Abstract
Changes in the activity of hexokinase and lactate dehydrogenase isoenzymes in the three brain regions and heart were studied in the 6-Aminonicotinamide-treated rats. Drug administration decreased the particulate hexokinase and lactate dehydrogenase activity, but increased the soluble hexokinase
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Abbreviations
- 6-AN:
-
6-Aminonicotinamide
- TPF:
-
total particulate fraction
References
Ammon, H. P. T. and Steinke, J. (1972)Diabetes,21, 143.
Bergmeyer, H. U. and Bernt, E. (1974) Methods inEnzymatic Analysis (ed. H. U. Bergmeyer) (New York: Academic Press) Vol. 2, p. 574.
Copley, M. and Fromm, H. J. (1967)Biochemistry,6, 3503.
Grossbard, L. and Schimke, R. T. (1966)J. Biol. Chem.,24, 3546.
Gumaa, K. and McLean, P. (1972)FEBS Lett:27, 293.
Herken, H. (1968b)Arzneim. Forsch.,18, 1234.
Herken, H., Lange, K., Kolbe, H. and Kelloer, K. (1974) inCentral Nervous System-studies on metabolite regulation and function (eds E. Genazzani and H. Herken) (Berlin-Heidelberg, New York: Springer) p. 41.
Hothersall, J. S., Zubairu, S., McLean, P. and Greenbaum, A. L. (1981)J. Neurochem.,37, 1484.
Kaur, G., Singh, R. and Baquer, N. Z. (1983)J. Neurochem.,41, 594.
Lange, K., Kolbe, H. and Herken, H. (1970)Z. Physiol. Chem.,351, 1241.
Ornstein, L. (1964)Ann. N Y. Acad. Sci.,121, 321.
Sharma, C., Manjeshwar, R. and Weinhouse, S. (1963)J. Biol. Chem.,238, 3840.
Sternberg, S. S. and Phillips, F. S. (1959)Bull. N. Y. Acad. Med.,35, 811.
Wilson, J. E. (1980) inCurrent Topics in Cell Regulation (eds B. L. Horecker, and E. R. Stadtman) (New York: Academic Press) Vol. 16, p. 1.
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Kaur, G., Singh, R. & Baquer, N.Z. Effect of 6-Aminonicotinamide on the activity of hexokinase and lactate dehydrogenase isoenzymes in regions of the rat brain. J Biosci 6, 331–336 (1984). https://doi.org/10.1007/BF02716748
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DOI: https://doi.org/10.1007/BF02716748