas A. L. (1996)Neurochem. Res., in press.

  130. Stephenson F. A. (1995)Biochem. J. 310, 1–9.

    PubMed  CAS  Google Scholar 

  131. Galzi J.-L. and Changeux J.-P. (1994)Curr. Opin. Struct. Biol. 4, 554–565.

    Article  CAS  Google Scholar 

  132. Fritschy J.-M. and Möhler H. (1995)J. Comp. Neurol. 359, 154–194.

    Article  PubMed  CAS  Google Scholar 

  133. Nusser Z., Roberts J. D. B., Baude A., Richards, J. G., Sieghart W., and Somogyi P. (1995)Eur. J. Neurosci 7, 630–646.

    Article  PubMed  CAS  Google Scholar 

  134. Smith G. B. and Olsen R. W. (1995)TIPS 16, 162–168.

    PubMed  CAS  Google Scholar 

  135. Günther U., Benson J., Benke D., Fristchy J.-M., Reyes G., Knoflach F., Crestani F., Aguzzi A., Arigoni M., Lang Y., Bluethmann H., Möhler H., and Lüscher B. (1995)Proc. Natl. Acad. Sci. USA 92, 7749–7753.

    Article  PubMed  Google Scholar 

  136. Wisden W., Herb A., Wieland H., Keinänen K., Lüddens H., and Seeburg P. H. (1991)FEBS Lett. 289, 227–230.

    Article  PubMed  CAS  Google Scholar 

  137. Lüddens H., Seeburg P. H., and Korpi E. R. (1994).Mol. Pharmacol. 45, 810–814.

    PubMed  Google Scholar 

  138. Benke D., Mertens S., and Möhler H. (1991)Mol. Neuropharmacol. 1, 103–110.

    CAS  Google Scholar 

  139. Wafford K. A., Bain C. J., Whiting P. J., and Kemp J. A. (1993)Mol. Pharmacol. 44, 437–442.

    PubMed  CAS  Google Scholar 

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  1. Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, 5100 Rockhill Road, 64110-2499, Kansas City, MO

    Angel L. De Blas

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De Blas, A.L. Brain GABAA receptors studied with subunit-specific antibodies. Mol Neurobiol 12, 55–71 (1996). https://doi.org/10.1007/BF02740747

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