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Reaction following allergen inhalation via mouth and via tracheal tube on dogs

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Summary

The diverse effect of AE-aerosol on bronchial system and its sensitising effect against inhalation of ACH, was tested by application of mentioned substances, in a series of 6 dogs, breathing through endotracheal tube and through a special confectioned mask. All the animals presented a marked higher reaction to allergen by aerosol exposition through mask breathing than through endotracheal intubation. No difference was observed between both kinds of breathing, when ACH-aerosol was given.

Zusammenfassung

Die Wirkung von Ascaris-Extrakt-Aerosol auf das Bronchialsystem wurde einmal durch Verabreichung des Aerosols durch einen Trachealtubus und zum anderen durch Verabreichung des Aerosols über eine spezielle Gesichtsmaske an 6 Hunden getestet.

Die bronchokonstriktorische Reaktion war jeweils wesentlich stärker, wenn das Aerosol über die Gesichtsmaske verabreicht wurde. Acetylcholin-Aerosol-Inhalationen zeigten keine derartigen Differenzen.

Die Ergebnisse werden in bezug auf die Lokalisation der Allergenrezeptoren diskutiert.

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Authors and Affiliations

  1. Institut für Lungenfunktionsforschung Bochum in Verbindung mit der Westfälischen Wilhelms-Universität Münster, Germany

    I. Zimmermann, J. Kowalski, P. Curschmann & W. T. Ulmer

Authors
  1. I. Zimmermann
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  2. J. Kowalski
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  3. P. Curschmann
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  4. W. T. Ulmer
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Additional information

This paper was sponsored financially by Europäische Gemeinschaft für Kohle und Stahl, Hohe Behörde, Luxemburg

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Zimmermann, I., Kowalski, J., Curschmann, P. et al. Reaction following allergen inhalation via mouth and via tracheal tube on dogs. Lung 154, 41–49 (1976). https://doi.org/10.1007/BF02713518

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  • DOI: https://doi.org/10.1007/BF02713518

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