Abstract
Estradiol-induced incorporation of radioactive uridine and leucine into the uterus of rat was inhibited by simultaneous treatment with an analogue of gonadotropin releasing hormone. The inhibitory action of gonadotropin releasing hormone was not mediated through modulation of estradiol receptor content. However, estradiol-induced increase in the level of poly(A) polymerase was inhibited by gonadotropin releasing hormone analogue, indicating that the inhibitory effect might involve post-transcriptional phenomenon.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- GnRH:
-
Gonadotropin releasing hormone
- FSH:
-
follicle stimulating hormone
- LH:
-
luteinizing hormone
- hCG:
-
human chorionic gonadotropin
- ODC:
-
ornithine decarboxylase
- GnRHa GnRH:
-
analogue
- TCA:
-
trichloroacetic acid
References
Bambino, T. H., Shreiber, J. R., and Hsueh, A. J. W. (1980)Endocrinology,107, 908.
Bauer, T. W., Moriarty, C. M., and Childs, G. V. (1981)J. Histochem. Cytochem.,29, 1171.
Burton, K. (1956)Biochem. J.,62, 315.
Darnell, J. E., Philipson, L., Wall, R., and Adesnik, M. (1971)Science,174, 507.
Emmens, C. W., Cox, R. I., and Martin, L. (1962)Rec. Prog. Horm. Res.,18, 415.
Eskay, R. L., Mikal, R. S., and Porter, J. C. (1977)Endocrinology,100, 263.
Guillemin, R. (1978)Science,202, 390.
Hruby, D. E. (1978)Biochem, Biophys. Res. Commun.,81, 1425.
Hsueh, A. J. W., and Erickson, G. F. (1979a)Science,204, 854.
Hsueh, A. J. W., and Erickson, G. F. (1979b)Nature (London),281, 66.
Hsueh, A. J. W., and Jones, P. B. C. (1981)Endocrinol. Rev.,2, 437.
Hunter, M. G., Sullivan, M. H. F., Dix, C. J., Aldred, C. F., and Cooke, B. A. (1982)Mol. Cell. Endocrinol.,27, 31.
Jensen, E. V., and Jacobson, H. I. (1962)Recent Prog. Horm. Res.,18, 387.
Lecomte, P., Wang, N. G., Sundaram, K., Rivier, J., Vale, W., and Bardin, C. W. (1982)Endocrinology,110, 1.
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951)J. Biol. Chem.,193, 265.
Madhubala, R., and Reddy, P. R. K. (1982)Biochem. Biophys. Res. Commun.,109, 269.
Magoffin, D. A., Reynolds, D. S., and Erickson, G. F. (1981)Endocrinology,109, 661.
Müller, R. E., and Wotiz, H. H. (1977)Endocrinology,100, 513.
Nillius, S. J., Bergquist, C., and Wide, L. (1978)Contraception,17, 537.
Okulicz, W. C., Boomsma, R. A., Mac Donald, R. G. and Leavitt, W. W. (1983)Biochim. Biophys. Acta,757, 128.
Orava, M. M., Isoma, V. V., and Janne, O. A. (1980)Steroids 36, 689.
Raju, V. S., and Reddy, P. R. K. (1983)Biochem. Biophys. Res. Commun.,115, 451.
Rao, I. M., and Reddy, P. R. K. (1984)Life Sci.,34, 2257.
Rippel, R. H., and Johnson, E. S. (1976)Proc. Soc. Exp. Biol. Med. 152, 432.
Sankaran, M. S., and Prasad, M. R. N. (1972)Gynec. Invest.,3, 142.
Schally, A. V. (1978)Science,202, 18.
Sharpe, R. M. (1982)J. Reprod. Fert.,64, 517.
Sundaram, K., Cao, Y-Q., Wang, N-G., Bardin, C. W., Rivier, J., and Vale, W. (1981)Life Sci.,28, 83.
Traish, A. M., Muller, R. E., and Wotiz, H. H. (1977)J. Biol. Chem.,252, 6823.
Wilson, M. C., Sawicki, S., White, P. A., and Darnell, J. E. (1978)J. Mol. Biol.,126, 23.
Ying, S-Y., and Guillemin, R. (1979)Nature (London) 280, 593.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rao, I.M., Reddy, R.L., Raju, V.S. et al. Inhibitory effect of gonadotropin releasing hormone in the uterus of rat. J Biosci 7, 153–159 (1985). https://doi.org/10.1007/BF02703584
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02703584