Abstract
A method was developed for the analysis of99mTc MAA perfusion and99mTc phytate colloid aerosol inhalation distribution patterns. Scintigraphic images were compared, based on the activity of corresponding picture elements (pixels). The possible mismatching in a pixel between both distributions was expressed in terms of a regional mismatching (common to a whole region) and an additional intraregional mismatching at the individual pixel level. Parameters characterizing the degree of regional and intraregional mismatching were introduced. The method was applied to 16 anesthetized healthy dogs in which a cranial-to-caudal gradient in regional mismatching was found.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Agnew JE, Bateman JRM, Pavia D, Clarke SW (1984) Radionuclide demonstration of ventilatory abnormalities in mild asthma. Clin Science 66:525–531
Amis TC, Jones HA, Rhodes CG, Heather JD, Hughes JMB (1982) Regional distribution of pulmonary ventilation and perfusion in the conscious dog. Am J Vet Res 43:1972–1977
Bake BL, Murphy B, Macklem PT, Milic-Emili J (1974) Effect of inspiratory flow rate on regional distribution of inspired gas. J Appl Physiol 37:8–17
Burton GH, Vernon P, and Seed WA (1984) An automated quantitative analysis of ventilation-perfusion lung scintigrams. J Nucl Med 25:564–570
Dowsett DJ, Kenny PA, Ennis JT (1985) Computer image substraction gives separate lung perfusion and ventilation images using99mTc-MAA and DTPA aerosol. European Nuclear Medicine Congress, London
Edmunds LH, Gold WM, Heymann MA (1970) Lobar distribution of pulmonal arterial blood flow in awake standing dogs. Am J Physiol 219:1779–1783
Emmet PC, Love RG, Hannan WJ, Millar, AM, and Soutar CA (1984) The relationship between the pulmonary distribution of inhaled fine aerosol and tests of small airway function. Bull Eur Physiopathol Respir 20:325–332
Fazio F, Wollmer P, Lavender JP, Barr MM (1982) Clinical ventilation imaging with In-113m: a comparison with Kr-81m. J Nucl Med 23:306–314
Francis RA, Agnew JE, Sutton PP, Pavia D, Clarke SW (1981) Ventilation imaging with easily prepared99mTc aerosols. Nucl Med Commun 2:203–208
Garg A, Copinath PG, Pande JN, Guleria JS (1983) Role of radioaerosol and perfusion lung imaging in early detection of chronic obstructive lung disease. Eur J Nucl Med 8:167–171
Greening AP, Miniati M, Fazio F (1980) Regional deposition of aerosols in health and in airways obstruction: a comparison with krypton-81m ventilation scanning. Bull Eur Physiopathol Respir 16:287–298
Hannan WJ, Emmett PC, Aitken RJ, Love RG, Millar AM, Muir AL (1982) Effective penetration of the lung periphery using aerosols: concise communication. J Nucl Med 23:872–877
Hayes M, Taplin GV, Chopra SK, Knox DE, Elam D (1979). Improved radioaerosol administration system for routine inhalation lung imaging. Radiology 131:256–258
Line BR (1981) A new perspective and old problems. J Nucl Med 22:827–830
Newman SP, Agnew JE, Pavia D, Clarke SW (1982) Inhaled aerosols: lung deposition and clinical applications. Clin Phys Physiol Meas 3:1–20
Norusis MJ (1986) SPSS/PC + advanced statistics. SPSS Inc, Chicago
Peltier P, Chatal JF, Tellier JL, Pommet R (1985) Perfusion and aerosol lung scintigraphy in patients with suspected pulmonary embolism. European Nuclear Medicine Congress, London
Rahn H, Sadoul P, Farhi LE, Shapiro J (1965) Distribution of ventilation and perfusion in the lobes of the dog’s lung in the suspine and erect position. J Appl Physiol 8:417–426
Ramana L, Alderson PO, Waxman AD, Berman SD, Brachman MB, Kroop SA, Goldsmith M, Tanasescu DE (1986) Regional comparison of Technetium-99m DTPA aerosol and radioactive gasventilation (Xenon and Krypton) studies in patients with suspected pulmonary embolism. J Nucl Med 27; 1391–1396
Secker-Walker RH, Alderson PO, Wilhelm J, Hill RL, Markham J (1975) Regional ventilation-perfusion relationships. Respiration 32:265–276
West JB, Dollery CT (1960) Distribution of blood flow and ventilation-perfusion ratio in the lung, measured with radioactive CO2. J Appl Physiol 15:405–410
Zar JH (1984) Biostatistical analysis. Prentice-Hall International, London
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
van den Brom, W.E., Clercx, C., van Toor, A.J. et al. Quantitative analysis of radioaerosol inhalation and perfusion scintigraphy in dogs. Lung 167, 201–212 (1989). https://doi.org/10.1007/BF02714949
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02714949