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Effect of fensuccinal on experimental insulin resistance

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of new antioxidant fensuccinal on dexamethasone-induced insulin resistance in rats were studied. Oral administration of fensuccinal in a dose of 25 mg/kg for 2 weeks prevented basal hyperinsulinemia and insulin insensitivity of peripheral tissues. Fensuccinal also attenuated oxidative stress by decreasing the concentrations of primary and secondary lipid peroxidation products in liver homogenates. The ability of fensuccinal to prevent dexamethasone-induced insulin resistance is probably due to its antioxidant properties.

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References

  1. V. A. Vladimirov and A. I. Archakov,Lipid Peroxidation in Biological Membranes [in Russian], Moscow (1972), pp. 239–319.

  2. Z. Platser, M. Vidlakova, and L. Kupila,Chekhosl. Med. Obzor,10, No. 1, 30–41 (1970).

    Google Scholar 

  3. A. Aktinmokun, P. Selby, K. Ramaiya,et al., Diabet. Med., No. 9, 432–437 (1992).

    Article  Google Scholar 

  4. R. Coupland, J. Davidson, and A. Lazarow,Anat. Res.,124, 394 (1956).

    Google Scholar 

  5. R. A. de Fronzo and E. Ferrannini,Diabetes Care,14, 173–195 (1991).

    Article  Google Scholar 

  6. N. Gorbenko, V. Poltorack, and A. Gladkikh,Diabetologia,42, Suppl. 1, A233 (1999).

    Google Scholar 

  7. N. Gorbenko, V. Poltorack, L. Pivovarevich,et al., Horm. Metab. Res., Suppl. 1, 47 (1995).

    Google Scholar 

  8. O. Lowry, N. Rosebrough, A. Farr, and R. Randall,J. Biol. Chem.,193, No. 1, 265–275 (1951).

    PubMed  CAS  Google Scholar 

  9. D. Moller and J. Fliers,N. Engl. J. Med.,325, 938–948 (1992).

    Google Scholar 

  10. H. Mulder, B. Ahren, M. Stridsberg, and F. Sundler,Diabetologia, No. 4, 395–402 (1995).

    Article  Google Scholar 

  11. M. Novelli, M. Barbera, V. Fierabracci,et al., ——Ibid., Suppl. 1, A124 (1996).

    Google Scholar 

  12. G. Paolisso and D. Giugliano, ——Ibid., No. 3, 357 (1996).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Pathophysiology, Ukrainian Institute of Pharmacotherapy of Infectious Diseases, Kharkov

    N. I. Gorbenko, V. V. Poltorak, A. I. Gladkikh & O. V. Ivanova

Authors
  1. N. I. Gorbenko
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  2. V. V. Poltorak
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  3. A. I. Gladkikh
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  4. O. V. Ivanova
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Corresponding author

Correspondence to N. I. Gorbenko.

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 42–44, July, 2000

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Gorbenko, N.I., Poltorak, V.V., Gladkikh, A.I. et al. Effect of fensuccinal on experimental insulin resistance. Bull Exp Biol Med 130, 647–648 (2000). https://doi.org/10.1007/BF02682095

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  • DOI: https://doi.org/10.1007/BF02682095

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