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Survival of orally administered isolated intestinalLactobacillus acidophilus in different parts of gastrointestinal tract of mice

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Abstract

A strain ofLactobacillus acidophilus (Strain HF) was isolated from human faeces. A chloramphenicol resistant strain (HFCm) and a strain (HFCmSm) restant to both chloramphenicol and streptomycin were developed from the isolated strain (HF). All the three strains showed similarin vitro susceptibility against host defence factors like gastric acid, bile salts and volatile as well as non-volatile fatty acids.In vivo tests were done by feeding these strains to mice. When the resistant strains were orally administered along with the antibiotic(s) they were stable up to 72 h

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Abbreviations

Cm:

chloramphenicol

Sm:

streptomycin

References

  • Bhattacharya, P. R., Majumdar, M. K. and Ghosh, B. B. (1976)Indian J. Exp. Biol.,14, 508.

    PubMed  CAS  Google Scholar 

  • Bhattacharya, P. R., Majumdar, M. K. and Ghosh, B. B. (1977)Indian J. physiol. Allied Sci.,31, 11.4.

    Google Scholar 

  • Binder, H. J., Filburn, B. and Floch, M. (1975)Am. J. Clin. Nutr.,28, 119.

    PubMed  CAS  Google Scholar 

  • Briggs, M. (1953)J. Gen. Microbiol.,9, 234.

    PubMed  CAS  Google Scholar 

  • Clarke, R. T. J. and Bauchop, T. (1977)Microbial ecology of the gut. (New York: Academic Press) p. 277.

    Google Scholar 

  • Cooper, G. N. (1959)Aust. J. Exp. Biol. Med. Sci.,37, 193.

    Article  PubMed  CAS  Google Scholar 

  • deMan, J. C, Rogosa, M. and Sharpe, M. E. (1960)J. Appl. Bacteriol.,23, 130.

    Google Scholar 

  • Draser, B. S. and Hill, M. J. (1974)Human intestinal flora, (New York: Academic Press) p. 9.

    Google Scholar 

  • Floch, M. H., Gershengorea, W., Elliot, S. and Spiro, M. H. (1971)Gastroenterol,61, 228.

    CAS  Google Scholar 

  • Floch, M. H., Binder, H. F., Filburn, B. and Gershengoren, W. (1972)Am. J. Clin. Nutr.,25, 1418.

    PubMed  CAS  Google Scholar 

  • Freter, R. (1956)J. Exp. Med.,104, 411.

    Article  PubMed  CAS  Google Scholar 

  • Hawley, H. B., Shepherd, P. A. and Wheater, D. M. (1959)J. Appl. Bacteriol.,22, 360.

    Google Scholar 

  • Hirsh, D. C, Burton, G. C., Blenden, D. C. and Tsutakawa, R. (1974)J. Appl. Bacteriol.,37, 327.

    PubMed  CAS  Google Scholar 

  • Lee, A. and Gammell, E. (1972)Infect. Immun.,5, 1.

    PubMed  Google Scholar 

  • Meynell, G. C. and Subbaiah, T. V. (1963)Br. J. Exp. Pathol.,44, 197.

    PubMed  CAS  Google Scholar 

  • Nath, P., Majumdar, M. K. and Ghosh, B. B. (1975)Indian J. Physiol. Allied Sci.,29, 135.

    Google Scholar 

  • Rogosa, M., Wiseman, R. F., Mitchell, J. A. and Disreally, M. N. (1953)J. Bacteriol.,65, 681.

    PubMed  CAS  Google Scholar 

  • Sandine, W. E., Muralidhara, K. S., Ellikar, P. R. and England, D. C. (1972)J. Milk Food Techno.,35, 691.

    Google Scholar 

  • Savage, D. C. (1977)Ann. Rev. Microbiol.,31, 107.

    Article  CAS  Google Scholar 

  • Shahani, K. M. and Ayebo, A. D. (1980)Am. J. Clin. Nutr.,33, 2448.

    PubMed  CAS  Google Scholar 

  • Skerman, B. V. D. (1967)A guide to the identification of genera of Bacteria, (Baltimore: Williams and Wilkins) p. 247.

    Google Scholar 

  • Speck, M. L. (1976)J. Dairy Sci.,59, 338.

    Article  PubMed  CAS  Google Scholar 

  • United State Pharmacopoeia (1970) (Easton: Mac Publishing Co., Pa) p. 1026.

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Author notes

  1. Pramatha R. Bhattacharya

    Present address: Connecticut Health Centre, University of Connecticut, Farmington, USA

Authors and Affiliations

  1. Central Drugs Laboratory, 3, Kyd Street, 700 016, Calcutta

    Pramatha R. Bhattacharya & M. K. Majumdar

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  1. Pramatha R. Bhattacharya
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  2. M. K. Majumdar
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Bhattacharya, P.R., Majumdar, M.K. Survival of orally administered isolated intestinalLactobacillus acidophilus in different parts of gastrointestinal tract of mice. J Biosci 5, 97–105 (1983). https://doi.org/10.1007/BF02702599

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  • DOI: https://doi.org/10.1007/BF02702599

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