Abstract
The influence of the vagus nerve on bronchoconstriction induced by exposure to allergen and acetylcholine (ACH) was tested in two dogs breathing through an endotracheal tube and through a specially designed mask. The prevention of bronchial reaction by bilateral vagus blockade was demonstrated to be similar for animals breathing via mouth and via the tracheal tube.
The effect of vagus blockade, preventing the bronchoconstriction obtained by allergen aerosol and ACH aerosol, and the recovery of the vagus effect after release of the blockade, was studied in a series of four dogs.
Zusammenfassung
In Hundeversuchen wurde der Einfluß des N. vagus auf die Bronchokonstriktion, wie sie durch Allergen-Exposition bzw. Acetylcholin-Inhalation auslösbar ist, bei Mundatmung und bei Atmung durch einen Trachealtubus untersucht.
Partielle bilaterale Vagusblockade blockiert auch die bei Mundatmung auftretende Atemwegsobstruktion in gleicher Weise wie diejenige, die bei Trachealtubusatmung zustande kommt. Nach Freigabe der Vagusblockade waren die entsprechenden bronchokonstriktorischen Reaktionen wieder nachweisbar.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Gold, W.M., Kessler, G.F., Yu, D.Y.C.: Role of vagus nerves in experimental asthma in allergic dogs. J. Appl. Physiol.33, 719 (1972)
Islam, M.S., Ulmer, W.T.: Über die Rolle von Serotonin als Bronchokonstriktor. Pneumonologie148, 135 (1973a)
Islam, M.S., Ulmer, W.T.: Der Wirkungsmechanismus von Serotonin (5 Hydroxytryptamin) und Histamin bei der Atemwegsobstruktion. Respiration30, 360 (1973b)
Lanser, K., Islam, M.S., Ulmer, W.T.: Untersuchungen zur Kontrolle der Ventilationsdurchblutungsregulation der Lunge. Verh. dtsch. Ges. inn. Med.80, 894 (1974)
Nadel, J.A., Widdicombe, J.G.S.: Reflex effects of upper airway irritation on total lung resistance and blood pressure. J. Appl. Physiol.17 861 (1962)
Patterson, R.: personal communication 1974
Ulmer, W.T.: Pathophysiologische Grundlagen obstruktiver Atemwegserkrankungen. Dtsch. med. Wschr.100, 1575 (1975)
Ulmer, W.T., Islam, M.S.: Die Acetylcholinempfindlichkeit des Bronchialbaumes. Respiration31, 137 (1974)
Weiszer, J., Patterson, R., Buzansky, J.J.: Ascaris hypersensitivity in the rhesus monkey. I. A model for the study of immediate type hypersensitivity in the primate. J. Allergy91, 14 (1968)
Widdicombe, J.G., Sterling, G.M.: The automatic nervous system and breathing. Arch. Internal. Med.126, 311 (1970)
Zimmermann, I., Islam, M.S., Lanser, K., Ulmer, W.T.: Antigen induced airway obstruction and the influence of vagus blockade. Respiration33, 95 (1976a)
Zimmermann, I., Islam, M.S., Ulmer, W.T.: Effect of unilateral vagus blockade on antigen-induced airway obstruction. Respiration33, 359 (1976b)
Zimmermann, I., Kowalski, J., Curschmann, P., Ulmer, W.T.: Reaction following allergen inhalation via mouth and via tracheal tube on dogs. Lung154, 41 (1976)
Author information
Authors and Affiliations
Additional information
This research was supported by the Commission of the European Communities for Coal and Steel, Luxemburg
Rights and permissions
About this article
Cite this article
Curschmann, P., Zimmermann, I., Kowalski, J. et al. Role of vagus nerve on upper airways-induced bronchoconstriction. Lung 154, 125–134 (1976). https://doi.org/10.1007/BF02713526
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02713526