Abstract
The experiments were performed on adult Wistar male rats trained to push with the forepaw on a fixed piston inside a narrow tube. It was found that after localized intracerebral injection of a cholinergic antagonist into the dorso-lateral (but not medial) neostriatum (i.e., the caudato-putamen) the behavioral performance requiring brief innate movements remained unchanged, but the performance requiring a prolonged pushing movement (> 50 msec) became disrupted. Microinjection of carbacholine (0.03-3 µ g/1 µ1) did not affect the performance of the acquired movements, whereas scopolamine (3 µ g/1 µ1) led to the significant decrease in pushing time. We conclude that changes in the state of the dorso-lateral neostriatal cholinergic system result only in disturbances of the sensory-controlled component of a complex instrumental movement.
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Dubrovskaya, N.M., Zhuravin, I.A. Role of the striatal cholinergic system in the regulation of learned manipulation in rats. Integrative Physiological and Behavioral Science 30, 127–137 (1995). https://doi.org/10.1007/BF02691681
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DOI: https://doi.org/10.1007/BF02691681